Genetic history of the Indigenous peoples of the Americas

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The genetic history of the Indigenous peoples of the Americas is divided into two distinct periods: the initial peopling of the Americas during about 20,000 to 14,000 years ago (20–14 kya), and European contact, after about 500 years ago.[1][2] The first period of the genetic history of Indigenous Americans is the determinant factor for the number of genetic lineages, zygosity mutations, and founding haplotypes present in today's Indigenous American populations.[3]

Indigenous American populations descend from an

Ancient East Asian lineage which diverged from other East Asian peoples prior to the Last Glacial Maximum, between 36,000 and 25,000 years ago, and subsequently migrated into Siberia, where they merged with Ancient North Eurasians, a Paleolithic Siberian population with deep affinities to both European and Eastern Asian populations. They later dispersed throughout the Americas after about 16,000 years ago (exceptions being the Na-Dene and Eskimo–Aleut speaking groups, which are derived partially from Siberian populations which entered the Americas at a later time).[4][5]

Analyses of genetics among Indigenous American and Siberian populations have been used to argue for early isolation of

Linguists and biologists have reached a similar conclusion based on analysis of Indigenous American language groups and ABO blood group system distributions.[14][15][16][17]

Autosomal DNA

Main article: Autosome
See also: Human genetic variation
Principal component analysis showing the Native American cluster in other Eurasian populations.[18]
Position of Native Americans on a Principal component analysis of global human population clusters from the 1000 Genomes project.

Genetic diversity and population structure in the American landmass is also measured using

Mesoamerican and Andean populations, a scenario that implies that coastal routes (in this case along the coast of the Pacific Ocean) were easier for migrating peoples (more genetic contributors) to traverse in comparison with inland routes.[19]

The overall pattern suggests that the Americas were colonized by a small number of individuals (effective size of about 70), which grew by many orders of magnitude over 800 – 1000 years.[21][22] The data also shows that there have been genetic exchanges between Asia, the Arctic, and Greenland since the initial peopling of the Americas.[22][23]

According to an autosomal genetic study from 2012,

Na-Dene inherited a tenth of their ancestry from a third migrant wave. The initial settling of the Americas was followed by a rapid expansion southwards along the west coast, with little gene flow later, especially in South America. One exception to this are the Chibcha speakers of Colombia, whose ancestry comes from both North and South America.[24]

In 2014, the autosomal DNA of a 12,500+ year old infant from Montana was sequenced.[25] The DNA was taken from a skeleton referred to as Anzick-1, found in close association with several Clovis artifacts. Comparisons showed strong affinities with DNA from Siberian sites, and virtually ruled out that particular individual had any close affinity with European sources (the "Solutrean hypothesis"). The DNA also showed strong affinities with all existing Indigenous American populations, which indicated that all of them derive from an ancient population that lived in or near Siberia.[26]

Linguistic studies have reinforced genetic studies, with relationships between languages found among those spoken in Siberia and those spoken in the Americas.[27]

Two 2015 autosomal DNA genetic studies confirmed the Siberian origins of the Indigenous peoples of the Americas. However, an ancient signal of shared ancestry with Australasians (Indigenous peoples of Australia, Melanesia, and the

Amazon region. This signal, also doubt as 'population Y' has been more recently linked to a deep East Asian population, which can be associated with the Tianyuan man, and which is ancestral to modern East Asians. The deep Tianyuan and East Asian lineages form a sister branch to Andamanese and Australasian populations, with all of them being branches of Ancient East Eurasians. The main migration coming out of Siberia into the Americas would have happened 23,000 years ago.[28][29][30][31][32][33][34]

A 2018 study analysed ancient Indigenous samples. The genetic evidence suggests that all Indigenous Americans ultimately descended from a founding population that combined

Paleosiberians, was found to have been largely East Eurasian genetically, and showed high affinity with contemporary East Asians, as well as Jōmon period samples of Japan, confirming that Ancestral Indigenous Americans split from an East-Eurasian source population somewhere in eastern Siberia.[35]

A study published in the Nature journal in 2018 concluded that Indigenous Americans descended from a single founding population which initially divided from East Asians about ~36,000 (±1,500) years BP, with gene flow between this divided group of Ancestral Indigenous Americans and Siberians persisting until about ~25,000 (±1,100) years BP, before becoming isolated in the Americas or Beringia at ~22,000 years BP. Northern and Southern American Indigenous sub-populations split from each other at roughly ~17,500 to 14,600 years BP. There is also some evidence for a back-migration from the Americas into Siberia after ~11,500 years BP.[4]

A study published in the Cell journal in 2019, analysed 49 ancient Indigenous American samples from all over North and South America, and concluded that all Indigenous American populations descended from a single ancestral source population which divided from Siberians and East Asians, and gave rise to the Ancestral Indigenous Americans, which later diverged into the various Indigenous groups. The authors further dismissed previous claims for the possibility of two distinct population groups among the peopling of the Americas. Both, Northern and Southern Indigenous Americans are closest to each other, and do not show evidence of admixture with hypothetical previous populations.[36]

A qpGraph on the formation of Ancient Paleo-Siberians and Native American populations.[37]

A review article published in the Nature journal in 2021, which summarized the results of previous genomic studies, similarly concluded that all Indigenous Americans descended from the movement of people from Northeast Asia into the Americas. These Ancestral Americans, once south of the continental ice sheets, spread and expanded rapidly, and branched into multiple groups, which later gave rise to the major subgroups of Indigenous American populations. The study also dismissed the existence, inferred from craniometric data, of a hypothetical distinct non-Indigenous American population (suggested to have been related to Indigenous Australians and Papuans), sometimes called "Paleoamerican".[38][39]

Overall, the 'Ancestral Native Americans' descended from an '

Ancient North Eurasians. This 'Ancient Paleo-Siberian' population gave rise to both Indigenous peoples of Siberia and Native Americans.[40] Around 67% of the ancestry of Native Americans is derived from East Asian sources, while c. 33% is derived from an Ancient North Eurasian (ANE) source.[36]

Y-chromosome DNA

Main articles: Y chromosome and Human Y-chromosome DNA haplogroup
Map of Y-Chromosome Haplogroups - Dominant haplogroups in pre-colonial populations with proposed migration routes.

