IFNAR1
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Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene.[5][6]
Function
The protein encoded by this gene is a
Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.[6]
Interactions
IFNAR1 has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000142166 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022967 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 140206806.
- ^ a b "Entrez Gene: IFNAR1 interferon (alpha, beta and omega) receptor 1".
- PMID 9029147.
- PMID 9121453.
- PMID 7559568.
- PMID 8605876.
- PMID 9733772.
- PMID 18474601.
Further reading
- Bürglin TR, Barnes TM (1992). "Introns in sequence tags". Nature. 357 (6377): 367–8. S2CID 2693051.
- Qiujing Yu; Yuliya V Katlinskaya; et al. (2015). "DNA-Damage-Induced Type I Interferon Promotes Senescence and Inhibits Stem Cell Function". Cell Reports. 11 (5): 785–797. PMID 25921537.
- Lutfalla G, Gardiner K, Proudhon D, Vielh E, Uzé G (1992). "The structure of the human interferon alpha/beta receptor gene". J. Biol. Chem. 267 (4): 2802–9. PMID 1370833.
- Flores I, Mariano TM, Pestka S (1991). "Human interferon omega (omega) binds to the alpha/beta receptor". J. Biol. Chem. 266 (30): 19875–7. PMID 1834641.
- Lutfalla G, Roeckel N, Mogensen KE, Mattei MG, Uzé G (1990). "Assignment of the human interferon-alpha receptor gene to chromosome 21q22.1 by in situ hybridization". J. Interferon Res. 10 (5): 515–7. PMID 2148760.
- Uzé G, Lutfalla G, Gresser I (1990). "Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA". Cell. 60 (2): 225–34. S2CID 54409221.
- Colamonici O, Yan H, Domanski P, Handa R, Smalley D, Mullersman J, Witte M, Krishnan K, Krolewski J (1994). "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase". Mol. Cell. Biol. 14 (12): 8133–42. PMID 7526154.
- Uddin S, Chamdin A, Platanias LC (1995). "Interaction of the transcriptional activator Stat-2 with the type I interferon receptor". J. Biol. Chem. 270 (42): 24627–30. PMID 7559568.
- Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, Colamonici OR (1995). "Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling". J. Biol. Chem. 270 (37): 21606–11. PMID 7665574.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Yan H, Krishnan K, Greenlund AC, Gupta S, Lim JT, Schreiber RD, Schindler CW, Krolewski JJ (1996). "Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein". EMBO J. 15 (5): 1064–74. PMID 8605876.
- Yang CH, Shi W, Basu L, Murti A, Constantinescu SN, Blatt L, Croze E, Mullersman JE, Pfeffer LM (1996). "Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor". J. Biol. Chem. 271 (14): 8057–61. PMID 8626489.
- Abramovich C, Yakobson B, Chebath J, Revel M (1997). "A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor". EMBO J. 16 (2): 260–6. PMID 9029147.
- Eantuzzi L, Eid P, Malorni W, Rainaldi G, Gauzzi MC, Pellegrini S, Belardelli F, Gessani S (1997). "Post-translational up-regulation of the cell surface-associated alpha component of the human type I interferon receptor during differentiation of peripheral blood monocytes: role in the biological response to type I interferon". Eur. J. Immunol. 27 (5): 1075–81. S2CID 6569287.
- Gessani S, Borghi P, Fantuzzi L, Varano B, Conti L, Puddu P, Belardelli F (1997). "Induction of cytokines by HIV-1 and its gp120 protein in human peripheral blood monocyte/macrophages and modulation of cytokine response during differentiation". J. Leukoc. Biol. 62 (1): 49–53. S2CID 31546644.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Krishnan K, Singh B, Krolewski JJ (1998). "Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor". J. Biol. Chem. 273 (31): 19495–501. PMID 9677371.
- Richter MF, Duménil G, Uzé G, Fellous M, Pellegrini S (1998). "Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1". J. Biol. Chem. 273 (38): 24723–9. PMID 9733772.
- Rani MR, Leaman DW, Han Y, Leung S, Croze E, Fish EN, Wolfman A, Ransohoff RM (1999). "Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase". J. Biol. Chem. 274 (45): 32507–11. PMID 10542297.
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