Gestational diabetes

Source: Wikipedia, the free encyclopedia.
Gestational diabetes
Other namesGestational diabetes mellitus (GDM)
Diabetic diet, exercise, insulin injections[2]
Frequency~6% of pregnancies[3]

Gestational diabetes is a condition in which a person without

macrosomia, of having hypoglycemia after birth, and of jaundice.[2] If untreated, diabetes can also result in stillbirth.[2] Long term, children are at higher risk of being overweight and of developing type 2 diabetes.[2]

Gestational diabetes can occur during pregnancy because of

prenatal visit.[2]

Maintenance of healthy weight and exercising before pregnancy assist in prevention.

diabetic diet, exercise, medication (such as metformin), and sometimes insulin injections.[2] Most people manage blood sugar with diet and exercise.[3] Blood sugar testing among those who are affected is often recommended four times a day.[3] Breastfeeding is recommended as soon as possible after birth.[2]

Gestational diabetes affects 3–9% of pregnancies, depending on the population studied.

Asians, American Indians, Indigenous Australians, and Pacific Islanders are at higher risk.[3][2] However, the variations in prevalence are also due to different screening strategies and diagnostic criteria being used. In 90% of cases, gestational diabetes resolves after the baby is born.[2] Affected people, however, are at an increased risk of developing type 2 diabetes.[3]

Classification

Gestational diabetes is formally defined as "any degree of

glucose intolerance with onset or first recognition during pregnancy".[4] This definition acknowledges the possibility that a woman may have previously undiagnosed diabetes mellitus, or may have developed diabetes coincidentally with pregnancy. Whether symptoms subside after pregnancy is also irrelevant to the diagnosis.[5]
A woman is diagnosed with gestational diabetes when glucose intolerance continues beyond 24 to 28 weeks of gestation.

The White classification, named after Priscilla White,[6] who pioneered research on the effect of diabetes types on perinatal outcome, is widely used to assess maternal and fetal risk.[7] It distinguishes between gestational diabetes (type A) and pregestational diabetes (diabetes that existed prior to pregnancy). These two groups are further subdivided according to their associated risks and management.[8]

The two subtypes of gestational diabetes under this classification system are:

  • Type A1: abnormal oral glucose tolerance test (OGTT), but normal blood glucose levels during fasting and two hours after meals; diet modification is sufficient to control glucose levels
  • Type A2: abnormal OGTT compounded by abnormal glucose levels during fasting and/or after meals; additional therapy with insulin or other medications is required

Diabetes which existed prior to pregnancy is also split up into several subtypes under this system:[medical citation needed
]

An early age of onset or long-standing disease comes with greater risks, hence the first three subtypes.[medical citation needed]

Two other sets of criteria are available for diagnosis of gestational diabetes, both based on blood-sugar levels.[9]

Criteria for diagnosis of gestational diabetes, using the 100 gram

Glucose Tolerance Test, according to Carpenter and Coustan:[10]

  • Fasting 95 mg/dl
  • 1 hour 180 mg/dl
  • 2 hours 155 mg/dl
  • 3 hours 140 mg/dl

Criteria for diagnosis of gestational diabetes according to National Diabetes Data Group:[9][11]

  • Fasting 105 mg/dl
  • 1 hour 190 mg/dl
  • 2 hours 165 mg/dl
  • 3 hours 145 mg/dl

Risk factors

Classical risk factors for developing gestational diabetes are:[12]

In addition to this, statistics show a double risk of GDM in smokers.[18] Some studies have looked at more controversial potential risk factors, such as short stature.[19]

About 40–60% of women with GDM have no demonstrable risk factor; for this reason many advocate to screen all women.

yeast infections and blurred vision.[21]

Pathophysiology

plasma membrane and influx of glucose (3), glycogen synthesis (4), glycolysis (5) and fatty acid
synthesis (6).

The precise mechanisms underlying gestational diabetes remain unknown. The hallmark of GDM is increased insulin resistance. Pregnancy hormones and other factors are thought to interfere with the action of insulin as it binds to the insulin receptor. The interference probably occurs at the level of the cell signaling pathway beyond the insulin receptor.[22] Since insulin promotes the entry of glucose into most cells, insulin resistance prevents glucose from entering the cells properly. As a result, glucose remains in the bloodstream, where glucose levels rise. More insulin is needed to overcome this resistance; about 1.5–2.5 times more insulin is produced than in a normal pregnancy.[22]

