ID1
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| Location (UCSC) | Chr 20: 31.61 – 31.61 Mb | Chr 2: 152.58 – 152.58 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
DNA-binding protein inhibitor ID-1 is a protein that in humans is encoded by the ID1 gene.[5][6]
Function
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the
basic HLH family of transcription factors.[5] The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts.[5] This protein may play a role in cell growth, senescence, and differentiation.[7][8][9] Two transcript variants encoding different isoforms have been found for this gene.[10]
Interactions
ID1 has been shown to
interact weakly with MyoD[5][11][12][13][14][15][16] but very tightly with ubiquitously expressed E proteins.[17] E proteins heterodimerize with tissue restricted bHLH proteins such as Myod, NeuroD, etc. to form active transcription complexes so by sequestering E proteins, Id proteins can inhibit tissue restricted gene expression in multiple cell lineages using the same biochemical mechanism. Other interacting partners include CASK.[18]
Clinical significance
ID1 can be used to mark endothelial progenitor cells which are critical to tumor growth and angiogenesis.[19][20] Targeting ID1 results in decreased tumor growth.[21][22] ID1 has been shown to be targeted by cannabidiol in certain gliomas and breast cancers.[23][24]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000125968 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042745 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ S2CID 29514374.
- PMID 8294468.
- PMID 12888293.
- S2CID 19850793.
- PMID 28794185.
- ^ "Entrez Gene: ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein".
- S2CID 4427531.
- PMID 9242638.
- PMID 8380166.
- PMID 9528857.
- PMID 12145280.
- PMID 18674781.
- PMID 1644289.
- PMID 15694377.
- S2CID 4396535.
- S2CID 12961562.
- S2CID 205273623.
- PMID 20807818.
- PMC 8168201.
- S2CID 2192838.
Further reading
- Zhu W, Dahmen J, Bulfone A, Rigolet M, Hernandez MC, Kuo WL, et al. (June 1995). "Id gene expression during development and molecular cloning of the human Id-1 gene". Brain Research. Molecular Brain Research. 30 (2): 312–26. PMID 7637581.
- Deed RW, Jasiok M, Norton JD (September 1994). "Nucleotide sequence of the cDNA encoding human helix-loop-helix Id-1 protein: identification of functionally conserved residues common to Id proteins". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1219 (1): 160–2. PMID 8086456.
- Mathew S, Chen W, Murty VV, Benezra R, Chaganti RS (November 1995). "Chromosomal assignment of human ID1 and ID2 genes". Genomics. 30 (2): 385–7. PMID 8586447.
- Nehlin JO, Hara E, Kuo WL, Collins C, Campisi J (February 1997). "Genomic organization, sequence, and chromosomal localization of the human helix-loop-helix Id1 gene". Biochemical and Biophysical Research Communications. 231 (3): 628–34. PMID 9070860.
- Anand G, Yin X, Shahidi AK, Grove L, Prochownik EV (August 1997). "Novel regulation of the helix-loop-helix protein Id1 by S5a, a subunit of the 26 S proteasome". The Journal of Biological Chemistry. 272 (31): 19140–51. PMID 9235903.
- Langlands K, Yin X, Anand G, Prochownik EV (August 1997). "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". The Journal of Biological Chemistry. 272 (32): 19785–93. PMID 9242638.
- Yates PR, Atherton GT, Deed RW, Norton JD, Sharrocks AD (February 1999). "Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors". The EMBO Journal. 18 (4): 968–76. PMID 10022839.
- Outinen PA, Sood SK, Pfeifer SI, Pamidi S, Podor TJ, Li J, et al. (August 1999). "Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells". Blood. 94 (3): 959–67. PMID 10419887.
- Langlands K, Down GA, Kealey T (November 2000). "Id proteins are dynamically expressed in normal epidermis and dysregulated in squamous cell carcinoma". Cancer Research. 60 (21): 5929–33. PMID 11085505.
- Ohtani N, Zebedee Z, Huot TJ, Stinson JA, Sugimoto M, Ohashi Y, et al. (February 2001). "Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence". Nature. 409 (6823): 1067–70. S2CID 4352931.
- Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, et al. (October 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. PMID 11591653.
- Korchynskyi O, ten Dijke P (February 2002). "Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter". The Journal of Biological Chemistry. 277 (7): 4883–91. PMID 11729207.
- Jögi A, Persson P, Grynfeld A, Påhlman S, Axelson H (March 2002). "Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation". The Journal of Biological Chemistry. 277 (11): 9118–26. PMID 11756408.
- Singh J, Murata K, Itahana Y, Desprez PY (March 2002). "Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex". Oncogene. 21 (12): 1812–22. PMID 11896613.
- Liu CJ, Ding B, Wang H, Lengyel P (May 2002). "The MyoD-inducible p204 protein overcomes the inhibition of myoblast differentiation by Id proteins". Molecular and Cellular Biology. 22 (9): 2893–905. PMID 11940648.
- Ouyang XS, Wang X, Ling MT, Wong HL, Tsao SW, Wong YC (May 2002). "Id-1 stimulates serum independent prostate cancer cell proliferation through inactivation of p16(INK4a)/pRB pathway". Carcinogenesis. 23 (5): 721–5. PMID 12016143.
- Ling MT, Wang X, Tsao SW, Wong YC (April 2002). "Down-regulation of Id-1 expression is associated with TGF beta 1-induced growth arrest in prostate epithelial cells". Biochimica et Biophysica Acta (BBA) - General Subjects. 1570 (3): 145–52. PMID 12020803.
- Wang X, Xu K, Ling MT, Wong YC, Feng HC, Nicholls J, Tsao SW (September 2002). "Evidence of increased Id-1 expression and its role in cell proliferation in nasopharyngeal carcinoma cells". Molecular Carcinogenesis. 35 (1): 42–9. S2CID 33701077.
External links
- ID1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: P20067 (Mouse DNA-binding protein inhibitor ID-1) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.