Impact of health on intelligence

Source: Wikipedia, the free encyclopedia.

cognitive ability.[1] Several factors can lead to significant cognitive impairment, particularly if they occur during pregnancy and childhood when the brain is growing and the blood–brain barrier
of the child is less effective. Such impairment may sometimes be permanent, sometimes be partially or wholly compensated for by later growth.

Developed nations have implemented several health policies regarding nutrients and toxins known to influence cognitive function. These include laws requiring

organochlorides). Comprehensive policy recommendations targeting reduction of cognitive impairment in children have been proposed.[2][3]

Improvements in nutrition (often involving specific micronutrients) due to public policy changes have been implicated in IQ increases in many nations (as part of the overall Flynn effect), such as efforts fighting iodine deficiency in the U.S.[4]

Nutrition

Malnutrition may occur during several periods of growth, such as

micronutrients, protein
or energy. This may cause different effects.

Timing

Some observers have argued that malnutrition during the first six months of life harms cognitive development much more than malnutrition later in life. However, a study from the Philippines argues that malnutrition in the second year of life may have a larger negative impact than malnutrition in the first year of life. While it is debatable whether or not as an infant or after two years is the worst time for malnourishment, the bottom line in these studies is that not having enough nutrients at a young age negatively effects learning. [5]

Intrauterine growth retardation

Undernutrition during pregnancy, and other factors, may cause

Dutch famine of 1944 caused a decrease in mean birthweight in certain areas. This was later associated with a change in performance on IQ tests for 18–19 years old Dutch males draftees from these areas compared to control areas. The subjects were exposed to famine prenatally but not after birth. During the famine, births decreased more among those with lower socioeconomic status (SES), whereas after the famine, there was a compensatory increase in births among those with lower SES. Since SES correlates with IQ, this may have hidden an effect caused by the undernutrition.[6]

Breastfeeding

Studies often find higher IQ in children and adults who were breastfed.[3][7] It has been proposed that omega-3 fatty acids in breast milk, known to be essential constituents of brain tissues, could at least partially account for an increase in IQ.

Recently, however, the longstanding belief that

British Medical Journal. The results indicated that mother's IQ, not breastfeeding, explained the differences in the IQ scores of offspring measured between ages 5 and 14. The results of this meta-analysis argued that prior studies had not controlled for the mother's IQ. Since mother's IQ was predictive of whether a child was breastfed, the study concluded that "breast feeding [itself] has little or no effect on intelligence in children." Instead, it was the mother's IQ that had a significant correlation with the IQ of her offspring, whether the offspring was breastfed or was not breastfed.[8]

One study found that breastfeeding was linked to raised IQ (as much as 7 points when not controlling for maternal IQ) if the infants had an SNP coding for a "C" rather than G base within the FADS2 gene. Those with the "G" version showed no IQ advantage, suggesting a biochemical interaction of child's genes on the effect of breastfeeding.[9][10] Other studies have failed to replicate any correlation between the FADS2 gene,[11] breastfeeding and IQ, while others show a negative effect on IQ when combining bottled feeding, and the "G" version of FADS2.[12]

Infancy

Two studies in Chile on 18-year-old high-school graduates found that nutritional status during the first year of life affected IQ, scholastic achievement, and brain volume.[13][14]

Micronutrients and vitamin deficiencies

iron) influence the development of intelligence and remain a problem in the developing world. For example, iodine deficiency causes a fall, on average, of 12 IQ points. These deficiencies could technically show up in medical scans at various ages. [15]

Policy recommendations to increase availability of micronutrient supplements have been made and justified in part by the potential to counteract intelligence-related developmental problems. For example, the

anaemia because of insufficient iron in their diets.[16]

A joint statement on vitamin and mineral deficiencies says that the severity of such deficiencies "means the impairment of hundreds of millions of growing minds and the lowering of national IQs." Since the brain is not fully developed until age 25, this can be effecting people through their late teens.[17]

Overall, studies investigating whether cognitive function in already iron-deficient children can be improved with iron supplements have produced mixed results, possibly because deficiency in critical growth periods may cause irreversible damage. However, several studies with better design have shown substantial benefits. One way to prevent iron deficiency is to give specific supplementation to children, for example as tablets. However, this is costly, distribution mechanisms are often ineffective, and

compliance is low. Fortification of staple foods (cereals, flour, sugar, salt) to deliver micronutrients to children on a large scale is probably the most sustainable and affordable option, even though commitment from governments and the food industry is needed.[18] Developed nations fortify several foods with various micronutrients.[19]

