Initial volume of distribution

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The initial volume of distribution (V_i) is a

Therefore the dose required to give a certain plasma concentration can be determined if the V_D for that drug is known. The V_D is not a real volume; it is more a reflection of how a drug will distribute throughout the body depending on several physicochemical properties, e.g. solubility, charge, size, etc. The V_D may also be used to determine how readily a drug will displace into the body tissue compartments relative to the blood:

${\displaystyle {V_{D}}={V_{P}}+{V_{T}}\left({\frac {fu}{fu_{t}}}\right)}$

Where:

V_P = plasma volume

V_T = apparent tissue volume

fu = fraction unbound in plasma

fu_T = fraction unbound in tissue

References