Insulin resistance is a normal phenomenon emerging in the second trimester of pregnancy, which in cases of GDM progresses thereafter to levels seen in a non-pregnant woman with type 2 diabetes. It is thought to secure glucose supply to the growing fetus. Women with GDM have an insulin resistance that they cannot compensate for with increased production in the β-cells of the pancreas.

tumor necrosis factor alpha, and resistin are involved in the decrease in insulin sensitivity occurring during pregnancy, with tumor necrosis factor alpha named as the strongest independent predictor of insulin sensitivity in pregnancy.[23] An inverse correlation with the changes in insulin sensitivity from the time before conception through late gestation accounts for about half of the variance in the decrease in insulin sensitivity during gestation: in other words, low levels or alteration of TNF alpha factors corresponds with a greater chance of, or predisposition to, insulin resistance or sensitivity.[24]

It is unclear why some women are unable to balance insulin needs and develop GDM; however, a number of explanations have been given, similar to those in type 2 diabetes:

mutations, obesity, along with other mechanisms.[25]

Though the clinical presentation of gestational diabetes is well characterized, the biochemical mechanism behind the disease is not well known. One proposed biochemical mechanism involves insulin-producing β-cell adaptation controlled by the HGF/c-MET signaling pathway. β-cell adaption refers to the change that pancreatic islet cells undergo during pregnancy in response to maternal hormones in order to compensate for the increased physiological needs of mother and baby. These changes in the β-cells cause increased insulin secretion as a result of increased β-cell proliferation.[26] HGF/

c-MET has also been implicated in β-cell regeneration, which suggests that HGF/c-MET may help increase β-cell mass in order to compensate for insulin needs during pregnancy. Recent studies support that loss of HGF/c-MET signaling results in aberrant β-cell adaptation.[27][28]

c-MET is a receptor tyrosine kinase (RTK) that is activated by its ligand, hepatocyte growth factor (HGF), and is involved in the activation of several cellular processes. When HGF binds c-MET, the receptor homodimerizes and self-phosphorylates to form an SH2 recognition domain. The downstream pathways activated include common signaling molecules such as RAS and MAPK, which affect cell motility, and cell cycle progression.[29]

Studies have shown that HGF is an important signaling molecule in stress related situations where more insulin is needed. Pregnancy causes increased insulin resistance and so a higher insulin demand. The β-cells must compensate for this by either increasing insulin production or proliferating. If neither of the processes occur, then markers for gestational diabetes are observed. It has been observed that pregnancy increases HGF levels, showing a correlation that suggests a connection between the signaling pathway and increased insulin needs. In fact, when no signaling is present, gestational diabetes is more likely to occur.[27]

The exact mechanism of HGF/c-MET regulated β-cell adaptation is not yet known but there are several hypotheses about how the signaling molecules contribute to insulin levels during pregnancy. c-MET may interact with FoxM1, a molecule important in the cell cycle, as

p27 as the protein levels increase with c-MET is not present. Another hypothesis says that c-MET may control β-cell apoptosis because a lack of c-MET causes increases cell death but the signaling mechanisms have not been elucidated.[28]

Although the mechanism of HGF/c-MET control of gestational diabetes is not yet well understood, there is a strong correlation between the signaling pathway and the inability to produce an adequate amount of insulin during pregnancy and thus it may be the target for future diabetic therapies.[27][28]

Because glucose travels across the placenta (through

macrosomia). After birth, the high glucose environment disappears, leaving these newborns with ongoing high insulin production and susceptibility to low blood glucose levels (hypoglycemia).[30]

Screening

Tests for gestational diabetes
Non-challenge blood glucose test
  • Fasting glucose test
  • 2-hour
    postprandial
    (after a meal) glucose test
  • Random glucose test
Screening glucose challenge test
Oral glucose tolerance test
(OGTT)

A number of screening and diagnostic tests have been used to look for high levels of

polycystic ovarian syndrome or acanthosis nigricans).[30]

Non-challenge blood glucose tests involve measuring glucose levels in blood samples without challenging the subject with glucose solutions. A blood glucose level is determined when fasting, two hours after a meal, or simply at any random time. In contrast, challenge tests involve drinking a glucose solution and measuring glucose concentration thereafter in the blood; in diabetes, they tend to remain high. The glucose solution has a very sweet taste which some women find unpleasant; sometimes, therefore, artificial flavours are added. Some women may experience nausea during the test, and more so with higher glucose levels.[31][32]

There is currently not enough research to show which way is best at diagnosing gestational diabetes.[33] Routine screening of women with a glucose challenge test may find more women with gestational diabetes than only screening women with risk factors.[34] Hemoglobin A1c (HbA1c) is not recommended for diagnosing gestational diabetes, as it's a less reliable marker of glycemia during pregnancy than oral glucose tolerance testing (OGTT).[35]

