Guanabenz

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(Redirected from
Guanabenz acetate
)
Guanabenz
Clinical data
Trade namesWytensin
AHFS/Drugs.comConsumer Drug Information
MedlinePlusa686003
ATC code
  • none
Pharmacokinetic data
Protein binding90%
Elimination half-life6 hours
Identifiers
  • 2-(2,6-dichlorobenzylidene)hydrazinecarboximidamide
JSmol)
  • Clc1cccc(Cl)c1\C=N\N=C(/N)N
  • InChI=1S/C8H8Cl2N4/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+ checkY
  • Key:WDZVGELJXXEGPV-YIXHJXPBSA-N checkY
  (verify)

Guanabenz (pronounced GWAHN-a-benz, sold under the trade name Wytensin) is an

antihypertensive drug used in the treatment of high blood pressure (hypertension).[1][2]

The most common side effects during guanabenz therapy are

dry mouth, headache and weakness.[3]

Guanabenz can make one drowsy or less alert, therefore driving or operating dangerous machinery is not recommended.

Research

Guanabenz also has some anti-inflammatory properties in different pathological situations, including multiple sclerosis.[4]

Guanabenz was found in one study to exert an inhibitory effect by decreasing the abundance of the enzyme CH25H, a cholesterol hydroxylase linked to antiviral immunity. Therefore, it is suggested that the drug and similar compounds could be used to treat type I interferon-dependent pathologies and that the CH25H enzyme could be a therapeutic target to control these diseases,[5] including amyotrophic lateral sclerosis.

See also

References

  1. S2CID 2139809.[permanent dead link
    ]
  2. PMID 6599714.[permanent dead link
    ]
  3. ^ "Guanabenz | The Merck Index Online". www.rsc.org. Retrieved 2023-04-17.
  4. PMID 25766071
    .
  5. S2CID 13680678
    .
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