HOXD10

Source: Wikipedia, the free encyclopedia.
HOXD10
Identifiers
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_002148

NM_013554

RefSeq (protein)

NP_002139

NP_038582

Location (UCSC)Chr 2: 176.11 – 176.12 MbChr 2: 74.52 – 74.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene.[5]

Function

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development.

Clinical significance

Mutations in this gene have been associated with

Charcot-Marie-Tooth disease.[5][citation needed
]

Regulation

The HOXD10 gene is

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128710 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050368 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: HOXD10 homeobox D10".
  6. PMID 19461655
    .
  7. .
  8. .

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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