George Emil Palade
George Emil Palade | |
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Born | George Emil Palade November 19, 1912 |
Died | October 8, 2008 Del Mar, California, U.S. | (aged 95)
Nationality | Romanian, American |
Alma mater | Carol Davila School of Medicine |
Known for |
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Spouses | |
Awards |
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Scientific career | |
Fields | Cell biology |
Institutions | |
Notable students | Günter Blobel[2] |
George Emil Palade
Palade also received the U.S.
Education and early life
George Emil Palade was born on November 19, 1912, in Iași, Romania; his father was a professor of philosophy at the University of Iași and his mother was a high school teacher. Palade received his M.D. in 1940 from the Carol Davila School of Medicine in Bucharest.
Career and research
Palade was a member of the faculty at
In 1952, Palade became a
In 1970, he was awarded the Louisa Gross Horwitz Prize from Columbia University together with Renato Dulbecco winner of 1975 Nobel Prize in Physiology or Medicine "for discoveries concerning the functional organization of the cell that were seminal events in the development of modern cell biology",[13] related to his previous research carried out at the Rockefeller Institute for Medical Research.[14] His Nobel lecture, delivered on December 12, 1974, was entitled: "Intracellular Aspects of the Process of Protein Secretion",[15] published in 1992 by the Nobel Prize Foundation,[16][17] He was elected an Honorary member of the Romanian Academy in 1975. He received the Golden Plate Award of the American Academy of Achievement in 1975.[18] In 1981, Palade became a founding member of the World Cultural Council.[19] In 1985, he became the founding editor of the Annual Review of Cell and Developmental Biology.[20] In 1988 he was also elected an Honorary Member of the American-Romanian Academy of Arts and Sciences (ARA).
Palade was the first Chairman of the Department of Cell Biology at Yale University. Presently, the Chair of Cell Biology at Yale is named the "George Palade Professorship".
At the Rockefeller Institute for Medical Research, Palade used
He focused on
Palade's coworkers and approach in the 1960s
The following is a concise excerpt from Palade's Autobiography appearing in the Nobel Award documents[10]
In the 1960s, I continued the work on the secretory process using in parallel or in succession two different approaches. The first relied exclusively on cell fractionation, and was developed in collaboration with Philip Siekevitz, Lewis Joel Greene, Colvin Redman, David Sabatini and Yutaka Tashiro; it led to the characterization of the zymogen granules and to the discovery of the segregation of secretory products in the cisternal space of the endoplasmic reticulum. The second approach relied primarily on radioautography, and involved experiments on intact animals or pancreatic slices which were carried out in collaboration with Lucien Caro and especially James Jamieson. This series of investigations produced a good part of our current ideas on the synthesis and intracellular processing of proteins for export. A critical review of this line of research is presented in the Nobel Lecture.[15]
One notes also that the
Personal life
Palade's widow Marilyn Farquhar was a cell biologist at the University of California, San Diego.[23]
References
- ^ a b "Fellowship of the Royal Society 1660–2015". London: Royal Society. Archived from the original on 2015-10-15.
- ^ "The Palade Symposium: Celebrating Cell Biology at Its Best". Molbiolcell.org. Retrieved on 2016-06-10.
- ^ a b "Prof. George Palade: Nobel prize-winner whose work laid the foundations for modern molecular cell biology". The Independent. 22 October 2008. Archived from the original on October 19, 2010. Retrieved 2011-02-09. Archived. (Internet Archive copy)
- ^ S2CID 23177212. Retrieved 25 March 2023.
- ^ Grens, Kerry (February 1, 2014). "Palade Particles, 1955". The Scientist.
- ^ Pollack, Andrew (October 9, 2008) George Palade, Nobel Winner for Work Inspiring Modern Cell Biology, Dies at 95. New York Times
- ^ George E. Palade on Nobelprize.org , accessed 11 October 2020
- PMID 17367496.
- ^ "Honorary Fellows Past and Present". Royal Microscopical Society. Retrieved 5 June 2018.
- ^ a b c "George E. Palade – Autobiography". Nobelprize.org. 2008-10-07. Retrieved 2011-04-03.
- ^ "George E. Palade - Autobiography". 2006-07-16. Archived from the original on 2006-07-16. Retrieved 2019-08-16.
- ^ Professor George E. Palade – web page at the University of California at San Diego, School of medicine Archived March 30, 2004, at the Wayback Machine
- ^ "The 1974 Nobel Prize for Medicine". Nobelprize.org. Retrieved 2011-04-03.
- ^ Nobel Laureates Affiliated with The Rockefeller University. rockefeller.edu
- ^ a b "Nobel lecture". Nobelprize.org. 1974-12-12. Retrieved 2011-04-03.
- ISBN 981-02-0791-3
- ^ Nobel Lectures in Physiology or Medicine Archived July 14, 2008, at the Wayback Machine
- American Academy of Achievement.
- ^ "About Us". World Cultural Council. Retrieved November 8, 2016.
- .
- PMID 14228505.
- ^ 2009 Nobel Prize in Chemistry, Nobel Foundation
- PMID 19065752.
Bibliography
- Singer, Manfred V (2003). "Legacy of a distinguished scientist: George E. Palade". Pancreatology. 3 (6): 518–9. S2CID 36839347.
- Haulică, I (2002). "[Professor doctor George Emil Palade at 90 years of age]". Revista medico-chirurgicală a Societăţii de Medici şi Naturalişti din Iaşi. 107 (2): 223–5. PMID 12638263.
- Tartakoff, Alan M (November 2002). "George Emil Palade: charismatic virtuoso of cell biology". Nature Reviews Molecular Cell Biology. 3 (11): 871–6. S2CID 2844447.
- Motta, P M (2001). "George Emil Palade and Don Wayne Fawcett and the development of modern anatomy, histology and contemporary cell biology". Italian Journal of Anatomy and Embryology. 106 (2 Suppl 1): XXI–XXXVIII. PMID 11730003.
- Farquhar, M G; Wissig S L; Palade G E (December 1999). "Glomerular permeability I. Ferritin transfer across the normal glomerular capillary wall. 1961". Journal of the American Society of Nephrology. 10 (12): 2645–62. PMID 10589706.
- Raju, T N (October 1999). "The Nobel chronicles. 1974: Albert Claude (1899–1983), George Emil Palade (b 1912), and Christian Réne de Duve (b 1917)". S2CID 54323049.
- Sabatini, D D (October 1999). "George E. Palade: charting the secretory pathway". Trends in Cell Biology. 9 (10): 413–7. PMID 10481180.
- Motta, P M (1998). "George Emil Palade and Don Wayne Fawcett and the development of modern anatomy, histology and contemporary cell biology". PMID 9719773.
- Porter, K R (July 1983). "An informal tribute to George E. Palade". The Journal of Cell Biology. 97 (1): D3–7. PMID 6345553.
- Tashiro, Y (January 1975). "[Accomplishment of Drs. Albert Calude and George E. Palade and the birth of cell biology]". Tanpakushitsu Kakusan Koso. 20 (1): 74–6. PMID 1094498.
- Magner, J W; Ritchie E H; Cahill S C (January 1975). "Current medical literature". Journal of the Indian Medical Association. 64 (1): 20–2. PMID 1094070.
- "George E. Palade". Triangle. 9 (6): 229–30. 1970. PMID 4927031.
External links
- George E. Palade on Nobelprize.org