Additional vitamin-mineral supplementation may have an effect also in the developed world. A study giving such supplementation to "working class", primarily Hispanic, 6–12-year-old children in the United States for 3 months found an average increase of 2 to 3 IQ points. Most of this can be explained by the very large increase of a subgroup of the children, presumably because these were not adequately nourished unlike the majority. The study suggests that parents of schoolchildren whose academic performance is substandard would be well advised to seek a nutritionally oriented physician for assessment of their children's nutritional status as a possible etiology.[20]

More speculatively, other nutrients may prove important in the future.

pregnant and lactating mothers has been linked to increased cognitive ability in one study.[22]

Another study found that pregnant women who consumed 340 grams of low-mercury containing

mental retardation.[23][24][25][26][27][28]

Protein and energy malnutrition

One study from a developing country, Guatemala, found that poor growth during infancy, rather than low birth weight, was negatively related to adolescent performance on cognitive and achievement tests.[29] A later related very long-term study looked at the effect of giving 6–24-month-old children in Guatemala a high protein-energy drink as a dietary supplement. A significantly positive and fairly substantial effects was found on increasing the probability of attending school and of passing the first grade, increasing the grade attained by age 13, increasing completed schooling attainment, and for adults aged 25–40 increasing IQ test scores.[30]

Stunting

31% of children under the age of 5 in the developing world are moderately (height-for-age is below minus 2 standard deviations) or severely stunted (below minus 3 standard deviations).[31] The prevalence was even higher previously since the worldwide prevalence of stunting is declining by about half of a percentage point each year.[32] A study on stunted children aged 9–24 months in Jamaica found that when aged 17–18 years they had significantly poorer scores than a non-stunted group on cognitive and educational tests and psychosocial functioning. Giving a nutritional supplementation (1 kg milk based formula each week) to these already stunted children had no significant effect on later scores, but psychosocial stimulation (weekly play sessions with mother and child) had a positive effect.[33][34]

Toxins

Industrial chemicals

Certain toxins, such as

petrol. Although these prevention campaigns are highly successful, most were initiated only after substantial delays.[35]

Policies to manage lead differ between nations, particularly between the developed and developing world. Use of leaded gasoline has been reduced or eliminated in most developed nations, and lead levels in US children have been substantially reduced by policies relating to lead reduction.[36] Even slightly elevated lead levels around the age of 24 months are associated with intellectual and academic performance deficits at age 10 years.[37]

Certain, at least previously, widely used

DDT, and PCB, have been associated with cognitive deficits.[38]

A Lancet review identified 201 chemicals with the ability to cause clinical neurotoxic effects in human adults, as described in the peer-reviewed scientific literature. Most of them are commonly used. Many additional chemicals have been shown to be neurotoxic in laboratory models. The article notes that children are more vulnerable and argues that new, precautionary approaches that recognise the unique vulnerability of the developing brain are needed for testing and control of chemicals in order to avoid the previous substantial before starting restrictions on usage.[39] An appendix listed further industrial chemicals considered to be neurotoxic.[40]

Alcohol and drugs

Fetal alcohol syndrome, is one of the leading known causes of intellectual disability in the Western world.[41]

Current cannabis use was found to be significantly correlated in a dose-dependent manner with a decline in IQ scores, during the effect of the use. However, no such decline was seen in subjects who had formerly been heavy cannabis users and had stopped taking the drug. The authors concluded that cannabis does not have a long-term effect on intelligence. However this is contradicted by the long-term longitudinal study, carried out by Otago and Duke universities, which found that regular use of marijuana in teenage years affects IQ in adulthood even when the use stops. The drop in IQ was 8 points. Adults smoking marijuana had no lasting effect on IQ.[42] Effects on fetal development are minimal when compared with the well-documented adverse effects of tobacco or alcohol use.[43]

Maternal

race, region, poverty, parent education and marital status, ferritin, and blood lead concentration.[46]

Healthcare during pregnancy and childbirth

Healthcare during pregnancy and childbirth, access to which is often governed by policy, also influences cognitive development. Preventable causes of low intelligence in children include infectious diseases such as meningitis, parasites, and cerebral malaria, prenatal drug and alcohol exposure, newborn asphyxia, low birth weight, head injuries, and endocrine disorders. A direct policy focus on determinants of childhood cognitive ability has been urged.[2]

