Gonad

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Gonad
Cyprinus carpio (common carp) placed in dissecting dish
Identifiers
MeSHD006066
FMA18250
Anatomical terminology]

A gonad, sex gland, or reproductive gland

hermaphroditic animals (also some intersex humans) have a type of gonad called an ovotestis
.

Evolution

It is hard to find a common origin for gonads, but gonads most likely

evolved independently several times.[3]

Regulation

The gonads are controlled by

anterior pituitary gland.[4] This secretion is regulated by gonadotropin-releasing hormone (GnRH) produced in the hypothalamus.[5][6]

Development

The gonads develop from three sources; the mesothelium, underlying mesenchyme and the primordial germ cells. Gonads start developing as a common primordium (an organ in the earliest stage of development), in the form of

development of the urinary and reproductive organs
.

Disease

The gonads are subject to many diseases, such as

agonadism, tumors, and cancer, among others.[citation needed
]

Aging

Ovarian aging

A delay in having children is common in the developed world and this delay is often associated with ovarian infertility and subfertility. Ovarian aging is characterized by progressive decline of the quality and number of oocytes.[9] This decline is likely due, in part, to reduced expression of genes that encode proteins necessary for DNA repair and meiosis.[10][11] Such reduced expression can lead to increased DNA damage and errors in meiotic recombination.[9]

Testicular aging

The testes of older men often have sperm abnormalities that can ultimately lead to infertility.[12] These abnormalities include accumulation of DNA damage and decreased DNA repair ability.[12] During spermatogenesis in the testis, spontaneous new mutations arise and tend to accumulate with age.[13]

See also

References

  1. ^ "the definition of sex gland". Dictionary.com. Archived from the original on 22 July 2015. Retrieved 8 May 2018.
  2. ^ "gonad (noun) American English definition and synonyms - Macmillan Dictionary". www.macmillandictionary.com. Archived from the original on 8 May 2018. Retrieved 8 May 2018.
  3. .
  4. ^ "gonadotropin". The Free Dictionary. Mosby's Medical Dictionary, 8th edition. Elsevier. 2009. Retrieved 4 June 2012.
  5. ^ John W. Kimball (12 February 2011). "Hormones of the Hypothalamus: Gonadotropin-releasing hormone (GnRH)". Kimball's Biology Pages. John W. Kimball (The Saylor Foundation). Archived from the original on 27 June 2012. Retrieved 4 June 2012.
  6. .
  7. ISBN 9781455706846.{{cite book}}: CS1 maint: location missing publisher (link
    )
  8. ^ "Human Developmental Genetics". Institut Pasteur. Archived from the original on 5 May 2012. Retrieved 4 June 2012.
  9. ^ a b Park SU, Walsh L, Berkowitz KM. Mechanisms of ovarian aging. Reproduction. 2021 Jul 14;162(2):R19-R33. doi: 10.1530/REP-21-0022. PMID: 33999842; PMCID: PMC9354567
  10. ^ Yang Q, Mumusoglu S, Qin Y, Sun Y, Hsueh AJ. A kaleidoscopic view of ovarian genes associated with premature ovarian insufficiency and senescence. FASEB J. 2021 Aug;35(8):e21753. doi: 10.1096/fj.202100756R. PMID: 34233068
  11. ^ Turan V, Oktay K. BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging. Hum Reprod Update. 2020 Jan 1;26(1):43-57. doi: 10.1093/humupd/dmz043. PMID: 31822904; PMCID: PMC6935693
  12. ^ a b Dong S, Chen C, Zhang J, Gao Y, Zeng X, Zhang X. Testicular aging, male fertility and beyond. Front Endocrinol (Lausanne). 2022 Oct 13;13:1012119. doi: 10.3389/fendo.2022.1012119. PMID: 36313743; PMCID: PMC9606211
  13. ^ Cioppi F, Casamonti E, Krausz C. Age-Dependent De Novo Mutations During Spermatogenesis and Their Consequences. Adv Exp Med Biol. 2019;1166:29-46. doi: 10.1007/978-3-030-21664-1_2. PMID: 31301044
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