HOXC10

Homeobox protein Hox-C10 is a protein that in humans is encoded by the HOXC10 gene.^[5][6]

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation.^[6]

Pathology

• HOXC10 is
  MLL3 and MLL4.^[7]
• Methylation of the estrogen-repressed gene HOXC10 in breast cancer determines resistance to
  epigenetic reprogramming of HOXC10 is observed in endocrine-resistant breast cancer.^[8]

Further reading

• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–402.
  PMID 2574852
  .
• Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (Dec 1986). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proceedings of the National Academy of Sciences of the United States of America. 83 (23): 9104–8.
  PMID 2878432
  .
• Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics. 73 (1–2): 114–5.
  PMID 8646877
  .
• Flagiello D, Gibaud A, Dutrillaux B, Poupon MF, Malfoy B (Oct 1997). "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines". FEBS Letters. 415 (3): 263–7.
  S2CID 26075369
  .
• de Stanchina E, Gabellini D, Norio P, Giacca M, Peverali FA, Riva S, Falaschi A, Biamonti G (Jun 2000). "Selection of homeotic proteins for binding to a human DNA replication origin". Journal of Molecular Biology. 299 (3): 667–80.
  PMID 10835276
  .
• Sandrock B, Egly JM (Sep 2001). "A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH". The Journal of Biological Chemistry. 276 (38): 35328–33.
  PMID 11445587
  .
• Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (Feb 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62.
  PMID 11857506
  .
• Gabellini D, Colaluca IN, Vodermaier HC, Biamonti G, Giacca M, Falaschi A, Riva S, Peverali FA (Jul 2003). "Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression". The EMBO Journal. 22 (14): 3715–24.
  PMID 12853486
  .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J,
  S2CID 4427026
  .
• Zhai Y, Kuick R, Nan B, Ota I, Weiss SJ, Trimble CL, Fearon ER, Cho KR (Nov 2007). "Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion". Cancer Research. 67 (21): 10163–72.
  PMID 17974957
  .

External links

• HOXC10+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.