HOXA7
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| Location (UCSC) | Chr 7: 27.15 – 27.16 Mb | Chr 6: 52.19 – 52.2 Mb | |||||||
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Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.[5][6][7]
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.[7]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000122592 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038236 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1973146.
- S2CID 13370372.
- ^ a b "Entrez Gene: HOXA7 homeobox A7".
Further reading
- Balling R, Mutter G, Gruss P, Kessel M (1989). "Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice". Cell. 58 (2): 337–47. S2CID 43658121.
- Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. PMID 2574852.
- Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. PMID 2576652.
- Verlinsky Y, Morozov G, Gindilis V, et al. (1995). "Homeobox gene expression in human oocytes and preembryos". Mol. Reprod. Dev. 41 (2): 127–32. S2CID 43123886.
- Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. PMID 8646877.
- Knoepfler PS, Calvo KR, Chen H, et al. (1998). "Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14553–8. PMID 9405651.
- Min W, Woo HJ, Lee CS, et al. (1998). "307-bp fragment in HOXA7 upstream sequence is sufficient for anterior boundary formation". DNA Cell Biol. 17 (3): 293–9. PMID 9539109.
- McIlhatton MA, Bremner P, McMullin MF, et al. (1998). "Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1". Biochim. Biophys. Acta. 1442 (2–3): 329–33. PMID 9804983.
- Sanger Centre T, Washington University Genome Sequencing Cente T (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. PMID 9847074.
- Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
- Kim MH, Jin H, Seol EY, et al. (2000). "Sequence analysis and tissue specific expression of human HOXA7". Mol. Biotechnol. 14 (1): 19–24. S2CID 25333474.
- La Celle PT, Polakowska RR (2001). "Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation". J. Biol. Chem. 276 (35): 32844–53. PMID 11435435.
- Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. PMID 11857506.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. PMID 12690205.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. PMID 12853948.
- Bertrand FE, Spengeman JD, Shah N, LeBien TW (2004). "B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expression". Leukemia. 17 (12): 2454–9. PMID 14562113.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039.
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External links
- HOXA7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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