Glycoprotein IIb/IIIa inhibitors

In

Several GpIIb/IIIa inhibitors exist:

• abciximab (abcixifiban) (ReoPro)
• eptifibatide (Integrilin)
• tirofiban (Aggrastat)
• roxifiban
• orbofiban

Use

Glycoprotein IIb/IIIa inhibitors are frequently used during percutaneous coronary intervention (angioplasty with or without intracoronary stent placement).

They work by preventing platelet aggregation and thrombus formation. They do so by inhibition of the GpIIb/IIIa receptor on the surface of the platelets.

They may also be used to treat acute coronary syndromes, without percutaneous coronary intervention, depending on TIMI risk.

They should be given intravenously. The oral form is associated with increased mortality and hence should not be given.

In integrin nomenclature glycoprotein IIb/IIIa is called αIIbβ3.

History

Their development arose from the understanding of Glanzmann's thrombasthenia, a condition in which the GpIIb/IIIa receptor is deficient or dysfunctional.^[1]

References