IDX-184

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IDX-184
Legal status
Legal status
  • US: Investigational drug
Identifiers
  • S-[2-{[(2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]methoxy-(benzylamino)phosphoryl}oxyethyl] 3-hydroxy-2,2-dimethylpropanethioate
JSmol)
  • C[C@]1([C@@H]([C@H](O[C@H]1N2C=NC3=C2N=C(NC3=O)N)COP(=O)(NCC4=CC=CC=C4)OCCSC(=O)C(C)(C)CO)O)O
  • InChI=1S/C25H35N6O9PS/c1-24(2,13-32)22(35)42-10-9-38-41(37,28-11-15-7-5-4-6-8-15)39-12-16-18(33)25(3,36)21(40-16)31-14-27-17-19(31)29-23(26)30-20(17)34/h4-8,14,16,18,21,32-33,36H,9-13H2,1-3H3,(H,28,37)(H3,26,29,30,34)/t16-,18-,21-,25-,41?/m1/s1
  • Key:FGHMGRXAHIXTBM-TWFJNEQDSA-N

IDX-184 is an

NS5B RNA polymerase inhibitor.[1][2] While it showed reasonable effectiveness in early clinical trials it did not progress past Phase IIb.[3] However research using this drug has continued as it shows potentially useful activity against other emerging viral diseases such as Zika virus,[4][5] and coronaviruses including MERS,[6] and SARS-CoV-2.[7][8]

References

  1. PMID 32214769
    .
  2. S2CID 53501774
    .
  3. S2CID 39936873
    .
  4. S2CID 21846603
    .
  5. S2CID 4811956
    .
  6. PMID 27864902
    .
  7. PMID 32119961
    .
  8. PMID 32222463
    .
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