IFITM1
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| Location (UCSC) | Chr 11: 0.31 – 0.32 Mb | n/a | |||||||
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Interferon-induced transmembrane protein 1 is a protein that in humans is encoded by the IFITM1 gene.[3][4] IFITM1 has also recently been designated CD225 (cluster of differentiation 225). This protein has several additional names: fragilis (human homolog of the mouse protein), IFI17 [interferon-induced protein 17], 9-27 [Interferon-inducible protein 9-27] and Leu13.
IFITM1 is a member of the IFITM family (Interferon-induced transmembrane protein) which is encoded by IFITM genes. The human IFITM genes locate on chromosome 11 and have four members: IFITM1, IFITM2, IFITM3 and IFITM5..
Molecular biology
The IFITM1 gene is located on the Watson (plus) strand of the short arm of chromosome 11 (11p15.5) and is 3,956 bases in length. The encoded protein has 125 amino acids (molecular weight 13.964 kDa).
It is an intrinsic membrane protein and is predicted to cross the membrane several times.
Structure and function
IFITM proteins have a short N-terminal and C-terminal domain, two transmembrane domains (TM1 and TM2) and a short cytoplasmic domain. The first transmembrane domain (TM1) and the cytoplasmic domain are conserved among different IFITM proteins in humans and mice.[6] In the absence of interferon stimulation, IFITM proteins can express broadly in tissues and cell lines. In humans, IFITM1, IFITM2 and IFITM3 are able to express in different tissues and cells while the expression of IFITM5 is limited to osteoblasts.[7] The type I and II interferon induce IFITM proteins expression significantly. IFITM proteins are involved in the physiological process of immune response signaling, germ cell maturation and development.[8]
Biochemistry
The gene is induced by interferon and the protein forms part of the signaling pathway.
Antiviral function of IFITM proteins
IFITM proteins have been identified as cell-autonomous proteins that suppress the early stages of
IFITM proteins also are able to inhibit several infection with other
IFITM proteins inhibit
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000185885 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 7559564.
- ^ "Entrez Gene: IFITM1 interferon induced transmembrane protein 1 (9-27)".
- PMID 22537233.
- PMID 20601941.
- PMID 16326387.
- PMID 1906403.
- ^ PMID 23358889.
- PMID 22046135.
- PMID 20064371.
- PMID 18596815.
- PMID 23601107.
Further reading
- Bradbury LE, Kansas GS, Levy S, et al. (1992). "The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules". J. Immunol. 149 (9): 2841–50. S2CID 23655762.
- Takahashi S, Doss C, Levy S, Levy R (1990). "TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen". J. Immunol. 145 (7): 2207–13. S2CID 30999229.
- Reid LE, Brasnett AH, Gilbert CS, et al. (1989). "A single DNA response element can confer inducibility by both alpha- and gamma-interferons". Proc. Natl. Acad. Sci. U.S.A. 86 (3): 840–4. PMID 2492664.
- Kelly JM, Gilbert CS, Stark GR, Kerr IM (1986). "Differential regulation of interferon-induced mRNAs and c-myc mRNA by alpha- and gamma-interferons". Eur. J. Biochem. 153 (2): 367–71. PMID 3935435.
- Friedman RL, Manly SP, McMahon M, et al. (1984). "Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells". Cell. 38 (3): 745–55. S2CID 37810920.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Kita K, Sugaya S, Zhai L, et al. (2003). "Involvement of LEU13 in interferon-induced refractoriness of human RSa cells to cell killing by X rays". Radiat. Res. 160 (3): 302–8. S2CID 34613110.
- Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. PMID 14667819.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMID 15489334.
- Akyerli CB, Beksac M, Holko M, et al. (2005). "Expression of IFITM1 in chronic myeloid leukemia patients". Leuk. Res. 29 (3): 283–6. S2CID 43389978.
- Yang Y, Lee JH, Kim KY, et al. (2005). "The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells". Cancer Lett. 221 (2): 191–200. PMID 15808405.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. S2CID 4427026.
External links
- IFITM1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.