IFNAR2
| IFNAR2 | |||
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Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process |
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| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| RefSeq (mRNA) |
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| RefSeq (protein) |
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| Location (UCSC) | Chr 21: 33.21 – 33.27 Mb | Chr 16: 91.17 – 91.2 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Interferon-alpha/beta receptor beta chain is a protein that in humans is encoded by the IFNAR2 gene.[5]
Function
The protein encoded by this gene is a
Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene.[6]
Interactions
IFNAR2 has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000159110 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022971 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 140206806.
- ^ "Entrez Gene: IFNAR2 interferon (alpha, beta and omega) receptor 2".
- ^ PMID 11301323.
- PMID 11046044.
- PMID 10339405.
- ^ PMID 9121453.
- PMID 11786546.
Further reading
- Caraglia M, Marra M, Pelaia G, Maselli R, Caputi M, Marsico SA, Abbruzzese A (2005). "Alpha-interferon and its effects on signal transduction pathways". J. Cell. Physiol. 202 (2): 323–35. S2CID 4833543.
- Raz R, Cheung K, Ling L, Levy DE (1995). "Three distinct loci on human chromosome 21 contribute to interferon-alpha/beta responsiveness". Somat. Cell Mol. Genet. 21 (2): 139–45. S2CID 972314.
- Lutfalla G, Holland SJ, Cinato E, Monneron D, Reboul J, Rogers NC, Smith JM, Stark GR, Gardiner K, Mogensen KE (1995). "Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster". EMBO J. 14 (20): 5100–8. PMID 7588638.
- Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, Colamonici OR (1995). "Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling". J. Biol. Chem. 270 (37): 21606–11. PMID 7665574.
- Novick D, Cohen B, Tal N, Rubinstein M (1995). "Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor". J. Leukoc. Biol. 57 (5): 712–8. S2CID 24680458.
- Platanias LC, Uddin S, Domanski P, Colamonici OR (1996). "Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor". J. Biol. Chem. 271 (39): 23630–3. PMID 8798579.
- Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.
- Croze E, Russell-Harde D, Wagner TC, Pu H, Pfeffer LM, Perez HD (1996). "The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein". J. Biol. Chem. 271 (52): 33165–8. PMID 8969169.
- Li X, Leung S, Kerr IM, Stark GR (1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Mol. Cell. Biol. 17 (4): 2048–56. PMID 9121453.
- Piehler J, Schreiber G (1999). "Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2". J. Mol. Biol. 289 (1): 57–67. PMID 10339405.
- Chuntharapai A, Gibbs V, Lu J, Ow A, Marsters S, Ashkenazi A, De Vos A, Jin Kim K (1999). "Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2". J. Immunol. 163 (2): 766–73. PMID 10395669.
- Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. PMID 10830953.
- Croze E, Usacheva A, Asarnow D, Minshall RD, Perez HD, Colamonici O (2000). "Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor". J. Immunol. 165 (9): 5127–32. PMID 11046044.
- Usacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O (2001). "The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor". J. Biol. Chem. 276 (25): 22948–53. PMID 11301323.
- Nguyen VP, Saleh AZ, Arch AE, Yan H, Piazza F, Kim J, Krolewski JJ (2002). "Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling". J. Biol. Chem. 277 (12): 9713–21. PMID 11786546.
- Chill JH, Nivasch R, Levy R, Albeck S, Schreiber G, Anglister J (2002). "The human interferon receptor: NMR-based modeling, mapping of the IFN-alpha 2 binding site, and observed ligand-induced tightening". Biochemistry. 41 (11): 3575–85. PMID 11888273.
- Velichko S, Wagner TC, Turkson J, Jove R, Croze E (2002). "STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues". J. Biol. Chem. 277 (38): 35635–41. PMID 12105218.
- Usacheva A, Kotenko S, Witte MM, Colamonici OR (2002). "Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors". J. Immunol. 169 (3): 1302–8. PMID 12133952.
- Gauzzi MC, Canini I, Eid P, Belardelli F, Gessani S (2002). "Loss of type I IFN receptors and impaired IFN responsiveness during terminal maturation of monocyte-derived human dendritic cells". J. Immunol. 169 (6): 3038–45. PMID 12218119.
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