ILF2

Source: Wikipedia, the free encyclopedia.
ILF2
Available structures
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_004515
NM_001267809

NM_026374

RefSeq (protein)

NP_001254738
NP_004506

NP_080650

Location (UCSC)n/aChr 3: 90.38 – 90.4 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin enhancer-binding factor 2 is a protein that in humans is encoded by the ILF2 gene.[4][5]

Function

Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.[5]

Interactions

ILF2 has been shown to

interact with CDC5L[6] and DNA-PKcs.[7]

ILF2 and ILF3 have been identified as autoantigens in mice with induced lupus,[8][9] in canine systemic rheumatic autoimmune disease,[10][11] and as a rare finding in humans with autoimmune disease.[12]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001016 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. PMID 7519613
    .
  5. ^ a b "Entrez Gene: ILF2 interleukin enhancer binding factor 2, 45kDa".
  6. PMID 11101529
    .
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Further reading

External links


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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