Hydroxyethyl starch
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Trade names | Hespan, Voluven, Volulyte, Tetrahes, Hestar | |
Routes of administration | Intravenous | |
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Hydroxyethyl starch (HES/HAES), sold under the brand name Voluven among others, is a nonionic starch derivative, used as a volume expander in intravenous therapy. The use of HES on critically ill patients is associated with an increased risk of death and kidney problems.[2][3]
HES is a general term and can be sub-classified according to average molecular weight, molar substitution, concentration, C2/C6 ratio and Maximum Daily Dose.[4] The European Medicines Agency commenced in June 2013 the process of agreeing to reduced indications which was completed in October 2013.[5] The process of full withdrawal in the EU was expected to complete in 2018.
Medical uses
An intravenous solution of hydroxyethyl starch is used to prevent
Adverse effects
HES can cause anaphylactoid reactions: hypersensitivity, mild influenza-like symptoms,
HES derivatives have been demonstrated to have increased rates of
During 2010/11 a large number of research papers associated with Joachim Boldt were retracted for ethical reasons, and this may affect clinical guidelines referring to HES preparations prepared before this date.[11] In 2013 a meta-analysis on HES in critically ill patients showed that only the Boldt studies showed an improvement with HES; all other studies showed significant risks with no benefits.[12]
Contraindications
Prescribing information contains the following contraindications:
- This product should not be used in people who are hypersensitive or allergic to hydroxyethyl starch.
- Patients with kidney failure not related to low blood volume and patients on dialysis should avoid this product in high doses which are used for volume expansion.
- Use of hydroxyethyl starch with normal saline in its preparation is contraindicated in people with severe increases in blood levels of sodium or chloride.
- Patients with intracranial bleeds should not use this product.
On November 25, 2013, following a public workshop to discuss new information on the risks and benefits of HES solution,[13] the USFDA announced the addition of a black box warning to the prescribing information which includes the following recommendations to health professionals:[14]
- Do not use HES solutions in critically ill adult patients, including those with sepsis.
- Avoid use in patients with pre-existing renal dysfunction.
- Discontinue use of HES at the first sign of renal injury.
- Need for renal replacement therapy has been reported up to 90 days after HES administration. Continue to monitor renal function for at least 90 days in all patients.
- Avoid use in patients undergoing open heart surgery in association with cardiopulmonary bypass due to excess bleeding.
- Discontinue use of HES at the first sign of coagulopathy.
- Do not use HES products in patients with severe liver disease
- Monitor liver function in patients receiving HES products.
Safety concerns
High molecular weight HES has been linked to
In June 2012 a 6S paper was published in the
The CHEST study compared Hes130/0.40 with Saline in 7000 patients. The study was performed in patients that were less sick than in 6s; however, the increase in mortality was similar to 6s. There has also been a significant increase in dialysis rate overall. The increase in creatinine confirmed the pathophysiological rationale. Furthermore, the patients needed more blood products, had significant more liver failure and itching. The study was published in the NEJM in October 2012.[18]
As a consequence, in November 2012 the European Regulatory Agency (EMA) started an Official Procedure to Assess the Safety of all HES Products. The FDA in September 2012 conducted a Public Workshop addressing Safety concerns of HES,[13] which according to the majority of participants should be addressed by regulators. The Surviving Sepsis Campaign decided to ban HES from treatment in sepsis patients. [19]
On June 14, 2013, PRAC, which is the safety committee of EMA, the European regulatory agency, published on their official website the recommendation to suspend the marketing authorisation of all HES products in Europe. The risk benefit ratio is negative based on results of 3 megatrials (VISEP, 6S, CHEST). A clinical benefit could not be demonstrated in any patient population, and there was ample evidence of harm, especially kidney failure due to long-term storage of the product in vital organs severely restricting its potential indications.[5] The FDA followed on June 24. MHRA recalled the HES products on June 27 as the risks outweigh potential benefits and safer and cheaper alternatives are available.[14][20] In July 2021 the FDA further restricted the label of HES in the US. Due to side effects also in the patients in the operating room the product should only be used, when no other fluid for volume replacement therapy is available. This restricts HES use to the battle field as an example.[21] Due to this negative label the two largest HES producers deregistered their global HES brands in the US.[22][23]
The EMA held an ad hoc expert meeting on December 18, 2017, to help inform its further consideration of the issue. Some further longer term data had been published although some trials had yet to complete. On January 12, 2018, PRAC [Pharamocovigilance Risk Assessment Committee] recommended the European Medicine Agency to withdraw the marketing authorization of hydroxyethyl starch containing medicinal products. An issue was that some use appeared to be outside the restricted license, potentially in areas of practice where there was evidence of harm. This may be a global issue as there is evidence that in areas of practice such as post-partum hemorrhage use has continued outside WHO guidelines. The recommendation was adopted by the Mutual Recognition and Decentralized Procedure Co-ordination Group (CMDh) on January 26, 2018.[24] In April 2018, the European Commission requested that the PRAC and the CMDh further consider any possible unmet medical need that could result from a suspension, as well as the feasibility and likely effectiveness of additional risk minimisation measures. After looking at these specific aspects, in May 2018 the PRAC confirmed its previous recommendation for suspension and sent a revised recommendation to the CMDh. The CMDh concluded that HES solutions for infusion should remain on the market provided that a combination of additional measures to protect patients is implemented. The European Commission took an EU-wide legally binding decision on 17 July 2018.[25] On May 22, 2022 EMS banned HES in the EU. In 2018 implemented measures of controlled access to hospitals and training of users did not stop the use in ICU/sepsis patients .to prevent harm from these patients of a drug with no demonstrated clinical benefit, the registrations of all HES in EU are suspended.[26]
Pharmacokinetics
Different types of hydroxyethyl starches are typically described by their average molecular weight, typically around 130 to 200 kDa (bearing in mind that there will be a range of different-sized molecules in any given solution); and their degree of molar substitution (what proportion of the glucose units on the starch molecule have been modified with hydroxyethyl units), typically around 0.35 to 0.5. A solution of hydroxyethyl starch may further be described by its concentration in % (i.e. grams per 100ml). So for example, one commercially available hydroxyethyl starch (Voluven) is described as 6% HES 130 / 0.4.
