ID3 (gene)
DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the ID3 gene.[5][6]
Function
Members of the ID family of helix-loop-helix (HLH) proteins lack a basic DNA-binding domain and inhibit transcription through formation of nonfunctional dimers that are incapable of binding to DNA.[supplied by OMIM][6]
Interactions
ID3 (gene) has been shown to
Repressors of ID3
BTG2 binds to the promoter of Id3 and represses its activity. By this mechanism, the upregulation of Id3 in the hippocampus caused by BTG2 ablation prevents terminal differentiation of hippocampal neurons.[9]
See also
References
- ^ a b c ENSG00000117318 GRCh38: Ensembl release 89: ENSG00000283060, ENSG00000117318 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007872 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1628620.
- ^ a b "Entrez Gene: ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein".
- PMID 9525934.
- PMID 9242638.
- PMID 20020054.
Further reading
- White PS, Maris JM, Beltinger C, Sulman E, Marshall HN, Fujimori M, Kaufman BA, Biegel JA, Allen C, Hilliard C, Valentine MB, Look AT, Enomoto H, Sakiyama S, Brodeur GM (1995). "A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3". Proc. Natl. Acad. Sci. U.S.A. 92 (12): 5520–4. PMID 7777541.
- Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T (1994). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. PMID 7821789.
- Deed RW, Hirose T, Mitchell EL, Santibanez-Koref MF, Norton JD (1994). "Structural organisation and chromosomal mapping of the human Id-3 gene". Gene. 151 (1–2): 309–14. PMID 7828896.
- Deed RW, Bianchi SM, Atherton GT, Johnston D, Santibanez-Koref M, Murphy JJ, Norton JD (1993). "An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types". Oncogene. 8 (3): 599–607. PMID 8437843.
- Ishiguro A, Spirin K, Shiohara M, Tobler A, Norton JD, Rigolet M, Shimbo T, Koeffler HP (1995). "Expression of Id2 and Id3 mRNA in human lymphocytes". Leuk. Res. 19 (12): 989–96. PMID 8632670.
- Wibley J, Deed R, Jasiok M, Douglas K, Norton J (1996). "A homology model of the Id-3 helix-loop-helix domain as a basis for structure-function predictions". Biochim. Biophys. Acta. 1294 (2): 138–46. PMID 8645731.
- Loveys DA, Streiff MB, Kato GJ (1996). "E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein". Nucleic Acids Res. 24 (14): 2813–20. PMID 8759016.
- Deed RW, Armitage S, Norton JD (1996). "Nuclear localization and regulation of Id protein through an E protein-mediated chaperone mechanism". J. Biol. Chem. 271 (39): 23603–6. PMID 8798572.
- Deed RW, Jasiok M, Norton JD (1996). "Attenuated function of a variant form of the helix-loop-helix protein, Id-3, generated by an alternative splicing mechanism". FEBS Lett. 393 (1): 113–6. S2CID 27733563.
- Chen B, Lim RW (1997). "Physical and functional interactions between the transcriptional inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism regulating muscle-specific gene expression". J. Biol. Chem. 272 (4): 2459–63. PMID 8999959.
- Langlands K, Yin X, Anand G, Prochownik EV (1997). "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". J. Biol. Chem. 272 (32): 19785–93. PMID 9242638.
- Deed RW, Hara E, Atherton GT, Peters G, Norton JD (1997). "Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation". Mol. Cell. Biol. 17 (12): 6815–21. PMID 9372912.
- Deed RW, Jasiok M, Norton JD (1998). "Lymphoid-specific expression of the Id3 gene in hematopoietic cells. Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukemia cells". J. Biol. Chem. 273 (14): 8278–86. PMID 9525934.
- Asp J, Thornemo M, Inerot S, Lindahl A (1998). "The helix-loop-helix transcription factors Id1 and Id3 have a functional role in control of cell division in human normal and neoplastic chondrocytes". FEBS Lett. 438 (1–2): 85–90. S2CID 22138517.
- Yates PR, Atherton GT, Deed RW, Norton JD, Sharrocks AD (1999). "Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors". EMBO J. 18 (4): 968–76. PMID 10022839.
- Moldes M, Boizard M, Liepvre XL, Fève B, Dugail I, Pairault J (1999). "Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocytes". Biochem. J. 344. 344 Pt 3 (3): 873–80. PMID 10585876.
- Bounpheng MA, Dimas JJ, Dodds SG, Christy BA (1999). "Degradation of Id proteins by the ubiquitin-proteasome pathway". FASEB J. 13 (15): 2257–64. S2CID 12697752.
- Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. PMID 11591653.
- Jögi A, Persson P, Grynfeld A, Påhlman S, Axelson H (2002). "Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation". J. Biol. Chem. 277 (11): 9118–26. PMID 11756408.
External links
- ID3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it. |