HOXC8

Source: Wikipedia, the free encyclopedia.
HOXC8
Identifiers
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_022658

NM_010466

RefSeq (protein)

NP_073149

NP_034596

Location (UCSC)Chr 12: 54.01 – 54.01 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene.[4][5][6]

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders.[6] HOXC8 was found to have activity in promoting nerve growth and its expression is dysregulated in patients with neurofibromatosis type 1.[7]

See also

Interactions

HOXC8 has been shown to

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000037965 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. PMID 1973146
    .
  5. .
  6. ^ a b "Entrez Gene: HOXC8 homeobox C8".
  7. PMID 24213587
    .
  8. .
  9. .

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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