Because women diagnosed with Gestational Diabetes (GDM) during pregnancy are at an increased risk for developing Type 2 Diabetes Mellitus after pregnancy, post pregnancy glucose tolerance testing is needed.[36] Based on the recent meta-analysis conducted by the Patient-Centered Outcomes Research Institute, research has shown that post pregnancy testing reminders are associated with greater adherence to oral glucose tolerance testing up to 1 year postpartum. [37]

Pathways

Opinions differ about optimal screening and diagnostic measures, in part due to differences in population risks, cost-effectiveness considerations, and lack of an

evidence base to support large national screening programs.[38] The most elaborate regimen entails a random blood glucose test during a booking visit, a screening glucose challenge test around 24–28 weeks' gestation, followed by an OGTT if the tests are outside normal limits. If there is a high suspicion, a woman may be tested earlier.[5]

In the

U.S. Preventive Services Task Force found there is insufficient evidence to recommend for or against routine screening,[43] and a 2017 a Cochrane review found that there is not evidence to determine which screening method is best for women and their babies.[34]

Some pregnant women and careproviders choose to forgo routine screening due to the absence of risk factors, however this is not advised due to the large proportion of women who develop gestational diabetes despite having no risk factors present and the dangers to the mother and baby if gestational diabetes remains untreated.[20]

Non-challenge blood glucose tests

When a plasma glucose level is found to be higher than 126 mg/dL (7.0 mmol/L) after fasting, or over 200 mg/dL (11.1 mmol/L) on any occasion, and if this is confirmed on a subsequent day, the diagnosis of GDM is made, and no further testing is required.

false positive rates.[44][45][46]

Screening glucose challenge test

The screening glucose challenge test (sometimes called the O'Sullivan test) is performed between 24 and 28 weeks, and can be seen as a simplified version of the oral glucose tolerance test (OGTT). No previous fasting is required for this screening test,[47] in contrast to the OGTT. The O'Sullivan test involves drinking a solution containing 50 grams of glucose, and measuring blood levels one hour later.[48]

If the cut-off point is set at 140 mg/dL (7.8 mmol/L), 80% of women with GDM will be detected.[5] If this threshold for further testing is lowered to 130 mg/dL, 90% of GDM cases will be detected, but there will also be more women who will be subjected to a consequent OGTT unnecessarily.

Oral glucose tolerance test

A standardized

oral glucose tolerance test (OGTT)[49] should be done in the morning after an overnight fast of between 8 and 14 hours. During the three previous days the subject must have an unrestricted diet (containing at least 150 g carbohydrate
per day) and unlimited physical activity. The subject should remain seated during the test and should not smoke throughout the test.

IADPSG (International Association of Diabetes and Pregnancy Study Groups) has developed diagnostic criteria for GDM, based on the results of adverse pregnancy outcomes in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study.[50] These were recommended by WHO 2013.[51]

According to these gestational diabetes mellitus should be diagnosed at any time in pregnancy if one of the following criteria are met, using a 75 g glucose OGTT:

  • Fasting blood glucose level ≥92 mg/dL (5.1 mmol/L)
  • 1 hour blood glucose level ≥180 mg/dL (10 mmol/L)
  • 2 hour blood glucose level ≥153 mg/dL (8.5 mmol/L)

Urinary glucose testing

Women with GDM may have high glucose levels in their urine (

positive predictive value is around 20%.[53][54]

Prevention

Vitamin D supplementation during pregnancy may help to prevent gestational diabetes.[55] A 2015 review found that when done during pregnancy moderate physical exercise is effective for the prevention of gestational diabetes.[56] A 2014 review however did not find a significant effect.[57] It is uncertain if additional dietary advice interventions help to reduce the risk of gestational diabetes.[58] However, data from the Nurses' Health Study shows that adherence to a healthy plant-based diet is associated with lower risk for GDM.[59] Diet and physical activity interventions designed to prevent excessive gestational weight gain reduce the rates of gestational diabetes. However, the impact of these interventions varies with the body-mass index of the person as well as with the region in which the studies were performed.[60]

Moderate-quality evidence suggest that there is a reduced risk of gestational diabetes mellitus and caesarean section with combined diet and exercise interventions during pregnancy as well as reductions in gestational weight gain, compared with standard care.[61]