A "Central Siberian" origin has been postulated for the paternal lineage of the source populations of the original migration into the Americas.[41]

Membership in haplogroups

C3b implies Indigenous American patrilineal descent.[42]

The

autosomal DNA (atDNA) mutations.[9][43][44] This suggests that the earliest migrants into the northern extremes of North America and Greenland derived from later migrant populations.[45][46]

Haplogroup Q

Main article: Haplogroup Q-M242
Frequency distribution of haplogroup Q-M242.[47]

Haplogroup Q (Y-DNA) (phylogenetic name).[48][49] In Eurasia, haplogroup Q is found among Indigenous Siberian populations, such as the modern Chukchi and Koryak peoples, as well as some Southeast Asians, such as the Dayak people. In particular, two groups exhibit large concentrations of the Q-M242 mutation, the Ket (93.8%) and the Selkup (66.4%) peoples.[50] The Ket are thought to be the only survivors of ancient wanderers living in Siberia.[51] Their population size is very small; there are fewer than 1,500 Ket in Russia.2002[21] The Selkup have a slightly larger population size than the Ket, with approximately 4,250 individuals.[52]

Starting the

Q-M3 (SNP) mutation.[53] These descendants migrated all over the Americas.[48]

western Alaskan interior. The Beringia land mass began submerging, cutting off land routes.[50][57][19]

Since the discovery of Q-M3, several

Q-NWT01
.

Haplogroup R1

Main article: Haplogroup R1

Y-DNA haplogroup Q.[59]

Initially, there was debate about the origin of haplogroup R1b in Native Americans. Two early studies suggested that this haplogroup could have been one of the founding Siberian lineages of Native Americans, however this is now considered unlikely, because the R1b lineages commonly found in Native Americans are in most cases identical to those in western Europeans, and its highest concentration is found among a variety of the Algonquin speaking tribes in eastern North America.[60]

Thus, according to several authors, R1b was most likely introduced through admixture during the post-1492 European settlement of North America.[61][62][63]

R1 (M173) is found predominantly in North American groups like the

Tohono O'odham (Papago) (38%). Its highest frequency is found in northeastern North America, and declines in frequency from east to west. In southwestern Native American tribes the frequency of this haplogroup is as low as 4%.[59][64]

Haplogroup C-P39

Main article: Haplogroup C-M217
Distribution of haplogroup C2=C-M217 (YDNA), formerly C3.[65]

Haplogroup C-M217 is found mainly in Indigenous Siberians,

(Y-DNA) haplogroup C-M130. Haplogroup C-M217 descendant C-P39 is most commonly found in today's Na-Dene speakers, with the greatest frequency found among the Athabaskans at 42%, and at lesser frequencies in some other Indigenous American groups.[10] This distinct and isolated branch C-P39 includes almost all the Haplogroup C-M217 Y-chromosomes found among all Indigenous peoples of the Americas.[66]

Some researchers feel that this may indicate that the Na-Dene migration occurred from the

Inupiat and Yupik expansions.[10][9][67]

In addition to in Na-Dene peoples, haplogroup C-P39 (C2b1a1a) is also found among other Indigenous Americans such as

Wayuu people of Colombia and Venezuela.[68][69]

Data

Listed here are notable Indigenous peoples of the Americas by

ethnic and linguistic designations in the first two columns, the fourth column (n) is the sample size studied, and the other columns give the percentage of the particular haplogroup
.

Group Language Place n
C
Q
 R1 Others Reference
Algonquian[nb 1] Algic Northeast North America 155 7.7 33.5 [nb 2] 38.1 20.6 Bolnick 2006[70]
Apache Na-Dene SW United States 96 14.6 78.1 5.2 2.1 Zegura 2004[10]
Athabaskan[nb 3]
 Na-Dene Western North America 243 11.5 70.4 18.1 Malhi 2008[59]
Cherokee Iroquoian SE United States 62 1.6 50.0 [nb 4] 37.1 11.3 Bolnick 2006[70]
Cherokee Iroquoian Eastern North America 30 50.0 46.7 3.3 Malhi 2008[59]
Cheyenne
 Algic United States 44 16 61 16 7 Zegura 2004[10]
Chibchan[nb 5]
 Macro-Chibchan Panama 26 100 Zegura 2004[10]
Chipewyan
 Na-Dene Canada 48 6 31 [nb 6] 62.5[nb 7] Bortoloni 2003[8]
Chippewa
 Algic Eastern North America 97 4.1 15.9 [nb 8] 50.5 29.9 Bolnick 2006[70]
Dogrib
 Na-Dene Canada 15 33 27 40 Malhi 2008[59]
Dogrib
 Na-Dene Canada 37 35.1 45.9 [nb 9] 8.1 10.8 Dulik 2012[71]

Gê[nb 10]

 Macro-Jê Brazil 51 92 [nb 11] 8 Bortoloni 2003[8]
Guaraní Tupian Paraguay 59 86 [nb 12] 9 5 Bortoloni 2003[8]
Inga
Quechua
 Colombia 11 78 [nb 13] 11 11 Bortoloni 2003[8]
Inuit
Eskimo–Aleut
 North American Arctic 60 80.0 11.7 8.3 Zegura 2004[10]
Inuvialuit
Eskimo–Aleut
 Canada 56 1.8 55.1 [nb 14] 33.9 8.9 Dulik 2012[71]

