Imolamine
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| Trade names | Angolon, Angoril, Circuline, Irri-Cor, Irrigor, Coremax |
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Imolamine (
Synthesis
Butalamine has very similar synthesis but is alkylated on the alternate nitrogen position.
The reaction of benzoylchloride oxime [698-16-8] (2) with Cyanamide (3) gives 3-Phenyl-1,2,4-oxadiazol-5-amine [3663-37-4] (4). Alkylation with 2-chlorotriethylamine [100-35-6] (5) in the presence of KOH base occurs at the endocyclic ring nitrogen completing the synthesis of imolamine (6).
EFforts towards Onepot method (section 2.5 & 2.6).
References
- ISBN 978-3-88763-075-1.
- ISBN 978-1-4757-2085-3.
- ^ Anne Rolland, EP 0191253 (1986 to Laboratoires Albert Rolland SA).
- ^ Anne Rolland, FR 2576789 (1986 to Laboratoires Albert Rolland SA).
- ^ FR2023M idem J M D Aron-Samuel & J J Sterne, GB 1010231 (1965-11-17).