A 2023 review found that a plant-based diet (including fruits, vegetables, whole grains, nuts and seeds, and tea) rich in phytochemicals lowers the risk of GDM.[62] A Cochrane review, updated 2023, stated that myo‐inositol has a potential beneficial effect of improving insulin sensitivity, which suggested that it may be useful for women in preventing gestational diabetes″.[63]

It has been suggested that for women who have had gestational diabetes, diet, exercise, education, and lifestyle changes between pregnancies may lower their chances of having gestational diabetes again in future pregnancies.[64] However, there is no research to show whether interventions between pregnancies lower the number of women who develop gestational diabetes again.[64]

Management

Main article: Diabetes management
A kit with a glucose meter and diary used by a woman with gestational diabetes

Treatment of GDM with diet and insulin reduces health problems mother and child.

inductions of labour.[65]

A repeat OGTT should be carried out 6 weeks after delivery, to confirm the diabetes has disappeared. Afterwards, regular screening for type 2 diabetes is advised.[12]

Lifestyle interventions include exercise, diet advice, behavioural interventions, relaxation, self-monitoring glucose, and combined interventions.

probiotics but it is very uncertain if there are any benefits in terms of blood glucose levels, high blood pressure disorders or induction of labour.[67]

If a

G.I. Diet, exercise, and oral medication are inadequate to control glucose levels, insulin therapy may become necessary.[citation needed
]

The development of macrosomia can be evaluated during pregnancy by using sonography. Women who use insulin, with a history of stillbirth, or with hypertension are managed like women with overt diabetes.[20]

Lifestyle

Counselling before pregnancy (for example, about preventive

antidiabetic drugs, most commonly insulin therapy.[citation needed
]

Any diet needs to provide sufficient calories for pregnancy, typically 2,000–2,500 kcal with the exclusion of simple carbohydrates.

G.I. Diet. Since insulin resistance is highest in mornings, breakfast carbohydrates need to be restricted more.[12]

The Mediterranean diet may be associated with reduced incidence of gestational diabetes.[69] However, there is not enough evidence to indicate if one type of dietary advice is better than another.[70]

Regular moderately intense physical exercise is advised, although there is no consensus on the specific structure of exercise programs for GDM.[12][71] Pregnant women who exercise have lower blood sugar levels when fasting and after meals compared to those who do not exercise.[72] It is not clear which form of exercise is best when pregnant.[72]

Self monitoring can be accomplished using a handheld capillary glucose dosage system. Compliance with these glucometer systems can be low.[73] There is not a lot of research into what target blood sugar levels should be for women with gestational diabetes and targets recommended to women vary around the world.[74] Target ranges advised by the Australasian Diabetes in Pregnancy Society are as follows:[12]

  • fasting capillary blood glucose levels <5.5 mmol/L
  • 1 hour postprandial capillary blood glucose levels <8.0 mmol/L
  • 2 hour postprandial blood glucose levels <6.7 mmol/L

Regular blood samples can be used to determine

HbA1c levels, which give an idea of glucose control over a longer time period.[12]

Research suggests a possible benefit of breastfeeding to reduce the risk of diabetes and related risks for both mother and child.[75]

Medication

If monitoring reveals failing control of glucose levels with these measures, or if there is evidence of complications like excessive fetal growth, treatment with insulin might be necessary. This is most commonly fast-acting insulin given just before eating to blunt glucose rises after meals.

Cochrane review (updated in 2023) concluded that quality evidence is not yet available to determine the best blood sugar range for improving health for pregnant women with GDM and their babies.[74]

There is some evidence that certain medications by mouth might be safe in pregnancy, or at least, are less dangerous to the developing fetus than poorly controlled diabetes. When comparing which diabetes tablets (medication by mouth) work best and are safest, there is not enough quality research to support one medication over another.

glyburide.[78] If blood glucose cannot be adequately controlled with a single agent, the combination of metformin and insulin may be better than insulin alone.[78] Another review found good short term safety for both the mother and baby with metformin but unclear long term safety.[79]

People may prefer metformin by mouth to insulin injections.[3] Treatment of polycystic ovarian syndrome with metformin during pregnancy has been noted to decrease GDM levels.[80]

Almost half of the women did not reach sufficient control with metformin alone and needed supplemental therapy with insulin; compared to those treated with insulin alone, they required less insulin, and they gained less weight.[81] With no long-term studies into children of women treated with the drug, there remains a possibility of long-term complications from metformin therapy.[3] Babies born to women treated with metformin have been found to develop less visceral fat, making them less prone to insulin resistance in later life.[81]

