Pro-hevein
(Redirected from
Hevein (protein)
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UniProt P02877 | | ||||||
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Pro-hevein (Alternative name: Major hevein, gene name: HEV1) is a wound-induced[1] and a lectin-like protein from Hevea brasiliensis (rubber tree) where it is involved in the coagulation of latex.[2]
The 187 amino-acid propeptide pro-hevein is cleaved in two fragments: a N-terminal 43 amino-acid Hevein bearing a chitin-binding type-1 domain (also known as
Win-like protein bearing a Barwin domain
.
It has antifungal properties.[3]
Role of hevein in latex allergy
Hevein is the main
allergen cross-reactivity between latex and banana or other fruits like chestnuts or avocadoes.[6] Hevein-like genes can be found in many plants including Arabidopsis thaliana.[7]
Hevein is called Hev b 6 under the WHO allergen nomenclature.[8][9] There are three entries under this classification, corresponding to the conformational epitopes Hev b 6.01, Hev b 6.03, and Hev b 6.03. They correspond to the full Pro-Havein protein, the matur Hevein (N-terminal), and the C-terminal Barwin domain respectively.[10]