Maya

Mayan Mesoamerica 71   87.3   12.7 Zegura 2004[10]
Mixe Mixe–Zoque Mexico 12 100 Zegura 2004[10]
Mixtec
 Oto-Manguean Mexico 28 93 7 Zegura 2004[10]
Muskogean[nb 15]
 Muskogean SE United States 36   2.8   75 [nb 16] 11.1 11.1 Bolnick 2006[70]
Nahua
 Uto-Aztecan Mexico 17 94 6 Malhi 2008[59]
Native Americans
(United States) 		United States 398 9.0 58.1 22.2 10.7 Hammer 2005[72]
Navajo
 Na-Dene SW United States 78 1.3 92.3 2.6 3.8 Zegura 2004[10]
Indigenous North Americans
 North America 530 6.0 77.2 12.5 4.3 Zegura 2004[10]
Papago
 Uto-Aztecan SW United States 13 61.5 38.5 Malhi 2008[59]
Seminole Muskogean Eastern North America 20 45.0 50.0 5.0 Malhi 2008[59]
Sioux Macro-Siouan Central North America 44 11 25 50 14 Zegura 2004[10]
South America Amerindian South America 390 92 [nb 17] 4 4 Bortoloni 2003[8]
Tanana
 Na-Dene Northwest North America 12 42 42 8 8 Zegura 2004[10]
Ticuna
 Ticuna–Yuri West Amazon basin 33 100 [nb 18] Bortoloni 2003[8]
Tlingit
 Na-Dene Pacific Northwest 11 18 [nb 19] 82 [nb 20] Dulik 2012[71]
Tupí–Guaraní[nb 21]
 Tupian Brazil 54 100 [nb 22] Bortoloni 2003[8]
Uto-Aztecan[nb 23]
 Uto-Aztecan Mexico, Arizona 167 93.4 6.0 Malhi 2008[59]
Warao Warao (isolate) Caribbean South America 12 100 [nb 24] Bortoloni 2003[8]
Wayúu Arawakan Guajira Peninsula 19 69 [nb 25] 21 10 Bortoloni 2003[8]
Wayúu Arawakan Guajira Peninsula 25 8 36 44 12 Zegura 2004[10]
Yagua
 Peba–Yaguan Peru 7 100 [nb 26] Bortoloni 2003[8]
Yukpa Cariban Colombia 12 100 [nb 27] Bortoloni 2003[8]
Zapotec Oto-Manguean Mexico 16 75 6 19 Zegura 2004[10]
Zenú extinct Colombia 30 81 [nb 28] 19 Bortoloni 2003[8]

Mitochondrial DNA

Main articles: Mitochondrial DNA, Human mitochondrial genetics, and Human mitochondrial DNA haplogroup

The common occurrence of the mtDNA Haplogroups A, B, C, and D among eastern Asian and Indigenous American populations has long been recognized, along with the presence of Haplogroup X.

Baikal region of southern Siberia.[74] Some subclades of C and D closer to the Indigenous American subclades occur among Mongolian, Amur, Japanese, Korean, and Ainu populations.[73][75] A 2023 DNA study found that "[i]n addition to previously described ancestral sources in Siberia, Australo-Melanesia, and Southeast Asia, ... northern coastal China also contributed to the gene pool of Native Americans" as well as that of Japanese people.[76]

Distribution of haplogroup X

When studying human mitochondrial DNA haplogroup, the results indicated that Indigenous American haplogroups, including haplogroup X, are part of a single founding East Asian population. It also indicates that the distribution of mtDNA haplogroups and the levels of sequence divergence among linguistically similar groups were the result of multiple preceding migrations from Bering Straits populations.[77] All Indigenous American mtDNA can be traced back to five haplogroups: A, B, C, D and X.[78][79] More specifically, Indigenous American mtDNA belongs to sub-haplogroups A2, B2, C1b, C1c, C1d, D1, and X2a (with minor groups C4c, D2a, and D4h3a).[6][77] This suggests that 95% of Indigenous American mtDNA is descended from a minimal genetic founding female population, comprising sub-haplogroups A2, B2, C1b, C1c, C1d, and D1.[78] The remaining 5% is composed of the X2a, D2a, C4c, and D4h3a sub-haplogroups.[77][78]

X is one of the five mtDNA haplogroups found in Indigenous Americans. Native Americans mostly belong to the X2a clade, which has never been found in the Old World.[80] According to Jennifer Raff, X2a probably originated in the same Siberian population as the other four founding maternal lineages.[81]

Haplogroup X genetic sequences diverged about 20,000 to 30,000 years ago to give two sub-groups, X1 and X2. X2's subclade X2a occurs only at a frequency of about 3% for the total current Indigenous population of the Americas.

Tarahumara 1.8% (1/53) and Huichol 20% (3/15)[88]

Sequencing of the mitochondrial genome from

Aleut and Siberian Yupik populations.[89] This suggests that the colonizers of the far north, and subsequently Greenland, originated from later coastal populations.[89] Then began a genetic exchange in the northern extremes introduced by the Thule people (proto-Inuit) approximately 800–1,000 years ago.[44][90] These final Pre-Columbian migrants introduced haplogroups A2a and A2b to the existing Paleo-Eskimo populations of Canada and Greenland, culminating in the modern Inuit.[44][90]

