Hydromorphone

Source: Wikipedia, the free encyclopedia.
"Dihydromorphinone" redirects here. Not to be confused with dihydromorphine (Paramorfan, etc.), a different opioid.

Hydromorphone
Structural formula of hydromorphone
Space-filling model of hydromorphone
Clinical data
Trade namesDilaudid, Palladone, others
Other namesDihydromorphinone
AHFS/Drugs.comMonograph
MedlinePlusa682013
License data
Pregnancy
category
subcutaneous
Drug classOpioid
ATC code
Legal status
Legal status
Pharmacokinetic data
BioavailabilityBy mouth: 30–35%, Intranasal: 52–58%,[5] IV/IM: 100%
Protein binding20%
MetabolismLiver
Onset of action15 to 30 min[6]
Elimination half-life2–3 hours[7]
Duration of action4 to 5 hrs[6]
ExcretionKidney
Identifiers
  • 4,5-α-Epoxy-3-hydroxy-17-methyl morphinan-6-one
JSmol)
Solubility in waterHCl salt: 333
  • O=C4[C@@H]5Oc1c2c(ccc1O)C[C@H]3N(CC[C@]25[C@H]3CC4)C
  • InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1 checkY
  • Key:WVLOADHCBXTIJK-YNHQPCIGSA-N checkY
  (verify)

Hydromorphone, also known as dihydromorphinone, and sold under the brand name Dilaudid among others, is a

under the skin.[6] Effects generally begin within half an hour and last for up to five hours.[6] A 2016 Cochrane review (updated in 2021) found little difference in benefit between hydromorphone and other opioids for cancer pain.[9]

Common side effects include dizziness, sleepiness, nausea, itchiness, and constipation.

respiratory depression, and serotonin syndrome.[6] Rapidly decreasing the dose may result in opioid withdrawal.[6] Generally, use during pregnancy or breastfeeding is not recommended.[10] Hydromorphone is believed to work by activating opioid receptors, mainly in the brain and spinal cord.[6] Hydromorphone 2 mg IV is equivalent to approximately 10 mg morphine IV.[8]

Hydromorphone was patented in 1923.

generic medication.[6] In 2021, it was the 261st most commonly prescribed medication in the United States, with more than 1 million prescriptions.[14][15]

Side effects

Adverse effects of hydromorphone are similar to those of other potent opioid analgesics, such as

respiratory depression, urinary retention, bronchospasm, and sometimes, circulatory depression.[16] More common side effects include lightheadedness, dizziness, sedation, itching, constipation, nausea, vomiting, headache, perspiration, and hallucinations.[16]
These symptoms are common in ambulatory patients and in those not experiencing severe pain.

Simultaneous use of hydromorphone with other opioids, muscle relaxants, tranquilizers, sedatives, and general anesthetics may cause a significant increase in respiratory depression, progressing to coma or death. Taking benzodiazepines (such as diazepam) in conjunction with hydromorphone may increase side effects such as dizziness and difficulty concentrating.[17] If simultaneous use of these drugs is required, dose adjustment may be made.[18]

A particular problem that may occur with hydromorphone is accidental administration in place of morphine due to a mix-up between the similar names, either at the time the prescription is written or when the drug is dispensed. This has led to several deaths and calls for hydromorphone to be distributed in distinctly different packaging from morphine to avoid confusion.[19][20]

Massive overdoses are rarely observed in opioid-tolerant individuals, but when they occur, they may lead to circulatory system collapse. Symptoms of overdose include respiratory depression, drowsiness leading to coma and sometimes to death, drooping of skeletal muscles, low heart rate, and decreasing blood pressure. At the hospital, individuals with hydromorphone overdose are provided supportive care, such as assisted ventilation to provide oxygen and gut decontamination using activated charcoal through a nasogastric tube. Opioid antagonists, such as naloxone, also may be administered concurrently with oxygen supplementation. Naloxone works by reversing the effects of hydromorphone, and only is administered in the presence of significant respiratory depression and circulatory depression.[18]

Sugar cravings associated with hydromorphone use are the result of a glucose crash after transient hyperglycemia following injection, or a less profound lowering of blood sugar over a period of hours, in common with morphine, heroin, codeine, and other opiates.

Hormone imbalance

Main article: Opioid § Hormone imbalance

As with other opioids, hydromorphone (particularly during heavy chronic use) often causes temporary

hormone imbalance.[21]

Neurotoxicity

In the setting of prolonged use, high dosage, and/or kidney dysfunction, hydromorphone has been associated with neuroexcitatory symptoms such as

cognitive dysfunction.[22][23][24] This toxicity is less than that associated with other classes of opioids such as the pethidine
class of synthetics in particular.

