Heartland bandavirus

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Heartland virus
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Heartland bandavirus
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum:
Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Phenuiviridae
Genus: Bandavirus
Species:
Heartland bandavirus
Synonyms[1]
  • Heartland virus
  • Heartland banyangvirus

Heartland bandavirus, sometimes called Heartland virus (HRTV), is a tick-borne

antibody titers against the virus. By 2023 over 50 human infections were reported in at least eleven states.[2][3]

History

The Heartland virus (HRTV) was discovered in 2009 in northwestern Missouri by Dr. Scott Folk of Heartland Regional Medical Center in St. Joseph, Missouri.[4] The virus was first proven to infect humans in June 2009 when two farmers, living 60 miles (97 km) apart, presented with fever, fatigue, diarrhea, thrombocytopenia, and leukopenia.[5] The

Lone Star Tick
transmits the virus to people when feeding on blood.

Classification

The Heartland virus is part of the

viruses which contain 3 segments of −ssRNA. The genus of the virus is Bandavirus and the species is the Heartland virus.[6]

Transmission

In 2013, researchers from the CDC and Missouri Western State University first isolated the Heartland virus (HRTV) from the Lone Star Tick (Amblyomma americanum).[6][7] As of 2013 work continued to identify the

reservoir host,[6]
as HRTV has not been isolated from any wild or domestic animals though many white-tailed deer and raccoon from northwestern Missouri had antibodies to HRTV, suggesting that they may be hosts.

In a 2015 retrospective study using convenience samples of different wild animal sera deer, raccoon, coyotes, and moose had antibodies against HRTV. They lived in thirteen states: Florida, Georgia, Illinois, Indiana, Kansas, Kentucky, Missouri, North Carolina, Tennessee, Texas, but also New Hampshire, Maine and Vermont. The infections could have occurred as early as 2003, based on the estimated ages of affected deer. Since the Lone Star tick does not occur in northern New England it is assumed that a second type of tick can carry HRTV.[8]

Infection

Signs and symptoms

Signs and symptoms include fever in excess of 100.4 °F (38 °C), lethargy (weakness), headaches, muscle pain (

transaminases may also be present.[9]

Risk factors

All known human cases have been reported from five U.S. states: Arkansas, Indiana, Missouri, Oklahoma, and Tennessee. Most people infected were spending time outdoors in regions where ticks are

endemic. Most infections are diagnosed between May and September. People usually report having been bitten by a tick within two weeks prior to seeking health care.[citation needed
]

Diagnosis

Diagnosis is through the elimination of other causes of infectious diseases with related symptoms like

Antibody titers against the virus may also be used to indicate infection with the Heartland virus.[10]

Treatment

Treatment is non-specific. Antibiotics are not useful against viruses.

Intravenous fluid administration and medications for the relief of pain are currently the best options.[11]

Prevention

When planning to spend time outdoors in areas where the virus is known or suspected to be harbored by ticks, it is recommended that one cover the body completely with long sleeves and pants, and to avoid bushy and wooded areas. Although ticks are not consistently repelled by DEET-containing repellents, insect repellents should still be applied to one's body and gear. It is recommended that one perform thorough tick checks after being outside, and to remove any tick immediately. If a tick is found, one should remove the tick by the head, preferably with a pair of fine-tipped tweezers. Squeezing the abdomen of a tick while it is attached can force viruses and bacteria into the wound, increasing the chance of infection. Crushing an unattached tick will also release bacteria and viruses from its abdomen, which may then be able to enter a wound or burrow through the skin.[citation needed]

Human cases

More than 20 human infections have been reported in the United States,[12] but given the obscurity of the disease, the true number of cases is suspected to be substantially larger.

Heartland virus cases
Year Location Deaths Cases
2009 Northwestern Missouri 0 2
2012–2013[10] Missouri, Tennessee[13] 1 6
2014 Missouri,[14] Oklahoma[15] 1 3
2017 Northwestern Arkansas,[12] Indiana [16] 0 3
2023 Maryland/Virginia[17] 1 1

References

  1. ^ Maes, Piet; Kuhn, Jens H. (31 August 2018). "Expansion of the order Bunyavirales" (docx). International Committee on Taxonomy of Viruses (ICTV). Retrieved 20 December 2019. Heartland banyangvirus: derived from Heartland virus (and genus Banyangvirus)
  2. ^ Ed Cara (24 Feb 2023) U.S. Man's Death Suggests Deadly Tick Virus Is Spreading to New Regions
  3. ^ Sichen Liu, et. al. (May 2023) Fatal Case of Heartland Virus Disease Acquired in the Mid-Atlantic Region, United States
  4. ^ Knox, Richard (29 August 2012). "Mysterious New 'Heartland Virus' Discovered in Missouri". Shots: NPR's Health Blog. NPR. Retrieved 2012-08-30.
  5. ^ Grady, Denise (2012-09-03). "New Virus Tied to Ticks Poses Puzzle for Doctors". New York Times. Retrieved 2012-09-07.
  6. ^ a b c Schnirring, Lisa (2013-07-22). "Researchers trace novel Heartland virus to Missouri ticks". CIDRAP. Retrieved 2013-07-23.
  7. PMID 23878186
    .
  8. doi:10.3201/eid2110.150380
  9. PMID 22931317
    .
  10. ^
    PMID 24670929
    .
  11. ^ CDC Media relations CDC Reports More Cases of Heartland Virus Disease CDC press release, 27 March 2014
  12. ^ a b "Case of Heartland virus found in Arkansas resident". Arkansas Department of Health. July 7, 2017. Retrieved July 7, 2017.
  13. doi:10.1093/cid/ciu434
  14. ^ TEDDYE SNELL Taking up arms against Heartland disease, Tahlequah Daily Press, June 18, 2014
  15. ^ Associated Press Rare Heartland virus kills man in Oklahoma CBS News, May 28, 2014
  16. ^ Indiana State Department of Health two cases of Heartland virus confirmed in Indiana, 7/11/2017
  17. PMID 36821867
    .
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