Hamster polyomavirus

Source: Wikipedia, the free encyclopedia.
Mesocricetus auratus polyomavirus 1
Virus classification Edit this classification
(unranked): Virus
Realm: Monodnaviria
Kingdom: Shotokuvirae
Phylum: Cossaviricota
Class: Papovaviricetes
Order: Sepolyvirales
Family: Polyomaviridae
Genus: Alphapolyomavirus
Species:
Mesocricetus auratus polyomavirus 1

Hamster polyomavirus (abbreviated HaPyV or HaPV,

Syrian hamsters (Mesocricetus auratus).[3][4]

Genome and taxonomy

The organization of the HaPyV

HaPyV and MPyV are closely genetically related; until recently, they were the only two members of the polyomavirus family known to express the

Structure

Following the typical pattern for polyomaviruses, the HaPyV

icosahedral structure. However, the HaPyV capsid differs from its close relative MPyV and from another well-studied polyomavirus, SV40, in having a T=7 levo rather than dextro symmetry.[9]

Infection and clinical manifestations

Hamster polyomavirus was originally identified in hamster

hematopoietic tumors is unusual for polyomaviruses[1][3] and may be associated with the properties of the HaPyV middle tumor antigen.[11]

HaPyV has primarily been reported in research colonies; it appeared apparently spontaneously in the colony from which it was first described and in which it became enzootic.[3] It was also identified in a 2001 case report as naturally occurring in a pet Syrian hamster.[12] It is shed in urine and this is believed to be the mechanism for transmission, similar to what is observed in mouse polyomavirus. While many known hamster viruses are clinically inapparent, HaPyV (along with hamster parvovirus) is unusual in causing clinically significant disease.[1] The virulence of HaPyV in Syrian hamsters may be due to cross-species transmission from the European hamster, most likely the natural host.[10]

Notes

  1. ^ This was the historically common abbreviation; however, it is ambiguous because it is also used for hamster parvovirus.

References