Stress

Further information: Psychological trauma, Historical trauma, and Neuroplasticity

A recent theory suggests that early childhood stress may affect the developing brain and cause negative effects.[47] Exposure to violence in childhood has been associated with lower school grades[48] and lower IQ in children of all races.[49] A group of largely African American urban first-grade children and their caregivers were evaluated using self-report, interview, and standardized tests, including IQ tests. The study reported that exposure to violence and trauma-related distress in young children were associated with substantial decrements in IQ and reading achievement. Exposure to violence or trauma was correlated with a 7.5-point (SD, 0.5) decrement in IQ and a 9.8-point (SD, 0.66) decrement in reading achievement.[48]

Violence may have a negative impact on IQ, or IQ may be protective against violence.[49] The causal mechanism and direction of causation is unknown.[48] Neighborhood risk has been related to lower school grades for African-American adolescents in another study from 2006.[50]

Infectious diseases

A 2010 study by Eppig, Fincher and Thornhill found a close correlation between the infectious disease burden in a country and the average IQ of its population. The researchers found that when disease was controlled for, IQ showed no correlation with other variables such as educational and nutritional levels. Since brain development requires a very high proportion of all the body's energy in newborns and children, the researchers argue that fighting infection reduces children's IQ potential. The Eppig research may help to explain the Flynn effect, the rise in intelligence noted in rich countries.[51] They also tested other hypotheses as well, including genetic explanations, concluding that infectious disease was "the best predictor".[52] Christopher Hassall and Thomas Sherratt repeated the analysis, and concluded "that infectious disease may be the only really important predictor of average national IQ".[52]

In order to mitigate the effects of education on IQ, Eppig Fincher & Thornhill repeated their analysis across the United States where standardized and compulsory education exists.[52][53] The correlation between infectious disease and average IQ was confirmed, and they concluded that the "evidence suggests that infectious disease is a primary cause of the global variation in human intelligence".[52]

Tropical infectious diseases

Malaria affects 300–500 million persons each year, mostly children under age five in Africa, causing widespread anemia during a period of rapid brain development and also direct brain damage from cerebral malaria to which children are more vulnerable.[54] A 2006 systematic review found that Plasmodium falciparum infection causes cognitive deficits in both the short- and long-term.[55] Policies aimed at malaria reduction may have cognitive benefits. It has been suggested that the future economic and educational development of Africa critically depends on the eradication of malaria.

Roundworms infect hundreds of millions of people. There is evidence that high intensities of worms in the intestines can affect mental performance,[56] but a systematic review in 2000 and a 2009 update found that there was insufficient evidence to show that deworming treatments improve cognitive performance or school performance in children.[57][58]

HIV infection in children in sub-Saharan Africa affects their motor development, but there is insufficient evidence to show a slowing of language development.[59]

Effects of other diseases

There are numerous diseases affecting the

psychiatric and may primarily affect the brain. Others may affect many other organs, like HIV, Hashimoto's thyroiditis causing hypothyroidism, or cancer. According to a 2015 report in The American Scholar, an assortment of neglected tropical diseases as well as some recently identified pathogens such as Pseudo-nitzschia have also been found to erode human intelligence.[60]

Major depression, affecting about 16% of the population on at least one occasion in their lives and the leading cause of disability in North America, may give symptoms similar to dementia. Patients treated for depression score higher on IQ tests than before treatment.[61][62]

Myopia and hyperopia

A 2008 literature review writes that studies in several nations have found a relationship between

pleiotropic gene(s) affect the size of both brain and eyes simultaneously.[63] A study of Chinese schoolchildren found that after controlling for age, gender, school, parental myopia, father's education, and books read per week, myopia was still associated with high nonverbal IQ. Nonverbal IQ was a more important explanation than books read per week.[64]

Other associations

Long working hours (55 vs. 40) was associated with decreased scores on cognitive tests in a 5-year study on midlife British civil servants.[65]

See also

  • Cognitive epidemiology – Field of research
  • Flynn effect – 20th-century rise in intelligence test scores
  • g factor (psychometrics) – Psychometric factor also known as "general intelligence"
  • Health and race
     – Health based on racial identity
  • Race and height
     – Aspect of human growth