Withdrawal

Users of hydromorphone may experience painful symptoms if the drug is suspended.[25] Some people cannot tolerate the symptoms, which results in continuous drug use.[25] Symptoms of opioid withdrawal are not easy to decipher, as there are differences between drug-seeking behaviors and true withdrawal effects.[26] Symptoms associated with hydromorphone withdrawal include:[25][26][27]

  • Abdominal pain
  • Anxiety or panic attacks
  • Depression
  • Goose bump skin
  • Inability to enjoy daily activities
  • Muscle and joint pain
  • Nausea
  • Runny nose and excessive secretion of tears
  • Sweating
  • Vomiting

In the clinical setting, excessive secretion of tears, yawning, and dilation of pupils are helpful presentations in diagnosing opioid withdrawal.[28] Hydromorphone is a rapid acting pain killer; however, some formulations may last up to several hours. Patients who stop taking this drug abruptly may experience withdrawal symptoms,[27][29] which may start within hours of taking the last dose of hydromorphone, and last up to several weeks.[25] Withdrawal symptoms in people who stopped taking the opioid may be managed by using opioids or non-opioid adjuncts.[30] Methadone is an opioid commonly used for this kind of therapy. However, the selection of therapy should be tailored to each specific person.[31] Methadone also is used for detoxification in people who have opiate addiction, such as heroin or drugs similar to morphine.[31] It may be given orally or intramuscularly. There is controversy regarding whether any opioid (such as methadone) should be included in the treatment of opioid withdrawal symptoms, since these agents also may cause relapse when therapy is suspended.[25] Clonidine is a non-opioid adjunct which may be used in situations where opioid use is not desired, such as in patients with high blood pressure.[32]

Interactions

CNS depressants may enhance the depressant effects of hydromorphone, such as other opioids, anesthetics, sedatives, hypnotics, barbiturates, benzodiazepines, phenothiazines, chloral hydrate, dimenhydrinate, and glutethimide. The depressant effect of hydromorphone also may be enhanced by monoamine oxidase inhibitors (MAO inhibitors), first-generation antihistamines (brompheniramine, promethazine, diphenhydramine, chlorphenamine), beta blockers, and alcohol. When combined therapy is contemplated, the dose of one or both agents should be reduced.[22]

Pharmacology

Hydromorphone at opioid receptors[33]
Ki
Tooltip Inhibitor constant)		 Ratio
MOR
Tooltip μ-Opioid receptor
DOR
Tooltip δ-Opioid receptor
KOR
Tooltip κ-Opioid receptor		 MOR:DOR:KOR
0.47 nM 18.5 nM 24.9 nM 1:39:53

Equianalgesic doses[34][35][36]
Compound Route Dose
Codeine PO 200 mg
Hydrocodone PO 20–30 mg
Hydromorphone PO 7.5 mg
Hydromorphone IV 1.5 mg
Morphine PO 30 mg
Morphine IV 10 mg
Oxycodone PO 20 mg
Oxycodone IV 10 mg
Oxymorphone PO 10 mg
Oxymorphone IV 1 mg

Hydromorphone is a semi-synthetic

euphoria or dysphoria, respiratory depression, cough suppression, decreased gastrointestinal motility, nausea, vomiting, increased cerebrospinal fluid pressure, increased biliary pressure, and increased pinpoint constriction of the pupils.[29]

Formulations

Hydromorphone is available in parenteral, rectal, subcutaneous, and oral formulations, and also can be administered via epidural or intrathecal injection.[37] Hydromorphone also has been administered via nebulization to treat shortness of breath, but it is not used as a route for pain control due to low bioavailability.[38] Transdermal delivery systems are also under consideration to induce local skin analgesia.[39]

Concentrated aqueous solutions of hydromorphone hydrochloride have a visibly different refractive index from pure water, isotonic 9‰ (0·9 per cent) saline and the like, especially when stored in clear ampoules and phials may acquire a slight clear amber discolouration upon exposure to light; this reportedly has no effect on the potency of the solution, but 14-dihydromorphinones such as hydromorphone, oxymorphone, and relatives come with instructions to protect from light.[40] Ampoules of solution which have developed a precipitate should be discarded.[40]

Battery-powered intrathecal drug delivery systems are implanted for chronic pain when other options are ruled out, such as surgery and traditional pharmacotherapy, provided that the patient is considered a suitable fit in terms of any contraindications, both physiological and psychological.[41]