Codes for populations are as follow: North America: 1 = Chukchy, 2 = Eskimos; 3 = Inuit (collected from the HvrBase database; 4 = Aleuts; 5 = Athapaskan; 6 = Haida; 7 = Apache, 8 = Bella Coola; 9 = Navajo; 10 = Sioux, 11 = Chippewa, 12 = Nuu-Chah-Nult; 13 = Cheyenne; 14 = Muskogean populations; 15 = Cheyenne-Arapaho; 16 = Yakima; 17 = Stillwell Cherokee; Meso-America: 18 = Pima; 19 = Mexico; 20 = Quiche; 21 = Cuba; 22 = El Salvador; 23 = Huetar; 24 = Emberá; 25 = Kuna; 26 = Ngöbé; 27 = Wounan; South America: 28 = Guahibo; 29 = Yanomamo from Venezuela; 30 = Gaviao; 31 = Yanomamo from Venezuela and Brazil; 32 = Colombia; 33 = Ecuador (general population), 34 = Cayapa; 35 = Xavante; 36 = North Brazil; 37 = Brazil; 38 = Curiau; 39 = Zoró; 40 = Ignaciano, 41 = Yuracare; 42 = Ayoreo; 43 = Araucarians; 44 = Pehuenche, 45 = Mapuche from Chile; 46 = Coyas; 47 = Tacuarembó; 48 = Uruguay; 49 = Mapuches from Argentina; 50 = Yaghan
Frequency distribution of the main mtDNA American haplogroups in Indigenous American populations.

A route through Beringia is seen as more likely than the Solutrean hypothesis.[91] An abstract in a 2012 issue of the "American Journal of Physical Anthropology" states that "The similarities in ages and geographical distributions for C4c and the previously analyzed X2a lineage provide support to the scenario of a dual origin for Paleo-Indigenous Americans. Taking into account that C4c is deeply rooted in the Asian portion of the mtDNA phylogeny and is indubitably of Asian origin, the finding that C4c and X2a are characterized by parallel genetic histories definitively dismisses the controversial hypothesis of an Atlantic glacial entry route into North America."[92]

Another study, also focused on the mtDNA (which is inherited through only the maternal line),[6] revealed that the Indigenous people of the Americas can trace their maternal ancestry back to a few founding lineages from East Asia, which would have arrived by way of the Bering Strait. According to this study, it is probable that the ancestors of the Indigenous Americans would have remained for a time in the region of the Bering Strait, after which there would have been a rapid movement of settling of the Americas, taking the founding lineages to South America.

According to a 2016 study, focused on mtDNA lineages, "a small population entered the Americas via a coastal route around 16.0 ka, following previous isolation in eastern Beringia for ~2.4 to 9 thousand years after separation from eastern Siberian populations. Following a rapid movement throughout the Americas, limited gene flow in South America resulted in a marked phylogeographic structure of populations, which persisted through time. All of the ancient mitochondrial lineages detected in this study were absent from modern data sets, suggesting a high extinction rate. To investigate this further, we applied a novel principal components multiple logistic regression test to Bayesian serial coalescent simulations. The analysis supported a scenario in which European colonization caused a substantial loss of pre-Columbian lineages".[93]

Genetic admixture

Main article: Genetic admixture

Ancient Beringians

Main article: Ancient Beringian
Schematic illustration of maternal gene flow in and out of Beringia.Colours of the arrows correspond to approximate timing of the events and are decoded in the coloured time-bar. The initial peopling of Berinigia (depicted in light yellow) was followed by a standstill after which the ancestors of Indigenous Americans spread swiftly all over the New World, while some of the Beringian maternal lineages–C1a-spread westwards. More recent (shown in green) genetic exchange is manifested by back-migration of A2a into Siberia and the spread of D2a into north-eastern America that post-dated the initial peopling of the New World.
Figure 2. Schematic illustration of maternal (mtDNA) gene-flow in and out of Beringia (long chronology, single source model).

Recent archaeological findings in Alaska have shed light on the existence of a previously unknown Indigenous American population that has been academically named "Ancient Beringians".[94] Although it is popularly agreed among archeologists that early settlers had crossed into Alaska from Russia through the Bering Strait land bridge, the issue of whether or not there was one founding group or several waves of migration is a controversial and prevalent debate among academics in the field today. In 2018, the sequenced DNA of an Indigenous girl, whose remains were found at the Upward Sun River archaeological site in Alaska in 2013, proved not to match the two recognized branches of Indigenous Americans and instead belonged to the early population of Ancient Beringians.[95] This breakthrough is said to be the first direct genomic evidence that there was potentially only one wave of migration in the Americas that occurred, with genetic branching and division transpiring after the fact. The migration wave is estimated to have emerged about 20,000 years ago.[94] The Ancient Beringians are said to be a common ancestral group among contemporary Indigenous American populations today, which differs in results collected from previous research that suggests that modern populations are descendants of either Northern and Southern branches.[94] Experts were also able to use wider genetic evidence to establish that the split between the Northern and Southern American branches from the Ancient Beringians in Alaska only occurred about 17,000 and 14,000 years,[24] further challenging the concept of multiple migration waves occurring during the very first stages of settlement.

Genetic evidence for

Sundadont lineages to the remote populations in the South American rain forest, and in the genetics of Patagonians-Fuegians.[96][97]

Nomatto et al. (2009) proposed migration into Beringia occurred between 40,000 and 30,000 BP, with a pre-LGM migration into the Americas followed by isolation of the northern population following closure of the ice-free corridor.[98]

A 2016 genetic study of Indigenous peoples of the Amazonian region of Brazil (by Skoglund and Reich) showed evidence of admixture from a separate lineage of an otherwise unknown ancient people. This ancient group appears to be related to modern day "

Ypykuéra, "which means 'ancestor' in the Tupi language family".[30] A 2021 genetic study dismissed the existence of an hypothetical Australasian component among Indigenous Americans. The signal of the hypothetical Australasian component, can also be reproduced using the Basal-East Asian Tianyuan man sample, and thus does not represent "real Australasian affinity". The authors explained that the previous claims of possibly Australasian ancestry were based on a misinterpreted genetic echo, which was revealed to represent early East-Eurasian gene flow (represented by the 40,000 BC old Tianyuan sample) into Aboriginal Australians and Papuans, which was lost in modern East Asians.[38][39]

Archaeological evidence for pre-LGM human presence in the Americas was first presented in the 1970s.[99][100] notably the "Luzia Woman" skull found in Brazil.[101][102][103]

Old world

See also: Multiracial Americans
The current distribution of Indigenous peoples (based on self-identification, not genetic data).

