Genetic admixture
 | This article may be too technical for most readers to understand. (January 2023) |
Genetic admixture occurs when previously isolated populations interbreed resulting in a population that is descended from multiple sources. It can occur between species, such as with hybrids, or within species, such as when geographically distant individuals migrate to new regions. It results in gene pool that is a mix of the source populations.[1][2][3]
Examples
Climatic cycles facilitate genetic admixture in cold periods and genetic diversification in warm periods.[4] Natural flooding can cause genetic admixture within populations of migrating fish species.[5] Genetic admixture may have an important role for the success of populations that colonise a new area and
Mapping
Admixture mapping is a method of
Admixture mapping is based on the assumption that differences in disease rates or phenotypes are due in part to differences in the frequencies of disease-causing or phenotype-causing genetic variants between populations. In an admixed population, these causal variants occur more frequently on chromosomal segments inherited from one or another ancestral population. The first admixture scans were published in 2005 and since then genetic contributors to a variety of disease and trait differences have been mapped.[8] By 2010, high-density mapping panels had been constructed for African Americans, Latino/Hispanics, and Uyghurs.
See also
- Chloroplast capture
- Gene cluster
- Gene flow
- Haplogroup
- Human genetic variation
- Hybrid
- Hybrid vigor
- Interbreeding between archaic and modern humans
- Introgression
- Population groups in biomedicine
References
Further reading
- Balding (2007). "Glossary of Genetic Terms". Handbook of statistical genetics, Volume 1. John Wiley & Sons. ISBN 978-0-470-05830-5.
- Foulkes (28 April 2009). "Glossary of Terms". Applied Statistical Genetics With R: For Population-based Association Studies. Springer. p. 250. ISBN 978-0-387-89553-6.
- Stone; et al. (2007). "Glossary of Terms". Genes, culture, and human evolution: a synthesis. Wiley. ISBN 978-1-4051-5089-7.
- Kolbe JJ, Glor RE, Schettino LR, Lara AC, Losos AL, Losos JB (2004) Genetic Variation Increases during Biological Invasion by a Cuban Lizard. Nature 431: 171-181
- Lenormand T (2002). Gene flow and the limits to natural selection. Trends in Ecology and Evolution. 17:183-189
- Shriner 2013, "Overview of Admixture Mapping"