Graham reaction
In
anionic additive to the reaction, is retained as a substituent on the diazirine product. The reaction was first reported in 1965.[1] Various reaction mechanisms have been proposed.[2][3]
Amidine substrates for the reaction can easily be formed from the corresponding nitriles via the Pinner reaction. The halide substituent in the diazirine product can be displaced by a various nucleophiles.[4]
References
- ISSN 0002-7863.
- ^ Rzepa, Henry (February 18, 2019). "The Graham reaction: Deciding upon a reasonable mechanism and curly arrow representation".
- .
- PMID 16618094.
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