Substantial

racial admixture has taken place during and since the European colonization of the Americas.[104][105]

South and Central America

In Latin America in particular, significant racial admixture took place between the Indigenous American population, the European-descended colonial population, and the Sub-Saharan African populations

imported as slaves. From about 1700, a Latin American terminology developed to refer to the various combinations of mixed racial descent produced by this.[106]

Many individuals who self-identify as one race exhibit genetic evidence of a

Spanish colonist and Portuguese colonist as "Castas".[110]

North America

Main articles: Native Americans in the United States § Admixture and genetics, Métis, and Cherokee descent

The

Métis" or "Bois-Brûlés" by the French colonists. In some contexts these peoples have also been referred to as "mixed-bloods", or "country-born" by the English and Scottish colonists.[112]

blood quantum.[115]

In the

pretendians are common.[120][121]

Some tribes have adopted

Certificates of Degree of Indian Blood, and practice disenrollment of tribal members unable to prove they are the child of an enrolled tribal member. In these cases, the tribe may demand a paternity test. For some, this has become a contentious issue in Native American reservation politics.[122]

European diseases and genetic modification

A team led by Ripan Malhi, an anthropologist at the

University of Illinois in Urbana, conducted a study where they used a scientific technique known as whole exome sequencing to test immune-related gene variants within Indigenous Americans.[123] Through analyzing ancient and modern Indigenous DNA, it was found that HLA-DQA1, a variant gene that codes for protein in charge of differentiating between healthy cells from invading viruses and bacteria were present in nearly 100% of ancient remains but only 36% in modern Indigenous Americans.[123] These finding suggest that European-borne epidemics such as smallpox
altered the disease landscape of the Americas, leaving survivors of these outbreaks less likely to carry variants like HLA-DQA1. This made them less able to cope with new diseases. The change in genetic makeup is measured by scientists to have occurred around 175 years ago, during a time when the smallpox epidemic was ranging through the Americas.

Blood groups

Main article: ABO blood group system
Frequency of O group in Indigenous populations. Note the predominance of this group in Indigenous Americans.

Prior to the 1952 confirmation of DNA as the hereditary material by

blood proteins to study human genetic variation.[124][125] The ABO blood group system is widely credited to have been discovered by the Austrian Karl Landsteiner, who found three different blood types in 1900.[126] Blood groups are inherited from both parents. The ABO blood type is controlled by a single gene (the ABO gene) with three alleles: i, IA, and IB.[127]

Research by

blood groups A, B and O differed greatly from region to region.[125] The "O" blood type (usually resulting from the absence of both A and B alleles) is very common around the world, with a rate of 63% in all human populations.[128] Type "O" is the primary blood type among the Indigenous populations of the Americas, particularly within Central and South American populations, with a frequency of nearly 100%.[128] In Indigenous North American populations the frequency of type "A" ranges from 16% to 82%.[128] This suggests again that the initial Indigenous Americans evolved from an isolated population with a minimal number of individuals.[129][130]

The standard explanation for such a high population of Indigenous Americans with blood type O is genetic drift. Because the ancestral population of Indigenous Americans was numerically small, blood type diversity could have been reduced from generation to generation by the founder effect.[131] Other related explanations include the Bottleneck explanation which states that there were high frequencies of blood type A and B among Indigenous Americans but severe population decline during the 1500s and 1600s caused by the introduction of disease from Europe resulted in the massive death toll of those with blood types A and B. Coincidentally, a large amount of the survivors were type O.[131]

Distribution of ABO blood types
in various modern Indigenous American populations
Test results as of 2008[132]
PEOPLE GROUP O (%) A (%) B (%) AB (%)
Blackfoot Confederacy (Indigenous North American) 17 82 0 1
Bororo (Brazil)
 100 0 0 0
Eskimos (Alaska) 38 44 13 5
Inuit (Eastern Canada & Greenland) 54 36 23 8
Hawaiians (Polynesians, non-Indigenous American) 37 61 2 1
Indigenous North Americans (as a whole Native Nations/First Nations) 79 16 4 1
Maya (modern) 98 1 1 1
Navajo 73 27 0 0
Peru
 100 0 0 0

The Dia antigen of the Diego antigen system has been found only in Indigenous peoples of the Americas and East Asians, and in people with some ancestry from those groups. The frequency of the Dia antigen in various groups of Indigenous peoples of the Americas ranges from almost 50% to 0%.[133] Differences in the frequency of the antigen in populations of Indigenous people in the Americas correlate with major language families, modified by environmental conditions.[134]

See also

Wikimedia Commons has media related to Genetic studies of indigenous populations of the Americas.

