Integrin alpha 6
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| Location (UCSC) | Chr 2: 172.43 – 172.51 Mb | Chr 2: 71.58 – 71.69 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.
Function
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.[5] Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas.[6]
Interactions
ITGA6 has been shown to
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000091409 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027111 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: ITGA6 integrin, alpha 6".
- PMID 27371534.
- PMID 9360996.
- PMID 11479315.
Further reading
- Lipscomb EA, Mercurio AM (September 2005). "Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression". Cancer and Metastasis Reviews. 24 (3): 413–23. S2CID 26150860.
External links
- CD49f+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ITGA6 Info with links in the Cell Migration Gateway Archived 11 December 2014 at the Wayback Machine
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