Glycoprotein 130
(Redirected from
Gp130
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| Location (UCSC) | Chr 5: 55.94 – 55.99 Mb | Chr 13: 112.6 – 112.65 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Glycoprotein 130 (also known as gp130, IL6ST, IL6R-beta or CD130) is a
Characteristics
The members of the
G-CSF-R
.
Loss of gp130
gp130 is an important part of many different types of signaling complexes. Inactivation of gp130 is lethal to mice..
Signal transduction
gp130 has no intrinsic
MAPK
signaling.
Interactions
Glycoprotein 130 has been shown to
interact
with:
- Grb2,[11]
- HER2/neu,[12]
- Janus kinase 1[13][14][15]
- Leukemia inhibitory factor receptor,[16][17]
- PTPN11,[13][18][19]
- SHC1,[20]
- SOCS3,[18] and
- TLE1.[21]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000134352 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021756 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 30852638.
- PMID 9501088.
- PMID 8511589.
- PMID 7632928.
- PMID 8552649.
- S2CID 31924790.
- S2CID 32632406.
- S2CID 19754641.
- ^ PMID 9388212.
- PMID 11468294.
- PMID 11742534.
- PMID 12047380.
- PMID 8999038.
- ^ PMID 12403768.
- PMID 10946280.
- S2CID 44339682.
- S2CID 8270300.
Further reading
- Ip NY, Nye SH, Boulton TG, Davis S, Taga T, Li Y, Birren SJ, Yasukawa K, Kishimoto T, Anderson DJ (1992). "CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130". Cell. 69 (7): 1121–32. S2CID 45816061.
- Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T (1991). "Molecular cloning and expression of an IL-6 signal transducer, gp130". Cell. 63 (6): 1149–57. S2CID 30852638.
- Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, Hirano T, Kishimoto T (1989). "Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130". Cell. 58 (3): 573–81. S2CID 41245022.
- Rodriguez C, Grosgeorge J, Nguyen VC, Gaudray P, Theillet C (1995). "Human gp130 transducer chain gene (IL6ST) is localized to chromosome band 5q11 and possesses a pseudogene on chromosome band 17p11". Cytogenet. Cell Genet. 70 (1–2): 64–7. PMID 7736792.
- Narazaki M, Yasukawa K, Saito T, Ohsugi Y, Fukui H, Koishihara Y, Yancopoulos GD, Taga T, Kishimoto T (1993). "Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130". Blood. 82 (4): 1120–6. PMID 8353278.
- Davis S, Aldrich TH, Stahl N, Pan L, Taga T, Kishimoto T, Ip NY, Yancopoulos GD (1993). "LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor". Science. 260 (5115): 1805–8. PMID 8390097.
- Murakami M, Hibi M, Nakagawa N, Nakagawa T, Yasukawa K, Yamanishi K, Taga T, Kishimoto T (1993). "IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase". Science. 260 (5115): 1808–10. PMID 8511589.
- Sharkey AM, Dellow K, Blayney M, Macnamee M, Charnock-Jones S, Smith SK (1996). "Stage-specific expression of cytokine and receptor messenger ribonucleic acids in human preimplantation embryos". Biol. Reprod. 53 (4): 974–81. PMID 8547494.
- Mosley B, De Imus C, Friend D, Boiani N, Thoma B, Park LS, Cosman D (1997). "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation". J. Biol. Chem. 271 (51): 32635–43. PMID 8999038.
- Lee IS, Liu Y, Narazaki M, Hibi M, Kishimoto T, Taga T (1997). "Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin-6". FEBS Lett. 401 (2–3): 133–7. S2CID 32632406.
- Auguste P, Guillet C, Fourcin M, Olivier C, Veziers J, Pouplard-Barthelaix A, Gascan H (1997). "Signaling of type II oncostatin M receptor". J. Biol. Chem. 272 (25): 15760–4. PMID 9188471.
- Schiemann WP, Bartoe JL, Nathanson NM (1997). "Box 3-independent signaling mechanisms are involved in leukemia inhibitory factor receptor alpha- and gp130-mediated stimulation of mitogen-activated protein kinase. Evidence for participation of multiple signaling pathways which converge at Ras". J. Biol. Chem. 272 (26): 16631–6. PMID 9195977.
- Diamant M, Rieneck K, Mechti N, Zhang XG, Svenson M, Bendtzen K, Klein B (1997). "Cloning and expression of an alternatively spliced mRNA encoding a soluble form of the human interleukin-6 signal transducer gp130". FEBS Lett. 412 (2): 379–84. S2CID 12420499.
- Koshelnick Y, Ehart M, Hufnagl P, Heinrich PC, Binder BR (1997). "Urokinase receptor is associated with the components of the JAK1/STAT1 signaling pathway and leads to activation of this pathway upon receptor clustering in the human kidney epithelial tumor cell line TCL-598". J. Biol. Chem. 272 (45): 28563–7. PMID 9353320.
- Kim H, Baumann H (1998). "Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells". J. Biol. Chem. 272 (49): 30741–7. PMID 9388212.
- Bravo J, Staunton D, Heath JK, Jones EY (1998). "Crystal structure of a cytokine-binding region of gp130". EMBO J. 17 (6): 1665–74. PMID 9501088.
- Barton VA, Hudson KR, Heath JK (1999). "Identification of three distinct receptor binding sites of murine interleukin-11". J. Biol. Chem. 274 (9): 5755–61. PMID 10026196.
- Hirota H, Chen J, Betz UA, Rajewsky K, Gu Y, Ross J, Müller W, Chien KR (1999). "Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress". Cell. 97 (2): 189–98. S2CID 17955799.
- Tacken I, Dahmen H, Boisteau O, Minvielle S, Jacques Y, Grötzinger J, Küster A, Horsten U, Blanc C, Montero-Julian FA, Heinrich PC, Müller-Newen G (1999). "Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis". Eur. J. Biochem. 265 (2): 645–55. PMID 10504396.
- Chung TD, Yu JJ, Kong TA, Spiotto MT, Lin JM (2000). "Interleukin-6 activates phosphatidylinositol-3 kinase, which inhibits apoptosis in human prostate cancer cell lines". Prostate. 42 (1): 1–7. S2CID 86404104.
External links
- Cytokine+Receptor+gp130 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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