Notes

  1. Mi'kmaq, Kickapoo and Meskwaki
    .
  2. ^ Q-M3=12.9; Q(xM3)=20.6.
  3. Navajo
    .
  4. ^ Q-M3=32.; Q3(xM3)=17.7.
  5. Kuna
    peoples.
  6. ^ Q-M3=6; Q(xM3)=25.
  7. ^ P1(xQ) 62.5%. While other studies identify this as R(xR2)/R1b,
    the subject remains controversial (see Hammer, Michael F. et al 2005)
  8. ^ Q-M3=8.2; Q(xQ-M3)=7.2.
  9. ^ Q-M3=40.5; Q(xM3)=5.4.
  10. ^ Gê ethnic groups: Gorotire, Kaigang, Kraho, Mekranoti and Xikrin.
  11. ^ Q-M3=90; Q(xM3)=2)
  12. ^ Q-M3=79; Q(xM3)=7.
  13. ^ Q-M3=11; Q(xM3)=67.
  14. ^ Q-M3=10.7; NWT01=44.6.
  15. Muscogee and Seminole
    .
  16. ^ Q-M3=50.0; Q(xM3)=25.0.
  17. ^ Q-M3=83; Q(xM3)=9.
  18. ^ Q-M3=89; Q(xM3)=11.
  19. ^ C3*=9; C3b=9
  20. ^ Q-M3=64; Q-MEH2*=9; Q-NWT01=9.
  21. Wayampi
    .
  22. ^ All examples of haplogroup Q were Q-M3.
  23. Huichol
    .
  24. ^ Q=M3
  25. ^ Q-M3=48; Q(xM3)=21.
  26. ^ Q-M3=86<; Q(xM3)=14.
  27. ^ Q=M3
  28. ^ Q-M3=33; Q(xM3)=48.

