IRF8
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| Location (UCSC) | Chr 16: 85.9 – 85.92 Mb | Chr 8: 121.46 – 121.48 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Interferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a
myeloid cell maturation including the decision for a common myeloid progenitor (CMP) to differentiate into a monocyte
precursor cell.
Function
Interferon Consensus Sequence-binding protein (ICSBP) is a transcription factor of the interferon regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-α and IFN-β. IRF family proteins also control expression of IFN-α and IFN-β-regulated genes that are induced by viral infection.[5]
Knockout studies
IFN-producing cells (mIPCs) were absent in all lymphoid organs from ICSBP
CCR7.[8]
Clinical significance
In myeloid cells, IRF8 regulates the expression of
Bax and Fas to regulate apoptosis.[9] In chronic myelogenous leukemia (CML), IRF8 regulates acid ceramidase to mediate CML apoptosis.[10]
IRF8 is highly expressed in myeloid cells and was originally identified in as a critical lineage-specific transcription factor for myeloid cell differentiation,
Analysis of human cancer genomics database revealed that IRF8 is not significantly focally amplified across the entire dataset of 3131 tumors, but is significantly focally deleted across the entire dataset of 3131 tumors, suggesting that IRF8 is potentially a
suggesting that these cells might use DNA methylation to silence IRF8 expression to advance the disease.Interactions
IRF8 has been shown to
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000140968 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041515 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: IRF8 interferon regulatory factor 8".
- PMID 1460054.[permanent dead link]
- PMID 11997525.
- PMID 11846985.
- PMID 21949018.
- PMID 21487040.
- S2CID 18065448.
- PMID 19155307.
- PMID 17878376.
- ^ PMID 17409439.
- ^ "Tumorscape". The Broad Institute. Archived from the original on 2012-04-14. Retrieved 2012-07-05.
- PMID 19074829.
- PMID 9742224.
- PMID 7768900.
- PMID 10991940.
Illustrations
Further reading
- Weisz A, Marx P, Sharf R, Appella E, Driggers PH, Ozato K, Levi BZ (1993). "Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes". J. Biol. Chem. 267 (35): 25589–96. PMID 1460054.
- Sharf R, Azriel A, Lejbkowicz F, Winograd SS, Ehrlich R, Levi BZ (1995). "Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors". J. Biol. Chem. 270 (22): 13063–9. PMID 7768900.
- Holtschke T, Löhler J, Kanno Y, Fehr T, Giese N, Rosenbauer F, Lou J, Knobeloch KP, Gabriele L, Waring JF, Bachmann MF, Zinkernagel RM, Morse HC, Ozato K, Horak I (1996). "Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene". Cell. 87 (2): 307–17. S2CID 18065448.
- Schaper F, Kirchhoff S, Posern G, Köster M, Oumard A, Sharf R, Levi BZ, Hauser H (1998). "Functional domains of interferon regulatory factor I (IRF-1)". Biochem. J. 335 (1): 147–57. PMID 9742224.
- Li W, Nagineni CN, Ge H, Efiok B, Chepelinsky AB, Egwuagu CE (1999). "Interferon consensus sequence-binding protein is constitutively expressed and differentially regulated in the ocular lens". J. Biol. Chem. 274 (14): 9686–91. PMID 10092656.
- Li W, Nagineni CN, Hooks JJ, Chepelinsky AB, Egwuagu CE (1999). "Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors". Invest. Ophthalmol. Vis. Sci. 40 (5): 976–82. PMID 10102295.
- Rehli M, Poltorak A, Schwarzfischer L, Krause SW, Andreesen R, Beutler B (2000). "PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene". J. Biol. Chem. 275 (13): 9773–81. PMID 10734131.
- Cohen H, Azriel A, Cohen T, Meraro D, Hashmueli S, Bech-Otschir D, Kraft R, Dubiel W, Levi BZ (2001). "Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome". J. Biol. Chem. 275 (50): 39081–9. PMID 10991940.
