HDAC1
Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.[5]
Function
eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.[6]
Interactions
HDAC1 has been shown to
interact
with:
- Androgen receptor,[7]
- BCL6,[8][9]
- BUB1B,[12]
- BUB1,[12]
- BUB3,[12]
- CBFA2T3,[13][14]
- CDC20,[12]
- CDH1,[12]
- CHD3,[15][16]
- CHD4,[15][17][18]
- COUP-TFII,[19]
- CTBP1,[20][21][22]
- DDX17,[23]
- DDX5,[23]
- DNMT3A,[24]
- DNMT3L,[25][26]
- Death-associated protein 6,[27]
- EED,[28]
- EZH2,[28]
- FKBP3,[31]
- GATA1,[32]
- HMG20B,[33]
- HSPA4,[34]
- HUS1,[35]
- Histone deacetylase 2,[15][17][28][33][34][36][37][38][39][40][41][42][43]
- Homeobox protein TGIF1,[20][44]
- Host cell factor C1,[45]
- IFRD1,[46]
- IKZF1,[47][48]
- ING1,[16][49]
- MBD3,[41][50][51]
- MIER1,[52]
- MLL,[53]
- MTA1,[17][54]
- MTA2,[17][41][55][56]
- Mad1,[12]
- Mdm2,[57]
- Methyl-CpG-binding domain protein 2,[41][58][59]
- Mothers against decapentaplegic homolog 2,[60]
- MyoD,[61][62]
- NFKB1,[63]
- Nuclear receptor co-repressor 2,[36][64]
- P21,[65]
- PCNA,[66]
- PHF21A,[33][67]
- Prohibitin,[68][69]
- Promyelocytic leukemia protein,[70][71]
- RAD9A,[35]
- RBBP4,[17][18][41][42][43][55][58][72][73][74][75]
- RBBP7,[17][41][43][58]
- RCOR1,[33][55]
- RELA,[40][63][76]
- RFC1,[77]
- Retinoblastoma protein,[61][69][78][79][80][81][82]
- Retinoblastoma-like protein 1,[78][79]
- Retinoblastoma-like protein 2,[78][83]
- SAP30,[16][41][84][85][86][87]
- SATB1,[56]
- SIN3A,[15][16][17][18][41][42][55][56][72][73][88][89][90][91]
- SIN3B,[41][47]
- SPEN,[92]
- SUDS3,[88][93]
- SUV39H1,[94]
- TOP2A,[98][99]
- TOP2B,[98][99] and
- Zinc finger and BTB domain-containing protein 16.[8][100][101]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000116478 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028800 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 25717734.
- ^ "Entrez Gene: HDAC1 histone deacetylase 1".
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Further reading
- Wolffe AP (April 1996). "Histone deacetylase: a regulator of transcription". Science. 272 (5260): 371–2. S2CID 27257723.
- Ahringer J (August 2000). "NuRD and SIN3 histone deacetylase complexes in development". Trends in Genetics. 16 (8): 351–6. PMID 10904264.
- Verdin E, Dequiedt F, Kasler HG (May 2003). "Class II histone deacetylases: versatile regulators". Trends in Genetics. 19 (5): 286–93. PMID 12711221.
- Zhang Y, Dufau ML (June 2003). "Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes". The Journal of Steroid Biochemistry and Molecular Biology. 85 (2–5): 401–14. S2CID 28512341.
- Stevens M, De Clercq E, Balzarini J (September 2006). "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention". Medicinal Research Reviews. 26 (5): 595–625. PMID 16838299.
- Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R (June 1995). "E2F-5, a new E2F family member that interacts with p130 in vivo". Molecular and Cellular Biology. 15 (6): 3082–9. PMID 7760804.
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Margolis DM, Somasundaran M, Green MR (February 1994). "Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production". Journal of Virology. 68 (2): 905–10. PMID 8289393.
- Furukawa Y, Kawakami T, Sudo K, Inazawa J, Matsumine A, Akiyama T, Nakamura Y (1996). "Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae". Cytogenetics and Cell Genetics. 73 (1–2): 130–3. PMID 8646880.
- Hassig CA, Fleischer TC, Billin AN, Schreiber SL, Ayer DE (May 1997). "Histone deacetylase activity is required for full transcriptional repression by mSin3A". Cell. 89 (3): 341–7. S2CID 14233219.
- Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN (May 1997). "Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression". Cell. 89 (3): 349–56. S2CID 13490886.
- Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell. 89 (3): 357–64. PMID 9150135.
- Romerio F, Gabriel MN, Margolis DM (December 1997). "Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF". Journal of Virology. 71 (12): 9375–82. PMID 9371597.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Brehm A, Miska EA, McCance DJ, Reid JL, Bannister AJ, Kouzarides T (February 1998). "Retinoblastoma protein recruits histone deacetylase to repress transcription". Nature. 391 (6667): 597–601. S2CID 4326464.
- Magnaghi-Jaulin L, Groisman R, Naguibneva I, Robin P, Lorain S, Le Villain JP, Troalen F, Trouche D, Harel-Bellan A (February 1998). "Retinoblastoma protein represses transcription by recruiting a histone deacetylase". Nature. 391 (6667): 601–5. S2CID 4315457.
- Lin RJ, Nagy L, Inoue S, Shao W, Miller WH, Evans RM (February 1998). "Role of the histone deacetylase complex in acute promyelocytic leukaemia". Nature. 391 (6669): 811–4. S2CID 4383951.
- Luo RX, Postigo AA, Dean DC (February 1998). "Rb interacts with histone deacetylase to repress transcription". Cell. 92 (4): 463–73. S2CID 18857544.
External links
- HDAC1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
