Idiotopes
In
Idiotopes contrast with allotopes, which are non-varying structures on the Fc receptor.[1]
If a separate antibody is produced that has specific binding capabilities to an idiotope of the previously described antibody, it is said to be an "anti-idiotypic antibody". If such is the case, the anti-idiotypic antibodies will be able to bind to the
This type of regulation was proposed by Danish immunologist
Because of the resemblance of anti-idiotypic antibodies to the original antigen, vaccine studies have been performed.[3] These types of vaccines are called "idiotypic vaccines". An anti-idiotypic monoclonal antibody was generated to possess an "internal image of cocaine".[4] The anti-idiotypic antibody bound to the human dopamine transporter with mimicry of the cocaine molecule and completely inhibited cocaine binding.[5] None are produced commercially to date.
References
- ^ a b "Dorlands Medical Dictionary". Retrieved 2008-03-23.
- ^ "How Anti-Idiotypic Antibodies are Essential to Drug Discovery". News & Blogs. GenScript Biotech. January 19, 2018. Retrieved 2021-12-29.
- PMID 23133825.
- PMID 12878327.
- S2CID 23356539.