Generalized granuloma annulare
| Generalized granuloma annulare | |
|---|---|
 | |
| Specialty | Dermatology  |
Generalized granuloma annulare is a skin condition of unknown cause, tending to affect women in the fifth and sixth decades, presenting as a diffuse but symmetrical,
Signs and symptoms
Generalized granuloma annulare is a chronic granulomatous dermatosis that typically affects young adults' distal extremities and manifests as annular grouped papules.[2] On the trunk and extremities, numerous flesh-colored papules arranged in an annular pattern are the hallmark of generalized granuloma annulare. These lesions are frequently itchy, in contrast to the traditional presentation.[3]
Causes
A variety of factors, such as infection, sun exposure, medication use, and trauma, appear to play a role in the development of the disease.[4]
Diagnosis
It has been observed that certain laboratory abnormalities exist, such as hyperlipidemia, hypergammaglobulinemia, and the presence of circulating antinuclear antibodies.[5] Histopathologic analysis may show lymphohistiocytic granuloma-related alterations primarily in the papillary and mid dermis. Palisaded or interstitial patterns, or a combination of the two, may be seen in inflammatory infiltrates.[4]
Treatment
Generalized granuloma annulare is mostly treated with
Epidemiology
Generalized granuloma annulare accounts for up to 15% of granuloma annulare cases.[3]
See also
- Granuloma annulare
- List of cutaneous conditions
- List of human leukocyte antigen alleles associated with cutaneous conditions
References
Further reading
- Saber, Mina; Khalili Tembi, Roghaye Sadat; Asilian, Ali (2021). "Generalized granuloma annulare in a case of breast cancer: A case report and review of the literature". Clinical Case Reports. 9 (10): e04980. PMID 34703610.
- Polineni, Sai P.; Lawyer, Steven (2020). "Generalized granuloma annulare associated with essential thrombocythemia". Clinical Case Reports. 8 (6): 1065–1068. PMID 32577266.