Galactose-alpha-1,3-galactose

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Galactose-alpha-1,3-galactose
Names
Systematic IUPAC name
3-O-α-D-Galactopyranosyl-D-galactopyranose
Other names
Alpha-gal; 3-α-Galactobiose; Gal(α1-3)Gal; alpha-D-Gal-(1→3)-D-Gal
Identifiers
3D model (
JSmol
)
ChemSpider
UNII
  • InChI=1S/C12H22O11/c13-1-3-5(15)7(17)8(18)12(22-3)23-10-6(16)4(2-14)21-11(20)9(10)19/h3-20H,1-2H2/t3-,4-,5+,6+,7+,8-,9-,10+,11?,12-/m1/s1
    Key: QIGJYVCQYDKYDW-SDOYDPJRSA-N
  • O([C@@H]1[C@@H](O)C(O)O[C@H](CO)[C@@H]1O)[C@H]2O[C@@H]([C@H](O)[C@H](O)[C@H]2O)CO
Properties
C12H22O11
Molar mass 342.297 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Galactose-α-1,3-galactose, commonly known as alpha gal and the Galili antigen, is a

catarrhines,[1] including humans, who have lost the GGTA1 gene. Their immune systems recognize it as a foreign body and produce xenoreactive immunoglobulin M (IgM) antibodies, leading to organ rejection after transplantation.[2]

Anti-alpha gal

castor bean tick (Ixodes ricinus) in Sweden.[8]

A bacterial

vaccine adjuvant and for enhancing wound healing.[10][11]

See also

References

  1. ^ Singh, S., Thompson, J. A., Yilmaz, B., Li, H., Weis, S., Sobral, D., Truglio, M., Aires da Silva, F., Aguiar, S., Carlos, A. R., Rebelo, S., Cardoso, S., Gjini, E., Nuñez, G., & Soares, M. P. (2021). Loss of α-gal during primate evolution enhanced antibody-effector function and resistance to bacterial sepsis. Cell Host & Microbe, 29 (3). https://doi.org/10.1016/j.chom.2020.12.017
  2. PMID 10910270
    .
  3. PMID 18047841
    .
  4. ^ Williams L (December 27, 2013). "Just one bite". Sydney Morning Herald. Australia. p. 20.
  5. ISSN 1081-1206
    .
  6. PMID 31156631
    .
  7. ^ "Bad bite: Doctors see surge of sudden meat allergies caused by ticks that are spreading in US" USNews, July 7, 2014
  8. S2CID 43353109
    .
  9. PMID 18227066
    .
  10. PMID 23578170
    .
  11. S2CID 34171020
    .

External links
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