Integrin alpha 5
(Redirected from
ITGA5
)Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.[5]
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.[6]
Interactions
ITGA5 has been shown to
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000161638 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000555 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 2454952.
- ^ "Entrez Gene: ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)".
- PMID 11479315.
Further reading
- Ruoslahti E (1996). "Integrin signaling and matrix assembly". Tumour Biol. 17 (2): 117–24. PMID 8658014.
- Coulombel L, Auffray I, Gaugler MH, Rosemblatt M (1997). "Expression and function of integrins on hematopoietic progenitor cells". Acta Haematol. 97 (1–2): 13–21. PMID 8980606.
- Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell Biol. 8 (10): 390–6. PMID 9789327.
- Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization". BioEssays. 23 (7): 628–39. S2CID 23712246.
External links
- CD49e+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ITGA5 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
- Overview of all the structural information available in the PDB for UniProt: P08648 (Human Integrin alpha-5) at the PDBe-KB.
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