References

  1. ^ a b c Wendy Tymchuk (2008). "Learn about Y-DNA Haplogroup Q. Genebase Tutorials". Genebase Systems. Archived from the original on June 22, 2010. Retrieved November 21, 2009.
  2. S2CID 4939632
    .
  3. ISBN 978-1-136-23716-4. Archived
    from the original on January 30, 2016. Retrieved January 5, 2016.
  4. ^
    S2CID 4454580
    .
  5. PMID 20885818
    .
  6. ^
    PMID 17786201
    .
  7. PMID 21203537
    .
  8. ^
    PMID 12900798
    .
  9. ^
    PMID 9811914
    .
  10. ^
    PMID 14595095
    .
  11. PMID 10924403
    .
  12. doi:10.1146/annurev.anthro.33.070203.143932
    .
  13. PMID 1346260
    .
  14. ^ Wade, Nicholas (March 12, 2014). "Pause Is Seen in a Continent's Peopling". The New York Times. Archived from the original on April 9, 2021. Retrieved February 24, 2017.
  15. ISBN 978-0-19-508115-2. Archived
    from the original on May 10, 2021. Retrieved June 7, 2020.
  16. JSTOR 2155968
    .
  17. ISBN 978-1-4088-1091-0. Archived
    from the original on January 25, 2021. Retrieved August 5, 2019.
  18. PMID 23782551
    .
  19. ^
    PMID 18039031
    .
  20. ^
    PMID 17449208
    .
  21. ^
    ISBN 978-0-691-11532-0
    .
  22. ^
    PMID 15898833
    .
  23. ^ Wade, Nicholas (February 11, 2010). "Ancient Man In Greenland Has Genome Decoded". The New York Times. Archived from the original on March 8, 2021. Retrieved February 24, 2017.
  24. ^
    PMID 22801491
    .
  25. PMID 24522598
    .
  26. ^ "Ancient American's genome mapped". BBC News. February 14, 2014. Archived from the original on May 5, 2021. Retrieved June 20, 2018.
  27. PMID 23028843
    .
  28. PMID 26198033
    .
  29. PMID 26196601
    .
  30. ^
    PMID 27507099
    .
  31. ^ Vallini et al. 2022 (July 4, 2022). "Genetics and Material Culture Support Repeated Expansions into Paleolithic Eurasia from a Population Hub Out of Africa". Retrieved April 16, 2023.{{cite web}}: CS1 maint: numeric names: authors list (link)
  32. ISSN 2770-5005
    .
  33. doi:10.1101/2020.10.12.336628
    , retrieved March 29, 2024
  34. PMID 37524799
    .
  35. PMID 31467216
    .
  36. ^
    PMID 30415837
    .
  37. PMID 37057893
    .
  38. ^
    S2CID 235460793
    .
  39. ^ a b Sarkar, Anjali A. (June 18, 2021). "Ancient Human Genomes Reveal Peopling of the Americas". GEN - Genetic Engineering and Biotechnology News. Retrieved September 15, 2021. The team discovered that the Spirit Cave remains came from a Native American while dismissing a longstanding theory that a group called Paleoamericans existed in North America before Native Americans.
  40. ^ Sapiens (February 8, 2022). "A Genetic Chronicle of the First Peoples in the Americas". SAPIENS. Retrieved April 3, 2023. AROUND 36,000 years ago, a small group of people living in East Asia began to break off from the larger ancestral populations in the region. By about 25,000 years ago, the smaller group in East Asia itself split into two. One gave rise to a group referred to by geneticists as the ancient Paleo-Siberians, who stayed in Northeast Asia. The other became ancestral to Indigenous peoples in the Americas.
  41. PMID 9973301
    .
  42. ^ Blanco Verea; Alejandro José. Linajes del cromosoma Y humano: aplicaciones genético-poblacionales y forenses. Univ Santiago de Compostela. pp. 135–. GGKEY:JCW0ASCR364. Archived from the original on January 30, 2016. Retrieved June 15, 2011.
  43. PMID 14595095
    .
  44. ^
    PMID 10924403
    .
  45. S2CID 4647888
    .
  46. PMID 1346260
    .
  47. PMID 28251872
    .
  48. ^ a b "How the Subclades of Y-DNA Haplogroup Q are determined". Genebase Systems. 2009. Archived from the original on January 21, 2010. Retrieved November 22, 2009.
  49. ^ "Y-DNA Haplogroup Tree". Genebase Systems. 2009. Archived from the original on December 25, 2010. Retrieved November 21, 2009.
  50. ^ a b c "Frequency Distribution of Y-DNA Haplogroup Q1a3a-M3". GeneTree. 2010. Archived from the original on November 4, 2009. Retrieved January 30, 2010.
  51. PMID 26865217
    .
  52. ^ "Learning Center :: Genebase Tutorials". Genebase.com. October 22, 1964. Archived from the original on November 17, 2013.
  53. PMID 9050871
    .
  54. ISBN 978-1-59486-006-5. Archived
    from the original on January 30, 2016. Retrieved January 5, 2016.
  55. ^ Than, Ker (February 14, 2008). "New World Settlers Took 20,000-Year Pit Stop". National Geographic News. Archived from the original on August 26, 2014. Retrieved January 24, 2010.
  56. ^ Lovgren, Stefan (February 2, 2007). "First Americans Arrived Recently, Settled Pacific Coast, DNA Study Says". National Geographic News. Archived from the original on August 22, 2009. Retrieved February 2, 2010.
  57. ^ "First Americans Endured 20,000-Year Layover – Jennifer Viegas, Discovery News". May 10, 2017. Archived from the original on October 10, 2012. Retrieved November 18, 2009. page 2 Archived March 13, 2012, at the Wayback Machine
  58. PMID 16257940
    .
  59. ^
    PMID 18618732
    .
  60. PMID 16916941
    . "In most cases, there is widespread agreement about whether a particular haplogroup represents an ancient Native American lineage or post-1492 admixture, but the status of haplogroup R-M173 has recently been subject to some debate. Some authors have argued that this haplogroup represents a founding Native American lineage (Lell et al. 2002; Bortolini et al. 2003), whereas others suggest that it instead reflects recent European admixture (Tarazona-Santos and Santos 2002; Bosch et al. 2003; Zegura et al. 2004). In eastern North America, the pattern of haplotype variation within this haplogroup supports the latter hypothesis: R-M173 haplotypes do not cluster by population or culture area, as haplotypes in the other founding haplogroups do, and most match or are closely related to R-M173 haplotypes that are common in Europe but rare in Asia. This pattern is opposite than expected if the Native American R-M173 haplotypes were descended from Asian haplotypes and suggests that recent European admixture is responsible for the presence of haplogroup R-M173 in eastern North America."
  61. ^ Bolnick, Deborah Ann (2005). The Genetic Prehistory of Eastern North America: Evidence from Ancient and Modern DNA. University of California, Davis. p. 83. "Haplogroup R - M173 likely represents recent (post 1492) European admixture, as may P-M45* (Tarazona-Santos and Santos 2002; Bosch et al. 2003; Zegura et al. 2004)"
  62. ^ Raff 2022, pp. 59–60:"Y chromosome founder haplogroups in Native Americans include Q-M3 (and its sub-haplogroups, Q-CTS1780), and C3-MPB373 (potentially C- P39-Z30536). Other haplogroups found [sic] Native American populations, like R1b, were likely the result of post-European contact admixture (44)."
  63. ^ Malhi et al. 2008: "All individuals that did not belong to haplogroup Q and C were excluded from the Haplotype data set because these haplotypes are likely the result of non-native admixture (Tarazona-Santos and Santos, 2002; Zegura et al., 2004; Bolnick et al, 2006)...The frequency of haplogroup C is highest in Northwestern North America and the frequency of haplogroup R, the presence of which is attributed to European admixture, reaches its maximum in Northeastern North America."
  64. PMID 14595095
    .
  65. S2CID 28609578
    .
  66. PMID 16489223
    .
  67. ISBN 978-1-85109-818-7. Archived
    from the original on January 30, 2016. Retrieved January 5, 2016.