An extended-release (once-daily) version of hydromorphone is available in the United States.[42] Previously, an extended-release version of hydromorphone, Palladone, was available before being voluntarily withdrawn from the market after a July 2005 FDA advisory warned of a high overdose potential when taken with alcohol. As of March 2010, it is still available in the United Kingdom under the brand name Palladone SR, Nepal under the brand name Opidol, and in most other European countries.[43]

Pharmacokinetics

The chemical modification of the morphine molecule to hydromorphone results in higher lipid solubility and greater ability to cross the blood–brain barrier to produce more rapid and complete central nervous system penetration. On a per milligram basis, hydromorphone is considered to be five times as potent as morphine; although the conversion ratio may vary from 4–8 times, five times is in typical clinical usage.[44][45] The development of tolerance also may vary among individuals.

Patients with renal abnormalities must exercise caution when dosing hydromorphone. In those with renal impairment, the half-life of hydromorphone may increase to as much as 40 hours. The typical half-life of intravenous hydromorphone is 2.3 hours.[46] Peak plasma levels usually occur between 30 and 60 minutes after oral dosing.[47]

The onset of action for hydromorphone administered intravenously is less than 5 minutes and within 30 minutes of oral administration (immediate release).[38]

Metabolism

While other opioids in its class, such as codeine or oxycodone, are metabolized via CYP450 enzymes, hydromorphone is not.[48] Hydromorphone is extensively metabolized in the liver to hydromorphone-3-glucuronide, which has no analgesic effects. As similarly seen with the morphine metabolite, morphine-3-glucuronide, a build-up in levels of hydromorphone-3-glucuronide may produce excitatory neurotoxic effects such as restlessness, myoclonus and hyperalgesia. Patients with compromised kidney function and older patients are at higher risk for metabolite accumulation.[49]

Chemistry

With a formula of C17H19NO3 and a molecular weight of 285.343, both identical to morphine, hydromorphone can be considered a structural isomer of morphine and is a hydrogenated ketone thereof.[50]

Hydromorphone is made from morphine either by direct re-arrangement (made by reflux heating of alcoholic or acidic aqueous solution of morphine in the presence of platinum or palladium catalyst) or

potassium tert butoxide or aluminium tert butoxide (Oppenauer oxidation). The 6 ketone group may be replaced with a methylene group via the Wittig reaction to produce 6-Methylenedihydrodesoxymorphine, which is 80× stronger than morphine.[51]

Changing morphine into hydromorphone increases its activity and, therefore, makes hydromorphone approximately eight times stronger than morphine on a weight basis, all other things being equal.[citation needed] Changed also is lipid solubility, contributing to hydromorphone's having a more rapid onset of action and alterations to the overall absorption, distribution, metabolism, and elimination profile as well as the side effect profile (in general, less nausea and itching) versus that of morphine. The semi-synthetic opiates, of which hydromorphone and its codeine analogue hydrocodone are among the best-known and oldest, include a huge number of drugs of varying strengths and with differences among themselves both subtle and stark, allowing for many different options for treatment.

Hydromorphone is more soluble in water than morphine; therefore, hydromorphone solutions may be produced to deliver the drug in a smaller volume of water. The hydrochloride salt is soluble in three parts of water, whereas a gram of morphine hydrochloride dissolves in 16 ml of water; for all common purposes, the pure powder for hospital use can be used to produce solutions of virtually arbitrary concentration. When the powder appeared on the street, this very small volume of powder needed for a dose means that overdoses are likely for those who mistake it for heroin or other powdered narcotics, especially those that have been diluted prior to consumption.[52]

Endogenous production

Hydromorphone is made from morphine via catalytic hydrogenation and also is produced in trace amounts by human and other mammalian metabolisms of morphine. It occasionally appears in assays of opium latex in very small quantities, apparently forming in the plant in an unknown percentage of cases under poorly understood conditions.[citation needed]

Bacteria

Some bacteria have been shown to be able to turn morphine into closely related drugs, including hydromorphone and dihydromorphine among others. The bacterium Pseudomonas putida serotype M10 produces a naturally-occurring NADH-dependent morphinone reductase that can work on unsaturated 7,8 bonds, with result that, when these bacteria are living in an aqueous solution containing morphine, significant amounts of hydromorphone form, as it is an intermediary metabolite in this process; the same goes for codeine being turned into hydrocodone.[53]

The process gave rise to various concentrations of hydromorphone, dihydromorphine, hydromorphinol, and oxymorphone during the experiments. Three paths were found: from morphine to hydromorphone with dihydromorphine as the penultimate step, from morphine to hydromorphone with morphinone as the penultimate step, and from morphine to hydromorphinol to hydromorphone.