References

  1. S2CID 205042144
    .
  2. ^
    S2CID 31999992
    .
  3. ^
    ISBN 978-0-7679-2301-9
    .
  4. ^ Nisen, Max (July 22, 2013). "How Adding Iodine To Salt Resulted In A Decade's Worth Of IQ Gains For The United States". Business Insider. Retrieved June 25, 2016.
  5. hdl:10986/17213
    .
  6. PMID 9547065. Archived from the original on January 29, 2007. Neisser; et al. (August 7, 1995). "Intelligence: Knowns and Unknowns". Board of Scientific Affairs of the American Psychological Association. Archived from the original
    on June 1, 2012. Retrieved August 6, 2006.
  7. ISBN 0-275-95655-5
    .
  8. PMID 17020911
    .
  9. ^ "Baby's IQ Raised by Breastmilk and Genes". Archived from the original on 2010-07-26. Retrieved 2007-11-20.
  10. PMID 17984066
    .
  11. PMID 21156270
    .
  12. PMID 20644632
    .
  13. PMID 11895316
    .
  14. S2CID 2114185
    .
  15. PMID 15734706
    .
  16. ^ Behrman, J.R., Alderman, H., and Hoddinott, J., "Hunger and Malnutrition Archived 2012-07-17 at the Wayback Machine," Copenhagen Consensus 2004.
  17. Micronutrient Initiative, "Vitamin & Mineral Deficiency: A Global Progress Report Archived 2008-09-24 at the Wayback Machine
    ," March 2004.
  18. PMID 11744547
    .
  19. ^ FOOD FORTIFICATION TECHNOLOGY Food Fortification: Technology and Quality Control. (FAO Food And Nutrition Paper - 60)
  20. PMID 10706232
    .
  21. PMID 11976166
    . Erratum in: Am. J. Clin. Nutr. 77 (2): 523.
  22. PMID 12509593
    .
  23. S2CID 35728830
    .
  24. ^ Pregnant Women: Eat More Fish or Not? - To Your Health - MSNBC.com
  25. ^ Fish Diet in Pregnancy May Hone Kids' IQ
  26. ^ "The omega point". The Economist. January 19, 2006.
  27. ^ Medical News: Eating Fish During Pregnancy Provides 'Brain Food' for Child - in OB/GYN, Pregnancy from MedPage Today
  28. ^ Pregnant? Omega-3 Essential for Baby's Brain
  29. PMID 8272081
    .
  30. PMID 16060211
    .
  31. ^ "Children's Health: Stunting in children under 5-moderate and severe". World Resources Institute. Archived from the original on February 5, 2012.
  32. ^ Susan S. Lang (May 29, 1998). "Stunted growth affects almost 40 percent of the developing world's infants, Cornell study reports". Cornell News. Archived from the original on June 17, 2012.
  33. S2CID 25797832
    .
  34. PMID 16877454
    .
  35. S2CID 12795774
    .
  36. PMID 12971691
    .
  37. S2CID 25746146
    .
  38. PMID 16968864
    .
  39. S2CID 12795774
    .
  40. Harvard School of Public Health, Boston
    , MA, USA
  41. PMID 3545731
    .
  42. ^ Nature Journal. August 2012 and 30mt Radio discussion on Radio NZ with authors
  43. PMID 15661628
    .
  44. PMID 12009494
    .
  45. PMID 16085682
    .
  46. PMID 15626655. Archived from the original
    on 2012-07-12. Retrieved 2009-06-14.
  47. S2CID 8508500. Multiple comments can be seen on Google Scholar.
  48. ^
    PMID 11876674
    .
  49. ^
    S2CID 14002367
    .
  50. S2CID 37387862
    .
  51. ^ MacKenzie, Debora. "Link found between infectious disease and IQ". New Scientist. Retrieved 4 July 2010.
  52. ^ a b c d Eppig, Christopher (2011). "Why Is Average IQ Higher in Some Places?". Scientific American.
  53. PMID 20591860
    .
  54. S2CID 26453764
    .
  55. PMID 16553922
    .
  56. PMID 9100486
    .
  57. PMID 10864543
    .
  58. PMID 19172183
    .
  59. PMID 18384479
    .
  60. ^ Washington, Harriet A. (2015). "The Well Curve". The American Scholar (Autumn): 12.
  61. PMID 1572949.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  62. S2CID 32869139
    .
  63. PMID 19127804
    .
  64. PMID 15326105
    .
  65. PMID 19126590
    .
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