HSD3B1

Source: Wikipedia, the free encyclopedia.
HSD3B1
Identifiers
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_000862
NM_001328615

NM_013821

RefSeq (protein)

NP_000853
NP_001315544

NP_038849

Location (UCSC)Chr 1: 119.51 – 119.52 MbChr 3: 98.71 – 98.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

HSD3B1 is a human

3beta-hydroxysteroid dehydrogenase/delta(5)-delta(4)isomerase type I or hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1.[5] While it can carry out the same function as HSD3B2, it localizes primarily to different tissues, such as the placenta and nonsteroidogenic tissues. Its requirement for the production of progesterone
by the placenta, which has a vital role in pregnancy, may be one reason why no disease based on mutations in this gene has been identified to date, besides prostate cancer.

Clinical significance

The 1245C allele encodes for a missense and hyperactive enzyme that increases extragonadal androgen synthesis and is associated with poorer outcomes after androgen deprivation therapy in prostate cancer.[6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000203857 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027869 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: HSD3B1 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1".
  6. PMID 27979506
    .
  7. .

[1]

Further reading


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