Hyaline cartilage

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Hyaline cartilage
microanatomy of chondrocytes and organelles, lacunae and matrix.
Identifiers
MeSHD051457
THH2.00.03.5.00015
FMA64783
Anatomical terminology]

Hyaline cartilage is the glass-like (

translucent cartilage found on many joint surfaces. It is also most commonly found in the ribs, nose, larynx, and trachea.[1] Hyaline cartilage is pearl-gray in color, with a firm consistency and has a considerable amount of collagen. It contains no nerves
or blood vessels, and its structure is relatively simple.

Structure

Hyaline cartilage is covered externally by a fibrous membrane known as the perichondrium or, when it's along articulating surfaces, the synovial membrane. This membrane contains vessels that provide the cartilage with nutrition through diffusion.

Hyaline cartilage matrix is primarily made of

chondroitin sulphate, both of which are also found in elastic cartilage
.

Hyaline cartilage exists on the sternal ends of the ribs, in the larynx, trachea, and bronchi, and on the articulating surfaces of bones. It gives the structures a definite but pliable form. The presence of collagen fibres makes such structures and joints strong, but with limited mobility and flexibility.

Hyaline cartilage is the most prevalent type of cartilage. It also forms the temporary embryonic skeleton, which is gradually replaced by bone, and the skeleton of

elasmobranch
fish.

Microanatomy

When a slice of hyaline cartilage is examined under the

homogeneous matrix
. When arranged in groups of two or more, the chondrocytes have rounded, but generally straight outlines; where they are in contact with each other, and in the rest of their circumference, they are rounded.

They consist of translucent protoplasm with fine interlacing filaments and minute granules are sometimes present. Embedded in this are one or two round nuclei, having the usual intranuclear network.

The cells are contained in cavities in the matrix, called

cartilage lacunae. These cavities are actually artificial gaps formed from the shrinking of the cells during the staining and setting of the tissue for examination. The inter-territorial space between the isogenous cell groups contains relatively more collagen fibres, allowing it to maintain its shape while the actual cells shrink, creating the lacunae. This constitutes the so-called 'capsule' of the space. Each lacuna is usually occupied by a single cell, but during mitosis
, it may contain two, four, or even eight cells.

Articular cartilage

Histology of articular cartilage zones.[2]

Articular cartilage is hyaline cartilage on the articular surfaces of bones,[3] and lies inside the joint cavity of synovial joints, bathed in synovial fluid produced by the synovial membrane, which lines the walls of the cavity.

Though it is often found in close contact with

articular disks, articular cartilage is not considered a part of either of these structures, which are made entirely of fibrocartilage
.

The articular cartilage extracellular matrix (ECM) has a highly specialized architecture that is zonally organized: the superficial zone consists mostly of collagen II fibers aligned parallel to the articular surface to resist shear forces, whereas the deep zone consists of the same fibers aligned perpendicularly to the bone interface to absorb compressive loads.[2]

The biochemical breakdown of the articular cartilage results in osteoarthritis – the most common type of joint disease.[4] Osteoarthritis affects over 30 million individuals in the United States alone, and is the leading cause of chronic disability amongst the elderly.[5]

Articular cartilage development begins with interzone condensation of a Collagen II positive limb bud at the future joint site. This is followed by definition of specific cellular subtypes (meniscal progenitors, articular progenitors, synovial progenitors, and ligament progenitors) that will eventually form the joint capsule. Finally, the joint capsule matures and forms a cavity, with a central meniscus, and an encasement of synovium.[6] This final structure will form several distinct layers of the articular cartilage found in all synovial joints including the Deep Zone (closest to the bone), Middle Zone, and Superficial Zone (closest to the synovial fluid).

Maintenance of articular cartilage is guided by a balance of anabolic (cartilage generating)[7][8] and catabolic (cartilage degrading factors),[9][10] in a manner similar to the maintenance of bone.[11] Over the lifetime of the organism, anabolic factors and catabolic factors are generally in balance, however, as the organism ages, catabolism predominates and cartilage begins to degrade. Eventually, the loss of hyaline cartilage matrix and reduction in the chondrocyte content of the hyaline cartilage matrix results in the development of joint disease such as Osteoarthritis (OA). Overexpression of hyaline-cartilage specific anabolic factors, such as FGF18, or appears to restore the balance between cartilage loss and generation.[12][13]

Additional images

  • A synovial joint with bone, articular cartilage, and articular disc shown.
    A synovial joint with bone, articular cartilage, and articular disc shown.
  • Elbow joint. Deep dissection. Anterior view.
    Elbow joint. Deep dissection. Anterior view.

See also

References

  1. ^ Adele, Knibbs (2003). "The Leeds Histology Guide". Retrieved 27 October 2018.
  2. ^
    PMID 27391810
    .
    -"The work is made available under the Creative Commons CC0 public domain dedication."
  3. ^ "Wheeless' Textbook of Orthopaedics". 22 July 2020.
  4. ^ Brown, Angelina. "Coping with Osteoarthritis". Archived from the original on 1 December 2017. Retrieved 24 July 2017.
  5. ^ "Osteoarthritis Fact Sheet". Center for Disease Control and Prevention. Retrieved 24 July 2017.
  6. PMID 32393986
    .
  7. PMID 15781473
    .
  8. PMID 35563063
    .
  9. PMID 14752172
    .
  10. PMID 35883515
    .
  11. PMID 31698687
    .
  12. S2CID 257376179
    .
  13. PMID 15896984
    .

External links

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