History

Hydromorphone was patented in 1923.[11] It was introduced to the mass market in 1926 under the brand name Dilaudid,[54] indicating its derivation and degree of similarity to morphine (by way of laudanum).

Society and culture

Names

Hydromorphone is known in various countries around the world by the brand names Hydal, Dimorphone, Exalgo, Sophidone LP, Dilaudid, Hydrostat, Hydromorfan, Hydromorphan, Hymorphan, Laudicon, Opidol, Palladone, Hydromorph Contin, and others. An extended-release version of hydromorphone, called Palladone, was available for a short time in the United States before being voluntarily withdrawn from the market after a July 2005 FDA advisory warned of a high overdose potential when taken with alcohol.[55] As of March 2010, it is still available in Nepal under the brand name Opidol, in the United Kingdom under the brand name Palladone SR, and in most other European countries.

There has also been a once-daily prolonged release version of hydromorphone available in Australia under the brand name Jurnista as of May 2009.[56]

Legal status

In the United States, the main drug control agency, the Drug Enforcement Administration, reports an increase in annual aggregate production quotas of hydromorphone from 766 kilograms (1,689 pounds) in 1998 to 3,300 kilograms (7,300 lb) in 2006, and an increase in prescriptions in this time of 289%, from about 470,000 to 1,830,000. The 2013 production quota was 5,968 kilograms (13,157 lb).[57]

Like all opioids used for analgesia, hydromorphone is potentially habit-forming and is listed in

ACSCN
for hydromorphone is 9150.

Hydromorphone is listed under the German Betäubungsmittelgesetz as a Betäubungsmittel in the most restricted schedule for medicinal drugs; it is controlled similarly in Austria (Suchtgift) under the SMG and the Swiss BetmG. The Misuse of Drugs Act 1971 (United Kingdom) and comparable French, Canadian, Australian, Italian, Czech, Croatian, Slovenian, Swedish, Polish, Spanish, Greek, Russian, and other laws similarly control it, as do regulations in virtually all other countries.

Use in executions

In 2009, Ohio approved the use of an intramuscular injection of 500 mg of hydromorphone and a supratherapeutic dose of midazolam as a backup means of carrying out executions by lethal injection when a suitable vein cannot be found for intravenous injection.[58]

Hydromorphone and midazolam was injected intravenously to execute double-murderer Joseph Wood in Arizona on 24 July 2014. Wood was heavily sedated (surgical anesthesia) within four minutes from start, but took almost two hours to transition to stage 4 (cessation of respiration) and death.[59]

