HMG-box
HMG (high mobility group) box | |||||||||||
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In molecular biology, the HMG-box (high mobility group box) is a protein domain which is involved in DNA binding.[1] The domain is composed of approximately 75 amino acid residues that collectively mediate the DNA-binding of chromatin-associated high-mobility group proteins. HMG-boxes are present in many transcription factors and chromatin-remodeling complexes, where they can mediate non-sequence or sequence-specific DNA binding.[2]
Structure
The structure of the HMG-box domain contains three alpha helices separated by loops (see figure to the right).[3]
Function
HMG-box containing proteins only bind non-
transcription, replication, and DNA repair, all of which require changing the conformation of chromatin.[3]
The single and the double box HMG proteins alter DNA architecture by inducing bends upon binding.[4][5]
References
- ^ S2CID 28156847.
- . Retrieved 18 February 2023.
- ^ PMID 11497996.
- ^ D. Murugesapillai et al, DNA bridging and looping by HMO1 provides a mechanism for stabilizing nucleosome-free chromatin, Nucleic Acids Res (2014) 42 (14): 8996-9004
- ^ D. Murugesapillai et al, Single-molecule studies of high-mobility group B architectural DNA bending proteins, Biophys Rev (2016) doi:10.1007/s12551-016-0236-4
External links
- HMG-Box Domains at the U.S. National Library of Medicine Medical Subject Headings (MeSH)