History of pharmacy

The history of pharmacy as a modern and independent science dates back to the first third of the 19th century. Before then, pharmacy evolved from antiquity as part of medicine. The history of pharmacy coincides well with the history of medicine, but it's important that there is a distinction between the two topics. Pharmaceuticals is one of the most-researched fields in the academic industry, but the history surrounding that particular topic is sparse compared to the impact its made world-wide. Before the advent of pharmacists, there existed apothecaries that worked alongside priests and physicians in regard to patient care.

Prehistoric pharmacy

Further information: Prehistoric medicine

Paleopharmacological studies attest to the use of medicinal plants in pre-history.

Spirit Cave.^[3]: 8 Prehistoric man learned pharmaceutical techniques through instinct, by watching birds and beasts, and using cool water, leaves, dirt, or mud as a soothing agent.^[4]

Ancient Era

Mesopotamia and Egypt

Sumerian cuneiform tablets record prescriptions for medicine.^[5] Ancient Egyptian pharmacological knowledge was recorded in various papyri, such as the Ebers Papyrus of 1550 BC and the Edwin Smith Papyrus of the 16th century BC.

The very beginnings of pharmaceutical texts were written on clay tablets by Mesopotamians. Some texts included formulas, instructions via pulverization, infusion, boiling, filtering and spreading; herbs were mentioned as well.^[6] Babylon, a state within Mesopotamia, provided the earliest known practice of running an apothecary i.e. pharmacy. Alongside the ill person included a priest, physician, and a pharmacist to tend to their needs.^[4]

Greece

De Materia Medica, Byzantium, 15th century

In Ancient Greece, there existed a separation between physician and herbalist. The duties of the herbalist was to supply physicians with raw materials, including plants, to make medicines.^[7] According to Edward Kremers and Glenn Sonnedecker, "before, during and after the time of Hippocrates there was a group of experts in medicinal plants. Probably the most important representative of these rhizotomoi was Diocles of Carystus (4th century BC). He is considered to be the source for all Greek pharmacotherapeutic treatises between the time of Theophrastus and Dioscorides."^[8]

Between 60 and 78 AD,[3]^: 21–22 the Greek physician Pedanius Dioscorides wrote a five-volume book, De materia medica, covering over 600 plants and coining the term materia medica. It formed the basis for many medieval texts, and was built upon by many Middle Eastern scientists during the Islamic Golden Age.^{[3]: 21–22}

Asia

The earliest known Chinese manual on

The earliest known compilation of medicinal substances in Indian traditional medicine dates to the third or fourth century AD (attributed to Sushruta, who is recorded as a physician of the sixth century BC).

There is a stone sign for a pharmacy with a tripod, a mortar, and a pestle opposite one for a doctor in the Arcadian Way in Ephesus, Turkey.^{[citation needed]}

In Japan, at the end of the Asuka period (538–710) and the early Nara period (710–794), the men who fulfilled roles similar to those of modern pharmacists were highly respected. The place of pharmacists in society was expressly defined in the Taihō Code (701) and re-stated in the Yōrō Code (718). Ranked positions in the pre-Heian Imperial court were established; and this organizational structure remained largely intact until the Meiji Restoration (1868). In this highly stable hierarchy, the pharmacists—and even pharmacist assistants—were assigned status superior to all others in health-related fields such as physicians and acupuncturists. In the Imperial household, the pharmacist was even ranked above the two personal physicians of the Emperor.^[10]

Middle Ages

Middle East

In Baghdad the first pharmacies, or drug stores, were established in 754,^[11] under the Abbasid Caliphate during the Islamic Golden Age. By the ninth century, these pharmacies were state-regulated.^[12]

The advances made in the Middle East in

After the fifth century fall of the Western Roman Empire, medicinal knowledge in Europe suffered due to the loss of Greek medicinal texts and a strict adherence to tradition, although an area of Southern Italy near Salerno remained under Byzantine control and developed a hospital and medical school, which became famous by the 11th century.^[3]: 30

In the early 11th century, Salerno scholar Constantinos Africanus translated many Arabic books into Latin, driving a shift from Hippocratic medicine towards a pharmaceutical-driven approach advocated by Galen.^[3]: 30 In medieval Europe, monks typically did not speak Greek, leaving only Latin texts such as the works of Pliny available until these translations by Constantinos.^[3]: 30 In addition, Arabic medicine became more widely known due to Muslim Spain.^[3]: 30

In the 15th century, the printing press spread medicinal textbooks and formularies; the Antidotarium was the first printed drug formulary.^[3]: 30

In Europe pharmacy-like shops began to appear during the 12th century. In 1240 emperor Frederic II issued a decree by which the physician's and the apothecary's professions were separated.^[14]

Old pharmacies continue to operate in Dubrovnik, Croatia located inside the Franciscan monastery, opened in 1317^{[citation needed]}. The Town Hall Pharmacy in Tallinn, Estonia, which dates back to at least 1422, is the oldest continuously run pharmacy in the world still operating in the original premises.^[15]

The trend towards pharmacy specialization started to take effect in Bruges, Belgium where a new law was passed that forbid physicians to prepare medications for patients.^[7]

The oldest pharmacy is claimed to be set up in 1221 in the Church of Santa Maria Novella in Florence, Italy, which now houses a perfume museum. Florence is also the birthplace of the first official pharmacopeia, called the Nuevo Receptario, in which all pharmacies would use that document as guidance for caring for the sickly.^[4]

The Royal College of Apothecaries of the City and Kingdom of Valencia was founded in 1441, considered the oldest in the world, with full administrative and legislative powers. The apothecaries of Valencia were the first in the world to elaborate their medicines, with the same criteria that are currently required in the official pharmacopoeias.^[16]

The

The 1800s brought increased technical sophistication. By the late 1880s, German dye manufacturers had perfected the purification of individual

Chloral hydrate was introduced as a sleeping aid and sedative in 1869.^[19] Chloroform was first used as an anesthetic in 1847.^[20]

Derivatives of phenothiazines had an important impact on various aspects of medicine, beginning with methylene blue which was originally used as a dye after its synthesis from aniline in 1876.^[21] Phenothiazines were used as antimalarials, antiseptics, and antihelminthics up to 1940.^[22] The "psychopharmacological revolution" began in 1950 when Chlorpromazine was discovered.^[22]

The United States formed the

Frederick Banting and Charles Best found the hormone insulin to lower blood sugar of dogs in 1921. This inspired further work by James Collip who developed pure insulin used for human testing and dramatically changed the prospects for all diabetics.

Alexander Fleming developed the first antibiotic, penicillin, after discovering a fungus that was able to kill off bacteria.^[25]

See also

• International Society for the History of Pharmacy
• British Society for the History of Pharmacy
• History of medicine
• History of pharmacy automation
• History of pharmacy in the United States
• List of drugs by year of discovery
• Museum of the History of Lithuanian Medicine and Pharmacy

References