Ibogamine
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Ibogamine is an
anti-addictive, CNS stimulant alkaloid found in Tabernanthe iboga and Crepe Jasmine (Tabernaemontana divaricata).[1][2][3] Basic research related to how addiction affects the brain has used this chemical.[4]
Ibogamine persistently reduced the self-administration of cocaine and morphine in rats.[5] The same study found that ibogamine (40 mg/kg) and coronaridine (40 mg/kg) did not produce "any tremor effects in rats that differ significantly from saline control". While the related alkaloids ibogaine (20–40 mg/kg), harmaline (10–40 mg/kg) and desethylcoronaridine (10–40 mg/kg) were "obviously tremorgenic".[5]
Chemistry
Synthesis
Ibogamine can be prepared from one-step demethoxycarbonylation process through coronaridine.[6]
Pharmacology
Like ibogaine, it has seems to have similar pharmacology. It has effects on KOR,[7] NMDAR, nAChR[8] and serotonin sites.[9] It also inhibits acetylcholinesterase and butyrylcholinesterase.[10]