Graham-Little syndrome
| Graham-Little syndrome | |
|---|---|
| Other names | Graham Little-Piccardi-Lassueur syndrome |
| Specialty | Dermatology  |
Graham-Little syndrome or Graham Little-Piccardi-Lassueur syndrome is a cutaneous condition characterized by
Graham-Little syndrome is more common in women than men and usually presents between the ages 30-70.
Signs and symptoms
Graham-Little syndrome is defined by a follicular spinous papule on the body, scalp, or both, noncicatricial
Causes
Although the precise cause of the condition is unknown, as it is thought to be a variation of
Diagnosis
According to histopathology, early lesions of lichen planopilaris exhibit vacuolar alterations in the outer root sheath as well as perifollicular lymphocytic infiltrates at the level of the isthmus and infundibulum. In more advanced cases, there is epithelial atrophy and perifollicular fibrosis at the level of the isthmus and infundibulum, which results in the distinctive hourglass shape. In more advanced cases, the lost hair follicles are replaced with elastic fibers arranged vertically in place of the lost hair follicles.[3]
Treatment
Epidemiology
Graham-Little syndrome occurs in people between the ages of 30 and 70, with four times as many reports of females experiencing it as males.[3]
See also
- List of cutaneous conditions
References
- ISBN 0-07-138076-0.
- ISBN 978-1416062578. Retrieved October 26, 2019.
- ^ PMC 3129120.
- ISSN 0926-9959.
- ISSN 0001-5555.)
{{cite journal}}: CS1 maint: multiple names: authors list (link - ISSN 1018-8665.
Further reading
- Celen, Arda; Lo Sicco, Kristen; Lee, Nayoung; Meehan, Shane; Weed, Jason (2023-02-01). "Graham-Little-Piccardi-Lasseur Syndrome: A Case Report". Journal of Drugs in Dermatology. 22 (2): 210–216. .
- László, Fekete Gyula (2013-03-14). "Graham‐Little–Piccardi–Lasseur syndrome: case report and review of the syndrome in men". International Journal of Dermatology. 53 (8). Wiley: 1019–1022. ISSN 0011-9059.