HOXA5
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| Location (UCSC) | Chr 7: 27.14 – 27.14 Mb | Chr 6: 52.18 – 52.18 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Homeobox protein Hox-A5 is a protein that in humans is encoded by the HOXA5 gene.[5][6][7]
Function
In vertebrates, the genes encoding the class of
tumorigenesis.[7]
HoxA5 is controlled, at least in part, by
Comparison of the HoxA5
promoter methylation profile across cell types from the least differentiated (human embryonic stem cells) to the most endothelial-like (human umbilical vein endothelial cells, or HUVECs) shows that the HoxA5 promoter is normally heavily methylated in non-differentiated cells and becomes demethylated as cells differentiate down the endothelial lineage.[14] HoxA5 contains a C-Amp Response Elements (CRE) in its promoter.[8] POL2 and CTCF binding are enriched at the CpG-dense HoxA5 promoter in HUVECs, demonstrating transcriptional activity.[14]
Clinical significance
HoxA5 is suppressed in
DNMT inhibitor decitabine (5Aza) is used to treat this disease. While HoxA5 is known to be hypermethylated in AML, it has not yet been shown whether decitabine directly targets these genes for demethylation.[15][16] HOXA5 has also been nominated as an oncogene in glioblastoma. [17]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000106004 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038253 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1973146.
- S2CID 13370372.
- ^ a b "Entrez Gene: HOXA5 homeobox A5".
- ^ PMID 25953647.
- PMID 19262140.
- PMID 19458547.
- PMID 15757903.
- PMID 21664342.
- PMID 17957028.
- ^ PMID 25979369.
- PMID 16861263.
- PMID 20890077.
- PMID 29632085.
External links
- HOXA5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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