References

  1. ^ "Hydromorphone Use During Pregnancy". Drugs.com. 19 November 2019. Retrieved 16 May 2020.
  2. ISBN 9781455701506
    .
  3. ISBN 9781455701506. Archived
    from the original on 10 January 2023. Retrieved 20 August 2019.
  4. ^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
  5. S2CID 22694749
    .
  6. ^ a b c d e f g h i j "Hydromorphone Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 15 April 2019.
  7. S2CID 29864565
    .
  8. ^
    ISBN 9780857113382
    .
  9. PMID 34350974
    .
  10. ^ "Hydromorphone Use During Pregnancy". Drugs.com. Retrieved 15 April 2019.
  11. ^
    ISBN 9783527607495
    .
  12. ISBN 9780080462127
    .
  13. hdl:10665/371090
    . WHO/MHP/HPS/EML/2023.02.
  14. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  15. ^ "Hydromorphone - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
  16. ^ a b "Hydromorphone Monograph (Side Effects & Drug Interactions)". RxList Inc. 2008. Archived from the original on 13 February 2008.
  17. ^ "Drug interactions between Dilaudid and Valium". Retrieved 19 November 2014.
  18. ^ a b "Dilaudid (hydromorphone hydrochloride) Oral LiquidDilaudid (hydromorphone hydrochloride) Tablets". app.purduepharma.com. Retrieved 5 November 2015.
  19. PMID 1377371
    .
  20. PMID 16308048
    .
  21. PMID 23414717
    .
  22. ^
    PMID 15353098
    .
  23. S2CID 21782204
    .
  24. PMID 8610865
    .
  25. ^ a b c d e "Hydromorphone / Dilaudid Detox". Rapid Drug Detox. Retrieved 5 November 2015.
  26. ^ a b "Dilaudid Abuse & Addiction Withdrawals, Signs, Symptoms & Effects – Acadiana Addiction Center". www.acadianaaddiction.com. Retrieved 5 November 2015.
  27. ^ a b "Hydromorphone Drug Information". Narconon International. Retrieved 5 November 2015.
  28. ^ McKeown NJ, West PL (13 July 2022). VanDeVoort JT, Burns MJ, Gaeta TJ (eds.). "Withdrawal Syndromes: Practice Essentials, Background, Pathophysiology". Medscape.
  29. ^ a b "DILAUDID® ORAL LIQUID and DILAUDID® TABLETS Package Insert" (PDF). FDA. 2007. Retrieved 5 November 2015.
  30. ^ "Opioid withdrawal protocol" (PDF). www.saskatoonhealthregion.ca. Archived from the original (PDF) on 25 November 2015. Retrieved 5 November 2015.
  31. ^ a b "4 Treatment Protocols". Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction. Treatment Improvement Protocol (TIP) Series. Vol. 40. Rockville (MD): Substance Abuse and Mental Health Services Administration (US). 1 January 2004.
  32. PMID 6131140
    .
  33. PMID 11197347
    .
  34. ISBN 978-1-4496-1073-9
    .
  35. ISBN 978-0-323-11374-8
    .
  36. ISBN 978-0-7295-8162-2
    .
  37. PMID 18488078
    .
  38. ^
    S2CID 22849970
    .
  39. ISSN 1526-5900
    .
  40. ^ a b Dilaudid HP package insert Nov 2004
  41. PMID 17309136
    .
  42. ^ "EXALGO (hydromorphone hydrochloride) extended release tablets Package Insert" (PDF). FDA. 2010. Retrieved 5 November 2015.
  43. ^ "zalicus.com". www.zalicus.com. Retrieved 2 September 2017.
  44. ^ "Opioid Conversion Guidelines" (PDF). alfredhealth.org.au. Archived from the original (PDF) on 4 March 2016. Retrieved 2 September 2017.
  45. ^ "Switching Opioids" (PDF). mcmaster.ca. Retrieved 2 September 2017.
  46. ^ "Hydromorphone". That's Poppycock!. 19 February 2009. Archived from the original on 14 October 2012. Retrieved 5 November 2012.
  47. ^ "Dilaudid Clinical Pharmacology". rxlist.com. Archived from the original on 12 June 2008. Retrieved 2 September 2017.
  48. PMID 24290733
    .
  49. ^ Buck M (July 2008). "Use of Hydromorphone in Children and Adolescents" (PDF). University of Virginia Children's Hospital. Archived from the original (PDF) on 17 February 2014. Retrieved 5 November 2015.
  50. ^ Merck Index 2003, "Morphine" and "Hydromorphone"
  51. ^ PHA 4220 – Neurology Pharmacotherapeutics Archived 16 July 2007 at the Wayback Machine
  52. ^ "Hydromorphone Hydrochloride" (PDF). Stamford, CT: Purdue Pharma L.P. 13 October 2009. MSDS No. 71681. Archived from the original (PDF) on 17 January 2015. Retrieved 5 November 2015.
  53. PMID 7487001
    .
  54. PMID 21841049
    .
  55. ^ "Information for Healthcare Professionals: Hydromorphone Hydrochloride Extended-Release Capsules (marketed as Palladone)". Center for Drug Evaluation and Research. 15 July 2005. Retrieved 16 August 2016.
  56. ^ "Hydromorphone prolonged-release tablets (Jurnista) for chronic severe disabling pain". NPS Medicinewise. May 2009. Retrieved 7 December 2020.
  57. ^ "Proposed Adjustments to the Aggregate Production Quotas for Schedule I and II Controlled Substances and Assessment of Annual Needs for the List I Chemicals Ephedrine, Pseudoephedrine, and Phenylpropanolamine for 2013". Drug Enforcement Administration (DEA), Department of Justice. 20 June 2014. Archived from the original on 14 May 2017. Retrieved 26 July 2014.
  58. ^ "Ohio Prisons Director Announces Changes to Ohio's Execution Process". Ohio Department of Rehabilitation and Correction. 13 November 2009. Archived from the original on 15 January 2013. Retrieved 17 January 2014.
  59. ^ "Arizona execution takes two hours". BBC News. 24 July 2014. Retrieved 24 July 2014.

External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=Hydromorphone&oldid=1211746754"