The elimination depends on molar substitution degree. Molecules smaller than the renal threshold (60–70 kDa) are readily excreted in the urine while a small part of the larger ones are metabolized by plasma α–amylase before those degradation products are renally excreted. However HES is only partly degraded and excreted, while for a large amount the metabolism remains unclear. Approximately one-third to two-thirds of administered HES cannot be accounted for by 24-h urinary excretion. In one study the cumulative excretion over 72 h was 50% of the administered dose. HES has remained detectable in plasma 4 months after infusion, and in skin tissue up to 54 months after HES infusion. Administered HES accumulates in large quantities within diverse tissues where it can persist for periods of several years.[27] Therefore, HES should not be administered for longer than 24 hours.[28]
See also
References
- FDA. Retrieved 22 October 2023.
- ^ PMID 23423413.
- ISBN 0-19-261239-5.
- ^ PMID 19512862.
- ^ a b "Hydroxyethyl-starch solutions (HES) should no longer be used in patients with sepsis or burn injuries or in critically ill patients" (Press release). European Medicines Agency. 23 October 2013.
- PMID 30073665.
- ISBN 978-0-443-06618-4.
- S2CID 8441982.
- ^ PMID 21269526.
- PMID 19226441.
- ^ [dead link] Editors-in-Chief Statement Regarding Published Clinical Trials Conducted without IRB Approval by Joachim Boldt (PDF), 4 March 2011, archived from the original (PDF) on 21 March 2011
- PMID 23423420.
- ^ a b "Public Workshop: Risks and Benefits of Hydroxyethyl Starch Solutions", Vaccines, Blood & Biologics, U.S. Food and Drug Administration
- ^ a b "FDA Safety Communication: Boxed Warning on increased mortality and severe renal injury, and additional warning on risk of bleeding, for use of hydroxyethyl starch solutions in some settings", Vaccines, Blood & Biologics, U.S. Food and Drug Administration, 25 November 2013
- ^ S2CID 7973629.
- ^ S2CID 5893988.
- ^ a b Wojcik J (24 July 2012). "Pharma giant threatens Danish scientist". ScienceNordic. Retrieved 13 August 2012.
- PMID 23075127.
- S2CID 34855187.
- ^ Press release: MHRA suspends use of hydroxyethyl starch (HES) drips, Medicines and Healthcare products Regulatory Agency, 27 June 2013, archived from the original on 1 July 2013
- ^ "Labeling Changes on mortality, kidney injury, and excess bleeding with hydroxyethyl starch products". FDA. October 2021. Retrieved 22 February 2023.
- ^ "Federal Register". FDA. 9 December 2021. Retrieved 22 February 2023.
- ^ "Federal Register". FDA. 22 September 2021. Retrieved 22 February 2023.
- ^ "European Medicines Agency - Human medicines - Hydroxyethyl starch (HES) containing medicinal products". www.ema.europa.eu. Retrieved 27 January 2018.
- ^ "Hydroxyethyl starch solutions: CMDh introduces new measures to protect patients". European Medicines Agency. 17 July 2018.
- ^ "Hydroxyethyl-starch solutions for infusion recommended for suspension from the market | European Medicines Agency". 24 February 2022. Retrieved 11 June 2022.
- S2CID 13483776.
- ^ "PRAC confirms that hydroxyethyl-starch solutions (HES) should no longer be used in patients with sepsis or burn injuries or in critically ill patients" (Press release). Pharmacovigilance Risk Assessment Committee, European Medicines Agency. 11 October 2013.
Further reading
- Mishler IV JM (February 1984). "Synthetic plasma volume expanders--their pharmacology, safety and clinical efficacy". Clinics in Haematology. 13 (1): 75–92. PMID 6202449.
External links
- Information on Hespan
- FDA press release approving Voluven at the Wayback Machine (archived December 28, 2007)