Ifenprodil
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IUPAC name
4-[2-(4-Benzylpiperidin-1-yl)-1-hydroxypropyl]phenol
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Identifiers | |
3D model (
JSmol ) |
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ChEMBL | |
ChemSpider | |
ECHA InfoCard
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100.041.341 |
IUPHAR/BPS |
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KEGG | |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C21H27NO2 | |
Molar mass | 325.445 |
Pharmacology | |
C04AX28 (WHO) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Ifenprodil is an inhibitor of the NMDA receptor,[1] specifically of GluN1 (glycine-binding NMDA receptor subunit 1) and GluN2B (glutamate-binding NMDA receptor subunit 2) subunits.[2] Additionally, ifenprodil inhibits GIRK channels, and interacts with alpha1 adrenergic, serotonin, and sigma receptors.[3]
NMDA receptors are multimeric
is obligate for functional expression. Other subunits include GluN2A, GluN2B, and the more recently discovered GluN3 subunits. Ifenprodil selectively inhibits NMDA receptors containing the GluN2B subunit.As ifenprodil tartrate, it has been marketed in some countries, including Japan and France, as a cerebral vasodilator, under the trade names Cerocral, Dilvax, and Vadilex.[4]
Ifenprodil has been studied as a possible medication to prevent tinnitus after acoustic trauma.[5]
It is currently in
References
- PMID 2555674.
- S2CID 195681796.
- PMID 16123769.
- ^ The Merck Index (Thirteenth ed.). Whitehouse Station, NJ: Merck Research Laboratories Division of Merck & Co., Inc. 2001. p. 878.
- PMID 18301716.
- ^ "Ifenprodil - Algernon Pharmaceuticals - AdisInsight". adisinsight.springer.com. Retrieved March 25, 2021.