Haplogroup JT

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Haplogroup JT (mtDNA)
)
Haplogroup JT
Possible time of origin50,300 YBP
Possible place of origin
R2'JT
DescendantsJ, T
Defining mutations11251, 15452A, 16126[1]

Haplogroup JT is a human mitochondrial DNA (mtDNA) haplogroup.

Origin

Haplogroup JT is descended from the macro-haplogroup R. It is the ancestral clade to the mitochondrial haplogroups J and T.

Distribution

JT (predominantly

Etruscans.[2] The root level haplogroup JT* has been assigned to an ancient person found at the Colfiorito necropolis in Umbria in central Italy.[3]

The haplogroup has also been found among

Epipaleolithic at the Taforalt prehistoric site.[4] One ancient individual carried a haplotype, which correlates with either the JT clade or the haplogroup H subclade H14b1 (1/9; 11%).[5]

Subclades

Tree

This phylogenetic tree of haplogroup JT subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation[1] and subsequent published research.

  • R2'JT

Health

Maternally inherited ancient mtDNA variants have clear impact on the presentation of disease in a modern society. Superhaplogroup JT is an example of reduced risk of Parkinson's disease[6] And mitochondrial and mtDNa alterations continue to be promising disease biomarkers.[7][8]

See also

Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups

 
L
) 		   
L0 L1–6  
L1
L2
  
L3
    
L4
L5
L6
M N  
CZ
 D E G Q   O A S R   I
W
 X
Y
C Z B F
R0
   pre-JT   P  
U
HV
JT
 K
H V J T

References

  1. ^
    PMID 18853457
    .
  2. ^ "We Are Not Our Ancestors".
  3. ^ GenBank Accession number: MN687309.1
  4. PMID 24885141
    .
  5. S2CID 4490910
    .
  6. ^ Marom S, Friger M, Mishmar D. MtDNA meta-analysis reveals both phenotype specificity and allele heterogeneity: a model for differential association. Sci Rep. 2017 Feb 23;7:43449. doi: 10.1038/srep43449. PMID 28230165; PMCID: PMC5322532.
  7. ^ Rebeca Martín-Jiménez, Olivier Lurette, and Etienne Hebert-Chatelain.DNA and Cell Biology.Aug 2020.1421-1430.http://doi.org/10.1089/dna.2020.5398
  8. ^ Mitochondrion. 2019 May; 46: 307–312.doi: 10.1016/j.mito.2018.07.008

External links


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