Granulocyte colony-stimulating factor receptor

Source: Wikipedia, the free encyclopedia.
CSF3R
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_000760
NM_156038
NM_156039
NM_172313

NM_001252651
NM_007782

RefSeq (protein)

NP_000751
NP_724781
NP_758519

NP_001239580
NP_031808

Location (UCSC)Chr 1: 36.47 – 36.48 MbChr 4: 125.92 – 125.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a

macrophages
.

The G-CSF-R is a

Lyn, STAT, and Erk1/2
.

Isoforms

The class IV isoform defective for both internalization and differentiation signaling,[7] and colony-stimulating.

Clinical significance

Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia.[8]

Mutations in the intracellular part of this receptor are also associated with certain types of leukemia.[9]

In clinical medicine, there is a suggestion that use of GCSF should be avoided, at least in children and adolescents and perhaps adults, when G-CSFR isoform IV is overexpressed.[10]

Interactions

Granulocyte colony-stimulating factor receptor has been shown to

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119535 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028859 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. PMID 1371413
    .
  6. ^ "Entrez Gene: CSF3R colony stimulating factor 3 receptor (granulocyte)".
  7. PMID 24170028
    .
  8. .
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  11. ^ .
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Further reading

External links