Inflammatory reflex

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The inflammatory reflex is a neural circuit that regulates the immune response to injury and invasion. All reflexes have an

It has also been shown that the brain can use this circuit not only to regulate the immune response but also to extend the immunological memory^[1][2]

Molecular mechanism

The molecular basis of cytokine-inhibiting signals requires the neurotransmitter acetylcholine, and the Alpha-7 nicotinic receptor receptor expressed on cytokine-producing cells.^[3][4] The release of acetylcholine in spleen suppresses the production of TNF and other cytokines which causes damaging inflammation.^[5] Signaling in the efferent arc of the inflammatory reflex, termed the "Cholinergic anti-inflammatory pathway," provides a regulatory check on the innate immune system response to invasion and injury. The action potentials that arise in the vagus nerve are transmitted to the spleen, where a subset of specialized T cells are activated to secrete acetylcholine. The net effect of the reflex is to prevent the damage caused by excessive cytokine production.^[6]

Therapeutic potential

Evidence from experimental disease models of

• Interoception
• Pavlovian conditioning

References