Glycogen synthase kinase-3 beta
(Redirected from
GSK3B
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| Location (UCSC) | Chr 3: 119.82 – 120.09 Mb | Chr 16: 37.91 – 38.07 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Glycogen synthase kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the GSK3B gene.[5][6] In mice, the enzyme is encoded by the Gsk3b gene.[7] Abnormal regulation and expression of GSK-3 beta is associated with an increased susceptibility towards bipolar disorder.[8]
Function
Glycogen synthase kinase-3 (GSK-3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and an inactivating agent of glycogen synthase. Two isoforms, alpha (GSK3A) and beta, show a high degree of amino acid homology.[5] GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation.[9][10] It might be a new therapeutic target for ischemic stroke.
Disease relevance
Homozygous disruption of the Gsk3b locus in mice results in embryonic lethality during mid-gestation.[7] This lethality phenotype could be rescued by inhibition of tumor necrosis factor.[7]
Two SNPs at this gene, rs334558 (-50T/C) and rs3755557 (-1727A/T), are associated with efficacy of lithium treatment in bipolar disorder.[11]
Signaling pathways
Pharmacological inhibition of ERK1/2 restores GSK-3 beta activity and protein synthesis levels in a model of tuberous sclerosis.[12]
Interactions
GSK3B has been shown to
interact
with:
- KIAA1211L[13]
See also
- Glycogen synthase kinase 3
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000082701 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022812 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ PMID 7980435.
- PMID 10486203.
- ^ S2CID 205007364.
- S2CID 43214075.
- PMID 1333807.
- ^ "Entrez Gene: GSK3B glycogen synthase kinase 3 beta".
- PMID 24992082.
- PMID 28646232.
- ^ EMBL-EBI. "EMBL European Bioinformatics Institute". www.ebi.ac.uk. Retrieved 2017-04-26.
{{cite web}}: Check|url=value (help) - ^ PMID 12147701.
- ^ PMID 12511557.
- S2CID 10875463.
- S2CID 40432152.
- PMID 12183362.
- PMID 15178691.
- PMID 11251183.
- PMID 10330181.
- PMID 9731200.
- PMID 21295697.
- PMID 9819408.
- PMID 11152665.
- PMID 18172167.
- S2CID 15884556.
- PMID 12794074.
- PMID 12048243.
- PMID 12054501.
- S2CID 16047397.
Further reading
- Turenne GA, Price BD (2001). "Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity". BMC Cell Biology. 2: 12. PMID 11483158.
- Plyte SE, Hughes K, Nikolakaki E, Pulverer BJ, Woodgett JR (December 1992). "Glycogen synthase kinase-3: functions in oncogenesis and development". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1114 (2–3): 147–62. PMID 1333807.
- Morishima-Kawashima M, Hasegawa M, Takio K, Suzuki M, Yoshida H, Watanabe A, et al. (1995). "Hyperphosphorylation of tau in PHF". Neurobiology of Aging. 16 (3): 365–71, discussion 371–80. S2CID 22471158.
- Jope RS, Bijur GN (2002). "Mood stabilizers, glycogen synthase kinase-3beta and cell survival". Molecular Psychiatry. 7 (Suppl 1): S35-45. PMID 11986994.
- Bhat RV, Budd SL (2003). "GSK3beta signalling: casting a wide net in Alzheimer's disease". Neuro-Signals. 11 (5): 251–61. S2CID 13650262.
- Wang W, Li M, Wang Y, Li Q, Deng G, Wan J, et al. (December 2016). "GSK-3β inhibitor TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats". Molecular Neurobiology. 53 (10): 7028–7036. PMID 26671619.
- Nadri C, Kozlovsky N, Agam G (September 2003). "[Schizophrenia, neurodevelopment and glycogen synthase kinase-3]". Harefuah. 142 (8–9): 636–42, 644. PMID 14518171.
- Mulholland DJ, Dedhar S, Wu H, Nelson CC (January 2006). "PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer". Oncogene. 25 (3): 329–37. PMID 16421604.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Glycogen synthase kinase-3 beta (GSK3B)
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