IL1RL2
(Redirected from
IL-1Rrp2
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| Location (UCSC) | Chr 2: 102.19 – 102.24 Mb | Chr 1: 40.36 – 40.41 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene.[5][6][7][8]
The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000115598 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070942 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 53171191.
- PMID 10191101.
- PMID 11466363.
- ^ a b "Entrez Gene: IL1RL2 interleukin 1 receptor-like 2".
Further reading
- McMahan CJ, Slack JL, Mosley B, et al. (1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types". EMBO J. 10 (10): 2821–32. PMID 1833184.
- Colotta F, Re F, Muzio M, et al. (1993). "Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4". Science. 261 (5120): 472–5. PMID 8332913.
- Torigoe K, Ushio S, Okura T, et al. (1997). "Purification and characterization of the human interleukin-18 receptor". J. Biol. Chem. 272 (41): 25737–42. PMID 9325300.
- Born TL, Smith DE, Garka KE, et al. (2000). "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling". J. Biol. Chem. 275 (39): 29946–54. PMID 10882729.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Ozkara C, Uzan M, Tanriverdi T, et al. (2006). "Lack of association between IL-1beta/alpha gene polymorphisms and temporal lobe epilepsy with hippocampal sclerosis". Seizure: The Journal of the British Epilepsy Association. 15 (5): 288–91. PMID 16546408.