- Nehyba J, Hrdlicková R, Burnside J, Bose HR (2002). "A novel interferon regulatory factor (IRF), IRF-10, has a unique role in immune defense and is induced by the v-Rel oncoprotein". Mol. Cell. Biol. 22 (11): 3942–57. PMID 11997525.
- Zhu C, Saberwal G, Lu Y, Platanias LC, Eklund EA (2005). "The interferon consensus sequence-binding protein activates transcription of the gene encoding neurofibromin 1". J. Biol. Chem. 279 (49): 50874–85. PMID 15371411.
- Liu J, Guan X, Tamura T, Ozato K, Ma X (2005). "Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein". J. Biol. Chem. 279 (53): 55609–17. PMID 15489234.
- Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. S2CID 39457788.
- Xiong H, Li H, Kong HJ, Chen Y, Zhao J, Xiong S, Huang B, Gu H, Mayer L, Ozato K, Unkeless JC (2005). "Ubiquitin-dependent degradation of interferon regulatory factor-8 mediated by Cbl down-regulates interleukin-12 expression". J. Biol. Chem. 280 (25): 23531–9. PMID 15837792.
- Zhao J, Kong HJ, Li H, Huang B, Yang M, Zhu C, Bogunovic M, Zheng F, Mayer L, Ozato K, Unkeless J, Xiong H (2006). "IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-gamma signaling pathways". J. Biol. Chem. 281 (15): 10073–80. PMID 16484229.
- Huang W, Saberwal G, Horvath E, Zhu C, Lindsey S, Eklund EA (2006). "Leukemia-associated, constitutively active mutants of SHP2 protein tyrosine phosphatase inhibit NF1 transcriptional activation by the interferon consensus sequence binding protein". Mol. Cell. Biol. 26 (17): 6311–32. PMID 16914719.
- Dimberg A, Kårehed K, Nilsson K, Oberg F (2006). "Inhibition of monocytic differentiation by phosphorylation-deficient Stat1 is associated with impaired expression of Stat2, ICSBP/IRF8 and C/EBPepsilon". Scand. J. Immunol. 64 (3): 271–9. S2CID 22527134.
- Leonard D, Svenungsson E, Sandling JK, Berggren O, Jönsen A, Bengtsson C, Wang C, Jensen-Urstad K, Granstam SO, Bengtsson AA, Gustafsson JT, Gunnarsson I, Rantapää-Dahlqvist S, Nordmark G, Eloranta ML, Syvänen AC, Rönnblom L (2013). "Coronary Heart Disease in Systemic Lupus Erythematosus Is Associated with Interferon Regulatory Factor 8 Gene Variants". Circ. Cardiovasc. Genet. 6 (3): 255–63. PMID 23661672.
- Peng YB, Yerle M, Liu B (2007). "Mapping of nine porcine interferon regulatory factor genes". Anim. Genet. 37 (6): 600–1. PMID 17121613.
- Huang W, Horvath E, Eklund EA (2007). "PU.1, interferon regulatory factor (IRF) 2, and the interferon consensus sequence-binding protein (ICSBP/IRF8) cooperate to activate NF1 transcription in differentiating myeloid cells". J. Biol. Chem. 282 (9): 6629–43. PMID 17200120.
- Mattei F, Schiavoni G, Borghi P, Venditti M, Canini I, Sestili P, Pietraforte I, Morse HC, Ramoni C, Belardelli F, Gabriele L (2006). "ICSBP/IRF-8 differentially regulates antigen uptake during dendritic-cell development and affects antigen presentation to CD4+ T cells". Blood. 108 (2): 609–617. PMID 16569763.
- Schiavoni G, Mattei F, Sestili P, Borghi P, Venditti M, Morse HC, Belardelli F, Gabriele L (2002). "ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells". J. Exp. Med. 196 (11): 1415–1425. PMID 12461077.
External links
- IRF8+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.