IL2RB

Source: Wikipedia, the free encyclopedia.
IL2RB
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_000878
NM_001346222
NM_001346223

NM_008368

RefSeq (protein)

NP_000869
NP_001333151
NP_001333152

NP_032394

Location (UCSC)Chr 22: 37.13 – 37.18 MbChr 15: 78.36 – 78.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin-2 receptor subunit beta is a protein that in humans is encoded by the IL2RB gene.[5] Also known as CD122; IL15RB; P70-75.[5]

Function

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind

CD25) and is not involved in signal transduction. The intermediate affinity form consists of a gamma/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.[5]

This protein also forms one of the three subunits of the

IL-15 receptor
.

Activation of the receptor increases proliferation of CD8+ effector T cells.[6]

Interactions

IL2RB has been shown to

interact
with:

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100385 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068227 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c "Entrez Gene: IL2RB interleukin 2 receptor, beta".
  6. S2CID 22680847
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Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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