  68. ^ a b ISOGG, 2015 "Y-DNA Haplogroup C and its Subclades – 2015" Archived 2021-08-15 at the Wayback Machine (15 September 2015).
  69. ^
    PMID 14595095
    .
  70. ^
    S2CID 30220691
    .
  71. ^
    PMID 22586127
    .
  72. PMID 16337103
    .
  73. ^
    doi:10.1511/2000.23.772
    .
  74. S2CID 37139929
    .
  75. PMID 15638829
    .
  76. IFLScience
    . Retrieved May 24, 2023.
  77. ^
    S2CID 17049337
    .
  78. ^
    PMID 18335039
    .
  79. ISBN 978-0-940228-50-4. Archived
    from the original on January 30, 2016. Retrieved June 15, 2011.
  80. ISBN 978-94-007-2869-1
    .
  81. S2CID 85626735
    . "These studies have all reached the same conclusion and suggest that haplogroup X2a is likely to have originated in the same population(s) as the other American founder haplogroups, by virtue of having comparable coalescence dates and demographic histories" ... "X2a has not been found anywhere in Eurasia, and phylogeography gives us no compelling reason to think it is more likely to come from Europe than from Siberia. Furthermore, analysis of the complete genome of Kennewick Man, who belongs to the most basal lineage of X2a yet identified, gives no indication of recent European ancestry and moves the location of the deepest branch of X2a to the West Coast, consistent with X2a belonging to the same ancestral population as the other founder mitochondrial haplogroups."
  82. ^ "The peopling of the Americas: Genetic ancestry influences health". Scientific American. August 14, 2009. Archived from the original on September 14, 2011. Retrieved January 19, 2010 – via Phys.org.
  83. PMID 18313026
    .
  84. ISBN 978-0-520-94315-5. Archived
    from the original on January 30, 2016. Retrieved January 5, 2016.
  85. ^ "An mtDNA view of the peopling of the world by Homo sapiens". Cambridge DNA. 2009. Archived from the original on May 11, 2011. Retrieved April 29, 2010.
  86. PMID 14574647
    .
  87. ^ "An mtDNA view of the peopling of the world by Homo sapiens". Cambridge DNA Services. 2007. Archived from the original on May 11, 2011. Retrieved June 1, 2011.
  88. S2CID 35654242
    .
  89. ^
    PMID 6455922
    .
  90. ^
    PMID 16353217
    .
  91. PMID 24256729
    .
  92. PMID 22024980
    .
  93. PMID 27051878
    .
  94. ^ a b c "Direct genetic evidence of founding population reveals story of first Native Americans". University of Cambridge. January 3, 2018. Archived from the original on September 25, 2018. Retrieved October 15, 2018.
  95. ^ "Direct genetic evidence of founding population reveals story of first Native Americans". Archived from the original on November 5, 2018. Retrieved October 15, 2018.
  96. PMID 15022364
    .
  97. ^ Neves, W.A.; Powell, J.F.; Ozolins, E.G. (1999). "Extra-continental morphological affinities of Palli Aike, southern Chile". Interciencia. 24 (4): 258–263. Archived from the original on July 9, 2021. Retrieved July 8, 2021.
  98. PMID 9050871
    .
  99. JSTOR 41102194
    .
  100. ISBN 978-0-88864-999-7
    .
  101. PMID 26580202
    .
  102. PMID 28060931
    .
  103. S2CID 17671309
    .
  104. ISBN 978-0-465-00071-5
    . Miscegenation, a term for sexual relations across racial lines; no longer in use because of its racist implications
  105. ISBN 978-0-8420-5060-9. Archived
    from the original on August 15, 2021. Retrieved February 24, 2010.
  106. ^ Chasteen (2004:4): "between the White elite and the mass of [Indigenous Americans] and Negroes there existed by 1700 a thin stratum of population subject neither to Negro slavery nor [Indigenous American] tutelage, consisting of the products of racial interbreeding among Whites, [Indigenous Americans], and Negroes and defined as mestizos, mulattoes and zambos (mixture of [Indigenous American] and Negro) and their many combinations."
  107. PMID 10721616
    .
  108. ^ Sweet, Frank W (2004). "Afro-European Genetic Admixture in the United States". Essays on the Color Line and the One-Drop Rule. Backintyme Essays. Archived from the original on January 4, 2010. Retrieved February 24, 2010.
  109. ISBN 978-0-939479-23-8. Archived
    from the original on February 17, 2010. Retrieved February 24, 2010.
  110. ^ Soong, Roland (1999). "Racial Classifications in Latin America". Latin American Media. Archived from the original on April 30, 2010. Retrieved February 25, 2010.
  111. ^ Brehaut, Harry B (1998). "The Red River Cart and Trails: The Fur Trade". Manitoba Historical Society. Archived from the original on July 9, 2011. Retrieved February 24, 2010.
  112. ^ "Who are Métis ?". Métis National Council. 2001. Archived from the original on February 26, 2010. Retrieved February 24, 2010.
  113. ^
    S2CID 201778441
    .
  114. ^ Furukawa, Julia (May 22, 2023). "Review of genealogies, other records fails to support local leaders' claims of Abenaki ancestry". New Hampshire Public Radio. Retrieved July 7, 2023.
  115. ^ Adams, Paul (July 10, 2011). "Blood quantum influences Native American identity". BBC News. Archived from the original on January 29, 2023. Retrieved October 22, 2017.
  116. ^ Bureau, U.S. Census. "U.S. Census website". United States Census Bureau. Archived from the original on December 27, 1996. Retrieved October 22, 2017.
  117. ^ "Why Do So Many People Claim They Have Cherokee In Their Blood? - Nerve". www.nerve.com. Archived from the original on October 22, 2017. Retrieved October 22, 2017.
  118. ^ Smithers, Gregory D. (October 1, 2015). "Why Do So Many Americans Think They Have Cherokee Blood?". Slate. Archived from the original on October 5, 2018. Retrieved October 22, 2017.
  119. ^ "The Cherokee Syndrome - Daily Yonder". www.dailyyonder.com. February 10, 2011. Archived from the original on October 21, 2017. Retrieved October 22, 2017.
  120. ^ a b Hitt, Jack (August 21, 2005). "The Newest Indians". The New York Times. Archived from the original on October 21, 2017. Retrieved October 22, 2017 – via www.nytimes.com.
  121. ^ Nieves, Evelyn (March 3, 2007). "Putting to a Vote the Question 'Who Is Cherokee?'". The New York Times. Archived from the original on August 30, 2017. Retrieved October 22, 2017 – via www.nytimes.com..
  122. ^ "What Percentage Indian Do You Have to Be in Order to Be a Member of a Tribe or Nation? - Indian Country Media Network". indiancountrymedianetwork.com. Archived from the original on October 21, 2017. Retrieved October 22, 2017.. "Disappearing Indians, Part II: The Hypocrisy of Race In Deciding Who's Enrolled - Indian Country Media Network". indiancountrymedianetwork.com. Archived from the original on September 22, 2017. Retrieved October 22, 2017.
  123. ^
    doi:10.1126/science.aal0382
    .
  124. PMID 12981234
    .
  125. ^
    PMID 13505351
    .
  126. NAID 10008616088
    .
  127. PMID 16787828
    .
  128. ^ a b c "Distribution of Blood Types". Behavioral Sciences Department, Palomar College. 2010. Archived from the original on February 21, 2006. Retrieved March 14, 2010.
  129. PMID 19862808
    .
  130. PMID 13362488
    .
  131. ^
    PMID 18618657
    .
  132. ^ "Racial and Ethnic Distribution of ABO Blood Types". BloodBook. 2008. Archived from the original on March 4, 2010. Retrieved March 31, 2010.
  133. PMID 15373634
    .
  134. PMID 26148209
    .

Further reading

Retrieved from "https://en.wikipedia.org/w/index.php?title=Genetic_history_of_the_Indigenous_peoples_of_the_Americas&oldid=1219848498"