Prognosis

Gestational diabetes generally resolves once the baby is born. Based on different studies, the chances of developing GDM in a second pregnancy, if a woman had GDM in her first pregnancy, are between 30 and 84%, depending on ethnic background. A second pregnancy within one year of the previous pregnancy has a large likelihood of GDM recurrence.[82]

Women diagnosed with gestational diabetes have an increased risk of developing diabetes mellitus in the future. The risk is highest in women who needed insulin treatment, had

(LADA).[84]

Children of women with GDM have an increased risk for childhood and adult obesity and an increased risk of glucose intolerance and type 2 diabetes later in life.[89] This risk relates to increased maternal glucose values.[90] It is currently unclear how much genetic susceptibility and environmental factors contribute to this risk, and whether treatment of GDM can influence this outcome.[91]

Relative benefits and harms of different oral anti-diabetic medications are not yet well understood as of 2017.[77]

There are scarce statistical data on the risk of other conditions in women with GDM; in the Jerusalem Perinatal study, 410 out of 37,962 women were reported to have GDM, and there was a tendency towards more breast and pancreatic cancer, but more research is needed to confirm this finding.[92][93]

Research is being conducted to develop a web-based clinical decision support system for GDM prediction using machine learning techniques. Results so far demonstrated great potential in clinical practicality for automatic GDM prognosis.[94]

Complications

GDM poses a risk to mother and child. This risk is largely related to uncontrolled blood glucose levels and its consequences. The risk increases with higher blood glucose levels.[95] Treatment resulting in better control of these levels can reduce some of the risks of GDM considerably.[73]

The two main risks GDM imposes on the baby are growth abnormalities and chemical imbalances after birth, which may require admission to a

ventouse and caesarean section) or problems during vaginal delivery (such as shoulder dystocia). Macrosomia may affect 12% of normal women compared to 20% of women with GDM.[30] However, the evidence for each of these complications is not equally strong; in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study for example, there was an increased risk for babies to be large but not small for gestational age in women with uncontrolled GDM.[95] In a recent birth cohot study of 5150 deliveries, a research group active at the University of Helsinki and Helsinki University Hospital, Finland demonstrated that the mother's GDM is an independent factor that increases the risk of fetal hypoxia, during labour. The study was published in the Acta Diabetologica in June 2021.[97] Another finding was that GDM increased the susceptibility of the fetus to intrapartum hypoxia, regardless of the size of the fetus.[97] The risk of hypoxia and the resulting risk of poor condition in newborn infants was nearly 7-fold in the fetuses of mothers with GDM compared to the fetuses of non-diabetic mothers.[97] Furthermore, according to the findings, the risk of needing to perform resuscitation on the newborn after birth was 10-fold.[97]

Another finding was that gestational diabetes increased the susceptibility of the fetus to intrapartal hypoxia, regardless of the size of the fetus.[citation needed]

"The risk of hypoxia and the resulting risk of poor condition in newborn infants was nearly seven-fold in the fetuses of mothers with gestational diabetes compared to the fetuses of non-diabetic mothers," says researcher Mikko Tarvonen. According to the findings, the risk of needing to perform resuscitation on the newborn was ten-fold.Research into complications for GDM is difficult because of the many confounding factors (such as obesity). Labelling a woman as having GDM may in itself increase the risk of having an unnecessary caesarean section.[98][99]

Neonates born from women with consistently high blood sugar levels are also at an increased risk of low blood glucose (

hypomagnesemia).[100] Untreated GDM also interferes with maturation, causing dysmature babies prone to respiratory distress syndrome due to incomplete lung maturation and impaired surfactant synthesis.[100]

Unlike pre-gestational diabetes, gestational diabetes has not been clearly shown to be an independent risk factor for birth defects. Birth defects usually originate sometime during the first trimester (before the 13th week) of pregnancy, whereas GDM gradually develops and is least pronounced during the first and early second trimester. Studies have shown that the offspring of women with GDM are at a higher risk for congenital malformations.[101][102][103] A large case-control study found that gestational diabetes was linked with a limited group of birth defects, and that this association was generally limited to women with a higher body mass index (≥ 25 kg/m2).[104] It is difficult to make sure that this is not partially due to the inclusion of women with pre-existent type 2 diabetes who were not diagnosed before pregnancy.

Because of conflicting studies, it is unclear at the moment whether women with GDM have a higher risk of

preeclampsia.[105] In the HAPO study, the risk of preeclampsia was between 13% and 37% higher, although not all possible confounding factors were corrected.[95]

Epidemiology

Gestational diabetes affects 3–10% of pregnancies, depending on the population studied.[3][106]

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External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=Gestational_diabetes&oldid=1212238815"