Gemazocine

Gemazocine

Clinical data
ATC code	None
Identifiers
IUPAC name 10-(cyclopropylmethyl)-1-ethyl-13,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2,4,6-trien-4-ol
JSmol)	Interactive image
SMILES Oc1ccc4c(c1)C2(C(C(N(CC2)CC3CC3)C4)(C)C)CC
InChI InChI=1S/C20H29NO/c1-4-20-9-10-21(13-14-5-6-14)18(19(20,2)3)11-15-7-8-16(22)12-17(15)20/h7-8,12,14,18,22H,4-6,9-11,13H2,1-3H3 Key:AFZOCGNTFCGOEE-UHFFFAOYSA-N

Gemazocine (R-15,497), also known as cyclogemine, is a non-selective opioid antagonist of the benzomorphan class.^[1][2][3] It may have partial agonist properties at some of the opioid receptors, such as at the kappa receptor (as it induces dysphoric effects in humans), but seems to be generally antagonistic in its actions.^[4]

References